Thrombotic microangiopathy and pregnancy
Jazyk angličtina Země Česko Médium print
Typ dokumentu kazuistiky, časopisecké články, přehledy
PubMed
32414281
PII: 122226
Knihovny.cz E-zdroje
- Klíčová slova
- HELLP syndrome, acute fatty liver of pregnancy, atypical hemolytic uremic syndrome, eculizumab, hemolytic uremic syndrome, thrombotic microangiopathy, thrombotic thrombocytopenic purpura,
- MeSH
- kardiovaskulární komplikace v těhotenství diagnóza terapie MeSH
- lidé MeSH
- těhotenství MeSH
- trombotická trombocytopenická purpura MeSH
- trombotické mikroangiopatie diagnóza terapie MeSH
- týmová péče o pacienty MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
OBJECTIVE: The aim of this study is to draw attention to a nosological unit called thrombotic microangiopathy (TMA). This syndrome represents a serious pathological condition characterized by microangiopathic haemolytic anemia (MAHA), thrombocytopenia and various organ dysfunction. Patients are most often presented with symptoms of the HELLP syndrome but if the clinical picture is not restituted within 48-72 hours after delivery, other TMAs should be considered. SETTING: Department of Obstetrics and Gynecology, 1st Medical Faculty and General Teaching Hospital Prague; Clinic of Nephrology, 1st Medical Faculty and General Teaching Hospital Prague; Department of Obstetrics and Gynecology, Regional Hospital Kolín. DESIGN: Review article and case reports. METHODS: Review of the literature and description of two cases of TMA. CONCLUSION: The authors present a basic overview of the issue of TMA, which requires interdisciplinary cooperation of obstetricians, anesthesiologists, nephrologists and hematologists. In the second part of the article, we present two TMA case reports and finally show the differential diagnostic and therapeutic scheme as agreed by the authorities in the field.