PEI-coated PLA nanoparticles to enhance the antimicrobial activity of carvacrol
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32485586
DOI
10.1016/j.foodchem.2020.127131
PII: S0308-8146(20)30993-6
Knihovny.cz E-zdroje
- Klíčová slova
- Acetone (PubChem CID: 180), Antimicrobial nanoparticles, Carvacrol, Carvacrol (PubChem CID: 10364), Food preservatives, PEI-coating, PLA, Polyethylenimine (PEI) (CID: 86276476), Polylactide (PubChem CID: 11039), Polyvinyl alcohol (PubChem CID: 11199), Tetrahydrofuran (PubChem CID: 7272), rac-lactide (PubChem CID: 7272),
- MeSH
- antibakteriální látky chemie farmakologie MeSH
- cymeny chemie farmakokinetika farmakologie MeSH
- Escherichia coli účinky léků MeSH
- Listeria monocytogenes MeSH
- mikrobiální testy citlivosti MeSH
- nanočástice chemie MeSH
- nosiče léků chemie MeSH
- polyestery chemie MeSH
- polyethylenimin chemie MeSH
- potravinářská mikrobiologie MeSH
- rozpustnost MeSH
- Salmonella enterica účinky léků MeSH
- Staphylococcus aureus účinky léků MeSH
- velikost částic MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- carvacrol MeSH Prohlížeč
- cymeny MeSH
- nosiče léků MeSH
- poly(lactide) MeSH Prohlížeč
- polyestery MeSH
- polyethylenimin MeSH
Carvacrol (CAR) is a natural bioactive compound with antioxidant and antimicrobial activity that is present in essential oils. The application of CAR in food preservation is hampered by its high volatility, low solubility in water, and susceptibility to light, heat and oxygen degradation. Polylactide (PLA) is an FDA-approved polymer derived from renewable resources. Controlled release of CAR from PLA nanoparticles (NPs) could improve its antimicrobial efficacy and storage. In this study, negatively charged CAR-NPs and positively charged polyethylenimine (PEI)-coated CAR-(PEI)NPs were formulated by nanoprecipitation methods and characterised by dynamic light scattering, electron microscopy, encapsulation efficiency, and drug loading capacity. The positively charged (PEI)NPs enhanced the in vitro antimicrobial activity of CAR against Escherichia coli, Listeria monocytogenes, Salmonella enterica and Staphylococcus aureus. Bacterial uptake, evaporation tests, release studies and NP stability after storage were assessed to provide evidence supporting CAR-(PEI)NPs as a potential nanocarrier for further development in food preservation.
Citace poskytuje Crossref.org
