Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32277573
DOI
10.1002/mnfr.201901238
Knihovny.cz E-zdroje
- Klíčová slova
- calanus, fatty acids, krill, mast cells, stereoisomers,
- MeSH
- antiflogistika nesteroidní krev farmakokinetika MeSH
- biologická dostupnost MeSH
- chemotaxe účinky léků MeSH
- kyseliny dokosahexaenové farmakokinetika MeSH
- kyseliny linolové chemie MeSH
- kyseliny mastné omega-3 farmakokinetika farmakologie MeSH
- mastocyty účinky léků MeSH
- myši inbrední C57BL MeSH
- oleje chemie farmakokinetika MeSH
- stereoizomerie MeSH
- triglyceridy chemie MeSH
- vodní organismy MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 13-hydroxylinoleic acid MeSH Prohlížeč
- antiflogistika nesteroidní MeSH
- kyseliny dokosahexaenové MeSH
- kyseliny linolové MeSH
- kyseliny mastné omega-3 MeSH
- oleje MeSH
- triglyceridy MeSH
SCOPE: The docosahexaenoic acid ester of hydroxy linoleic acid (13-DHAHLA) is a bioactive lipid with anti-inflammatory properties from the family of fatty acid esters of hydroxy fatty acids (FAHFA). METHODS AND RESULTS: To explore the biosynthesis of 13-DHAHLA from dietary oils, C57BL/6N mice are gavaged for 8 days with various corn oil/marine oil mixtures containing the same amount of DHA. Plasma levels of omega-3 FAHFAs are influenced by the lipid composition of the mixtures but do not reflect the changes in bioavailability of polyunsaturated fatty acids in plasma. Triacylglycerol-bound DHA and linoleic acid serve as more effective precursors for 13-DHAHLA synthesis than DHA bound in phospholipids or wax esters. Both 13(S)- and 13(R)-DHAHLA inhibit antigen and PGE2 -induced chemotaxis and degranulation of mast cells to a comparable extent and 13(S)-DHAHLA is identified as the predominant isomer in mouse adipose tissue. CONCLUSION: Here, the optimal nutritional source of DHA is identified, which supports production of anti-inflammatory FAHFAs, as triacylglycerol-based marine oil and also reveals a possible role of triacylglycerols in the synthesis of FAHFA lipokines.
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Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids
