Inhibition of hexose transport by glucose in a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
2691359
DOI
10.1007/bf02814468
Knihovny.cz E-zdroje
- MeSH
- aktivní transport účinky léků MeSH
- glukosa-6-fosfátisomerasa genetika metabolismus MeSH
- glukosa farmakologie MeSH
- hexosy farmakokinetika MeSH
- kinetika MeSH
- mutace MeSH
- Saccharomyces cerevisiae genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glukosa-6-fosfátisomerasa MeSH
- glukosa MeSH
- hexosy MeSH
The rate of hexose transport was approximately 60% lower for both the high- and the low-affinity components of hexose uptake when a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae was preincubated with glucose, as compared with preincubation with water. Similarly the Jmax value of the high-affinity system of the mutant was 25-35% of the corresponding Jmax value for normal cells incubated with glucose. Accumulation of glucose 6-phosphate or of some other metabolite, such as fructose 6-phosphate or trehalose, may be responsible for this striking inhibition.
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