PEI-coated PLA nanoparticles to enhance the antimicrobial activity of carvacrol
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
32485586
DOI
10.1016/j.foodchem.2020.127131
PII: S0308-8146(20)30993-6
Knihovny.cz E-resources
- Keywords
- Acetone (PubChem CID: 180), Antimicrobial nanoparticles, Carvacrol, Carvacrol (PubChem CID: 10364), Food preservatives, PEI-coating, PLA, Polyethylenimine (PEI) (CID: 86276476), Polylactide (PubChem CID: 11039), Polyvinyl alcohol (PubChem CID: 11199), Tetrahydrofuran (PubChem CID: 7272), rac-lactide (PubChem CID: 7272),
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Cymenes chemistry pharmacokinetics pharmacology MeSH
- Escherichia coli drug effects MeSH
- Listeria monocytogenes MeSH
- Microbial Sensitivity Tests MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers chemistry MeSH
- Polyesters chemistry MeSH
- Polyethyleneimine chemistry MeSH
- Food Microbiology MeSH
- Solubility MeSH
- Salmonella enterica drug effects MeSH
- Staphylococcus aureus drug effects MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- carvacrol MeSH Browser
- Cymenes MeSH
- Drug Carriers MeSH
- poly(lactide) MeSH Browser
- Polyesters MeSH
- Polyethyleneimine MeSH
Carvacrol (CAR) is a natural bioactive compound with antioxidant and antimicrobial activity that is present in essential oils. The application of CAR in food preservation is hampered by its high volatility, low solubility in water, and susceptibility to light, heat and oxygen degradation. Polylactide (PLA) is an FDA-approved polymer derived from renewable resources. Controlled release of CAR from PLA nanoparticles (NPs) could improve its antimicrobial efficacy and storage. In this study, negatively charged CAR-NPs and positively charged polyethylenimine (PEI)-coated CAR-(PEI)NPs were formulated by nanoprecipitation methods and characterised by dynamic light scattering, electron microscopy, encapsulation efficiency, and drug loading capacity. The positively charged (PEI)NPs enhanced the in vitro antimicrobial activity of CAR against Escherichia coli, Listeria monocytogenes, Salmonella enterica and Staphylococcus aureus. Bacterial uptake, evaporation tests, release studies and NP stability after storage were assessed to provide evidence supporting CAR-(PEI)NPs as a potential nanocarrier for further development in food preservation.
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