PURPOSE OF REVIEW: Cancer diagnosis in young pregnant women challenges oncological decision-making. The International Network on Cancer, Infertility and Pregnancy (INCIP) aims to build on clinical recommendations based on worldwide collaborative research. RECENT FINDINGS: A pregnancy may complicate diagnostic and therapeutic oncological options, as the unborn child must be protected from potentially hazardous exposures. Pregnant patients should as much as possible be treated as non-pregnant patients, in order to preserve maternal prognosis. Some approaches need adaptations when compared with standard treatment for fetal reasons. Depending on the gestational age, surgery, radiotherapy, and chemotherapy are possible during pregnancy. A multidisciplinary approach is the best guarantee for experience-driven decisions. A setting with a high-risk obstetrical unit is strongly advised to safeguard fetal growth and health. Research wise, the INCIP invests in clinical follow-up of children, as cardiac function, neurodevelopment, cancer occurrence, and fertility theoretically may be affected. Furthermore, parental psychological coping strategies, (epi)genetic alterations, and pathophysiological placental changes secondary to cancer (treatment) are topics of ongoing research. Further international research is needed to provide patients diagnosed with cancer during pregnancy with the best individualized management plan to optimize obstetrical and oncological care.

Centre for Gynecological Oncology Amsterdam Amsterdam University Medical Centers Amsterdam The Netherlands

Centre for Gynecological Oncology Amsterdam Antoni van Leeuwenhoek Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam The Netherlands

Department of Development and Regeneration KU Leuven Leuven Belgium

Department of Gynecology Antoni van Leeuwenhoek Netherlands Cancer Institute Amsterdam The Netherlands

Department of Obstetrics and Gynecology Amsterdam University Medical Centers Vrije Universiteit Amsterdam Amsterdam The Netherlands

Department of Obstetrics and Gynecology Cooper University Health Care Camden NJ USA

Department of Obstetrics University Hospitals Leuven Leuven Belgium

Department of Oncology KU Leuven Leuven Belgium

Faculty Hospital Kralovske Vinohrady and 3rd Medical Faculty Charles University Prague Czech Republic

Neonatal Intensive Care Unit Department of Clinical Sciences and Community Health Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano Milan Italy

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