Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- chinony chemie metabolismus farmakologie MeSH
- HeLa buňky MeSH
- lidé MeSH
- ligandy MeSH
- myši nahé MeSH
- myši MeSH
- oxidace-redukce účinky léků MeSH
- protinádorové látky chemie metabolismus farmakologie MeSH
- ruthenium chemie metabolismus farmakologie MeSH
- viabilita buněk účinky léků fyziologie MeSH
- xenogenní modely - testy protinádorové aktivity metody MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chinony MeSH
- ligandy MeSH
- protinádorové látky MeSH
- ruthenium MeSH
Chemotherapy remains one of the dominant treatments to cure cancer. However, due to the many inherent drawbacks, there is a search for new chemotherapeutic drugs. Many classes of compounds have been investigated over the years to discover new targets and synergistic mechanisms of action including multicellular targets. In this work, we designed a new chemotherapeutic drug candidate against cancer, namely, [Ru(DIP)2(sq)](PF6) (Ru-sq) (DIP = 4,7-diphenyl-1,10-phenanthroline; sq = semiquinonate ligand). The aim was to combine the great potential expressed by Ru(II) polypyridyl complexes and the singular redox and biological properties associated with the catecholate moiety. Experimental evidence (e.g., X-ray crystallography, electron paramagnetic resonance, electrochemistry) demonstrates that the semiquinonate is the preferred oxidation state of the dioxo ligand in this complex. The biological activity of Ru-sq was then scrutinized in vitro and in vivo, and the results highlight the promising potential of this complex as a chemotherapeutic agent against cancer.
Department of Chemistry University of Konstanz Universitätsstrasse 10 D 78457 Konstanz Germany
Department of Chemistry University of Zurich Winterthurerstrasse 190 8057 Zurich Switzerland
Institut Curie PSL University CNRS UMR 144 F 75005 Paris France
Institute of Molecular Cancer Research University of Zurich CH 8057 Zurich Switzerland
Université de Paris Institut de physique du Globe de Paris CNRS F 75005 Paris France
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