Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
32017935
DOI
10.1016/j.ejphar.2020.172973
PII: S0014-2999(20)30065-0
Knihovny.cz E-zdroje
- Klíčová slova
- Antioxidants, Curcumin, EGCG, Flavonoids, Melatonin, Neuroinflammation, Nrf2 inducers, Oxidative stress, Resveratrol,
- MeSH
- faktor 2 související s NF-E2 účinky léků MeSH
- KEAP-1 účinky léků MeSH
- lidé MeSH
- roztroušená skleróza farmakoterapie MeSH
- signální transdukce účinky léků MeSH
- vezikulární transportní proteiny účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- faktor 2 související s NF-E2 MeSH
- KEAP-1 MeSH
- KEAP1 protein, human MeSH Prohlížeč
- NFE2L2 protein, human MeSH Prohlížeč
- vezikulární transportní proteiny MeSH
- VPS52 protein, human MeSH Prohlížeč
Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic inflammation of the central nervous system, demyelination and axonal damage. Recently, the term "oxinflammation" has been proposed to depict the vicious circle of chronic inflammation and oxidative stress (OS). OS promotes demyelination and neurodegeneration directly, by oxidation of lipids, proteins, and DNA but also indirectly, by inducing a dysregulation of the immunity and favoring the state of pro-inflammatory response. Many of the actors of this delicately tuned network are controlled by Keap1/Nrf2/ARE signaling pathway, a principal regulator of antioxidant and phase II detoxification genes. This pathway also has a pivotal role in inflammation, and therefore possesses a great potential in the treatment of MS. The aim of this review is to provide the newest insights in the preclinical and clinical evidence of Nrf2 induction in the regeneration of the antioxidant response and attenuation of inflammation in MS. Preclinical studies have indicated that activators of this pathway, such as epigallocatechin gallate (EGCG), curcumin, melatonin, resveratrol, and sulforaphane might be a promising therapeutic option in amelioration of MS symptoms, nevertheless, the efficacy and safety of these compounds have to be confirmed in future clinical trials.
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