Ascaridole-rich essential oil from marsh rosemary (Ledum palustre) growing in Poland exerts insecticidal activity on mosquitoes, moths and flies without serious effects on non-target organisms and human cells
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
32061727
DOI
10.1016/j.fct.2020.111184
PII: S0278-6915(20)30072-7
Knihovny.cz E-resources
- Keywords
- Adulticide, Botanical pesticide, Culex quinquefasciatus, Housefly, Larvicide, Spodoptera littoralis,
- MeSH
- Cell Line MeSH
- Culex drug effects MeSH
- Culicidae drug effects MeSH
- Cymenes analysis pharmacology MeSH
- Daphnia drug effects MeSH
- Insecticides analysis pharmacology MeSH
- Keratinocytes cytology drug effects MeSH
- Mosquito Vectors drug effects MeSH
- Comet Assay MeSH
- Larva drug effects MeSH
- Humans MeSH
- Cyclohexane Monoterpenes analysis pharmacology MeSH
- Houseflies drug effects MeSH
- Moths drug effects MeSH
- Oils, Volatile analysis pharmacology MeSH
- Oligochaeta drug effects MeSH
- Peroxides analysis pharmacology MeSH
- Pyrethrins analysis pharmacology MeSH
- Insect Repellents analysis pharmacology MeSH
- Rosmarinus chemistry MeSH
- Spodoptera drug effects MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Poland MeSH
- Names of Substances
- 4-cymene MeSH Browser
- ascaridole MeSH Browser
- Cymenes MeSH
- cypermethrin MeSH Browser
- Insecticides MeSH
- Cyclohexane Monoterpenes MeSH
- Oils, Volatile MeSH
- Peroxides MeSH
- Pyrethrins MeSH
- Insect Repellents MeSH
Marsh rosemary (Ledum palustre, Ericaceae) has been widely used in the traditional medicine of various regions worldwide, and as insect repellent. Little is known on its essential oil insecticidal potential. This study explored the insecticidal effects of the essential oil obtained from L. palustre growing in Poland on selected insect pests and vectors. GC-MS analysis evidenced an uncommon chemotype characterized by ascaridole (35.3% as sum of cis-ascaridole and isoascaridole) and p-cymene (25.5%). The essential oil was effective against Culex quinquefasciatus, Spodoptera littoralis and Musca domestica, showing LC50/LD50 of 66.6 mg L-1, 117.2 μg larva-1 and 61.4 μg adult-1, respectively. It was not toxic to non-target Eisenia fetida earthworms and moderately toxic to Daphnia magna microcrustaceans, over the positive control α-cypermethrin. The essential oil cytotoxicity on human keratinocytes and fibroblasts showed high IC50 values (71.3 and 84.4 μg mL-1, respectively). Comet assay data highlighted no DNA damages. Based on our findings, this essential oil, characterized by the ascaridole/p-cymene chemotype, could be a candidate for the formulation of botanical insecticides; large-scale production of green insecticides by this rare species may be assured by ex situ cultivation and biotechnological techniques.
Crop Research Institute Drnovska 507 161 06 Prague Czech Republic
School of Pharmacy University of Camerino via Sant'Agostino 1 62032 Camerino Italy
School of Sciences and Technology University of Camerino via Sant'Agostino 1 62032 Camerino Italy
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