Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24439412
DOI
10.1016/j.biomaterials.2013.12.098
PII: S0142-9612(13)01594-9
Knihovny.cz E-zdroje
- Klíčová slova
- Apoptosis, Cell proliferation, Leukemia, Magnetic field, Modeling, Reactive oxygen species,
- MeSH
- apoptóza MeSH
- leukemie metabolismus patologie MeSH
- lidé MeSH
- magnetismus * MeSH
- mechanický stres MeSH
- monocyty metabolismus patologie MeSH
- nádorové buněčné linie MeSH
- reaktivní formy kyslíku metabolismus MeSH
- teoretické modely * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- reaktivní formy kyslíku MeSH
The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructive physical approach.
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