Inhibition of hexose transport by glucose in a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae
Language English Country United States Media print
Document type Journal Article
PubMed
2691359
DOI
10.1007/bf02814468
Knihovny.cz E-resources
- MeSH
- Biological Transport, Active drug effects MeSH
- Glucose-6-Phosphate Isomerase genetics metabolism MeSH
- Glucose pharmacology MeSH
- Hexoses pharmacokinetics MeSH
- Kinetics MeSH
- Mutation MeSH
- Saccharomyces cerevisiae genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glucose-6-Phosphate Isomerase MeSH
- Glucose MeSH
- Hexoses MeSH
The rate of hexose transport was approximately 60% lower for both the high- and the low-affinity components of hexose uptake when a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae was preincubated with glucose, as compared with preincubation with water. Similarly the Jmax value of the high-affinity system of the mutant was 25-35% of the corresponding Jmax value for normal cells incubated with glucose. Accumulation of glucose 6-phosphate or of some other metabolite, such as fructose 6-phosphate or trehalose, may be responsible for this striking inhibition.
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