Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24439412
DOI
10.1016/j.biomaterials.2013.12.098
PII: S0142-9612(13)01594-9
Knihovny.cz E-resources
- Keywords
- Apoptosis, Cell proliferation, Leukemia, Magnetic field, Modeling, Reactive oxygen species,
- MeSH
- Apoptosis MeSH
- Leukemia metabolism pathology MeSH
- Humans MeSH
- Magnetics * MeSH
- Stress, Mechanical MeSH
- Monocytes metabolism pathology MeSH
- Cell Line, Tumor MeSH
- Reactive Oxygen Species metabolism MeSH
- Models, Theoretical * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Reactive Oxygen Species MeSH
The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructive physical approach.
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