BACKGROUND: The coronavirus disease 2019 (COVID-19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. METHOD: The scientific information on COVID-19 was analysed by a literature search in MEDLINE, PubMed, the National and International Guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library, and the internet. RESULTS: Based on the diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations, and on previous experience, a panel of experts including clinicians, psychologists, IT experts, and basic scientists along with EAACI and the "Allergic Rhinitis and its Impact on Asthma (ARIA)" initiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. These recommendations are grouped into nine sections on different relevant aspects for the care of patients with allergies. CONCLUSIONS: This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients while ensuring the necessary safety measures in the current COVID-19 pandemic.

Allergy and Clinical Immunology Department of Internal Medicine Santa Maria della Speranza Hospital Salerno Italy

Allergy and Clinical Immunology Unit Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

Allergy and Immunology Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia

Allergy Asthma and Clinical Immunology Alfred Health Melbourne VIC Australia

Allergy Center CUF Descobertas Hospital Lisbon Portugal

Allergy Department 2nd Pediatric Clinic Athens General Children's Hospital P and A Kyriakou University of Athens Athens Greece

Allergy Unit Malaga Regional University Hospital UMA ARADyAL Málaga Spain

Center for Rhinology and Allergology Wiesbaden Germany

Center of Allergy and Immunology Tbilisi Georgia

Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico

Centre for Inflammation Research and Child Life and Heath the University of Edinburgh Edinburgh UK

Chair and Institute of Environmental Medicine UNIKA T Technical University of Munich and Helmholtz Zentrum München Augsburg Germany

Chiba University and Chiba Rosai Hospital Chiba Japan

Children's Allergy Service Evelina Children's Hospital Guy's and St Thomas' Hospital NHS Foundation Trust London UK

David Tvildiani Medical University in Tbilisi Tbilisi Georgia

Department of Allergology Occupational Dermatology and Environmental Medicine University Hospital Münster Münster Germany

Department of Allergy and Immunology Hospital Quironsalud Bizkaia Erandio Spain

Department of Allergy Beijing Tongren Hospital Beijing China

Department of Allergy Immunology and Respiratory Medicine Central Clinical School Monash University and Alfred Health Melbourne VIC Australia

Department of Biochemistry and Molecular Biology Chemistry School Complutense University of Madrid Spain

Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy

Department of Clinical Immunology Wrocław Medical University and ALL MED Medical Research Institute Wrocław Poland

Department of Clinical Pharmacy and Pharmacology University Medical Center Groningen University of Groningen Groningen The Netherlands

Department of Clinical Psychology and Psychotherapy Philipps University of Marburg Marburg Germany

Department of Dermatology and Allergology Helsinki University Hospital Inflammation Centre University of Helsinki Helsinki Finland

Department of Dermatology and Allergy Centre Odense Research Centre for Anaphylaxis Odense University Hospital University of Southern Denmark Odense Denmark

Department of Dermatology and Allergy Comprehensive Allergy Center Charité Charité Universitaetsmedizin Berlin a Member of GA2LEN Berlin Germany

Department of Immunology University of Toronto Toronto ON Canada

Department of Infection and Immunity Luxembourg Institute of Health Esch sur Alzette Luxembourg

Department of Information Technology University Hospital Marburg Marburg Germany

Department of Internal Medicine Allergology Clinical Immunology Medical University of Silesia Katowice Poland

Department of Internal Medicine Allergy Section Hospital Vall d'Hebron and ARADyAL Research Network Barcelona Spain

Department of Internal Medicine Division of Immunology and Allergic Diseases Istanbul Faculty of Medicine Istanbul University Istanbul Turkey

Department of Medical Sciences Allergy and Clinical Immunology Unit University of Torino and Mauriziano Hospital Torino Italy

Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy

Department of Occupational Diseases and Environmental Health Nofer Institute of Occupational Medicine Lodz Poland

Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Beijing China

Department of Otolaryngology National University of Singapore Singapore Singapore

Department of Otorhinolaryngology Amsterdam University Medical Centres Amsterdam The Netherlands

Department of Otorhinolaryngology Cliniques Universitaires Saint Luc Brussels Belgium

Department of Otorhinolaryngology Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps Universität Marburg Marburg Germany

Department of Pathology Faculty of Medicine Institute of Biomedical Sciences Vilnius University Vilnius Lithuania

Department of Pediatric Pulmonology Immunology and Intensive Care Medicine Charité Universitaetsmedizin Berlin Germany

Department of Prevention of Environmental Hazards and Allergology Medical University of Warsaw Warsaw Poland

Department of Pulmonary Diseases Faculty of Medicine Celal Bayar University Manisa Turkey

Department of Respiratory Medicine 1st Faculty of Medicine Charles University and Thomayer Hospital Prague Czech Republic

Department of Respiratory Medicine and Allergology Institute for Clinical Science Skane University Hospital Lund University Lund Sweden

Department of Respiratory Medicine Hvidovre Hospital Hvidovre Denmark

Departments of Immunology and Dermatology Allergology University Medical Center Utrecht Utrecht The Netherlands

Departments of Medicine and Microbiology APC Microbiome Ireland University College Cork Cork Ireland

Departments of Paediatrics and Immunology Division of Immunology and Allergy Food Allergy and Anaphylaxis Program The Hospital for Sick Children University of Toronto Toronto ON Canada

Division of ENT Diseases CLINTEC Karolinska Institutet Stockholm Sweden

Division of Infection Immunity and Respiratory Medicine Royal Manchester Children's Hospital University of Manchester Manchester UK

Division of Internal Medicine Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland

ENT Department Rhinology Unit and Smell Clinic Hospital Clinic Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES University of Barcelona Barcelona Catalonia Spain

ENT Department Upper Airways Research Laboratory Ghent University Hospital Ghent Belgium

Faculdade de Medicina da Universidade do Porto CINTESIS Center for Research in Health Technologies and Information Systems Porto Portugal

Faculty of Health Sciences Institute of Clinical Medicine University of Copenhagen Denmark

Faculty of Medicine Institute of Clinical Medicine and Institute of Health Sciences Vilnius University Vilnius Lithuania

Faculty of Medicine Institute of Clinical medicine Clinic of Chest Diseases and Allergology Vilnius University Vilnius Lithuania

GARD WHO Executive Committee Bahia Brazil

ICBR Coimbra Institute for Clinical and Biomedical Research CIBB Faculty of Medicine University of Coimbra Coimbra Portugal

Institut de Recerca Sant Joan de Déu Barcelona Spain

Institute of Immunology Faculty of Medicine University of Coimbra Coimbra Portugal

Institute of Medical Psychology and Behavioral Immunobiology University Clinic Essen Essen Germany

Institute of Pathophysiology and Allergy Research Center of Pathophysiology Infectiology and Immunology Medical University of Vienna Vienna Austria

Interdisciplinary Department of Medicine Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy

International Airway Research Center 1st Affiliated Hospital Guangzou Sun Yat sen University Guangzou China

Japan Anti Tuberculosis Association Tokyo National Hospital Tokyo Japan

Johns Hopkins School of Medicine Baltimore MD USA

MACVIA France Montpellier France

Medical Consulting Czarlewski Levallois Perret France

MEDIDA Lda Porto Portugal

National Heart and Lung Institute Imperial College London London UK

NOVA Medical School Comprehensive Health Research Center Universidade Nova de Lisboa Lisbon Portugal

Outpatient Clinic for Environmental Medicine University Hospital Augsburg Germany

Paediatric Allergy Group Department of Women and Children's Health School of Life Course Sciences King's College London London UK

Pediatric Allergy and Clinical Immunology Department Hospital Sant Joan de Déu Barcelona Spain

Personalized Medicine Asthma and Allergy Clinic Humanitas University and Research Hospital IRCCS Milano Italy

ProAR Nucleo de Excelencia em Asma Federal University of Bahia Bahia Brasil

Royal Brompton and Harefield NHS Foundation Trust London UK

School of Medicine University CEU San Pablo Madrid Spain

Sean N Parker Center for Allergy and Asthma Research Stanford University School of Medicine Stanford CA USA

Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina

Serviço de Imunoalergologia Hospital de Dona Estefânia Centro Hospitalar de Lisboa Central Lisbon Portugal

Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland

Swiss Institute of Allergy and Asthma Research University of Zurich Davos Switzerland

Theramed Medical Center Brasov Romania

Translational Medicine Program Peter Gilgan Centre for Research and Learning Hospital for Sick Children Toronto ON Canada

Transylvania University Brasov Romania

University Hospital Montpellier Montpellier France

Woolcock Institute of Medical Research Woolcock Emphysema Centre University of Sydney Glebe NSW Australia

Zobrazit více v PubMed

Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus‐infected pneumonia. N Engl J Med. 2020;382(13):1199‐1207. PubMed PMC

Coronavirus disease (COVID‐2019) situation reports. Weekly Epidemiological Update and Weekly Operational Update. https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/situation‐reports. Accessed 21 Apr, 2020.

Asthma and Allergy Foundation of America (aafa). https://www.aafa.org/media/2631/respiratory‐illness‐symptoms‐chart‐coronavirus‐flu‐cold‐allergies.png. Accessed April 21, 2020.

Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS‐CoV‐2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574‐1581. PubMed PMC

Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy. 2020;75(7):1730‐1741. PubMed

WHO . Coronavirus disease (COVID‐19) technical guidance: Patient management. https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/technical‐guidance/patient‐management. Accessed April 21, 2020.

EAACI resource center COVID‐19. https://www.eaaci.org/4702. Accessed 16 May, 2020.

Dong X, Cao YY, Lu XX, et al. Eleven faces of coronavirus disease 2019. Allergy. 2020;75(7):1699‐1709. PubMed PMC

Vultaggio A, Agache I, Akdis CA, et al. Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement. Allergy. 2020;75:2764‐2774. 10.1111/all.14407 PubMed DOI PMC

Klimek L, Jutel M, Akdis C, et al. Handling of allergen immunotherapy in the COVID‐19 pandemic: An ARIA‐EAACI statement. Allergy. 2020;75(7):1546‐1554. PubMed PMC

Klimek L, Jutel M, Bousquet J, et al. Management of patients with chronic rhinosinusitis during the COVID‐19 pandemic ‐ An EAACI Position Paper. Allergy. 2021;76:677‐688. 10.1111/all.14629 PubMed DOI

Bousquet J, Anto JM, Iaccarino G, et al. group A, Is diet partly responsible for differences in COVID‐19 death rates between and within countries? Clin Transl Allergy. 2020;10:16. PubMed PMC

Bousquet J, Jutel M, Akdis CA, et al. ARIA‐EAACI statement on asthma and COVID‐19 (June 2, 2020). Allergy. 2021;76:689‐697. PubMed PMC

Cai Q, Huang D, Ou P, et al. COVID‐19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020;75(7):1742‐1752. PubMed

Zhang JJ, Cao YY, Dong X, et al. Distinct characteristics of COVID‐19 patients with initial rRT‐PCR‐positive and rRT‐PCR‐negative results for SARS‐CoV‐2. Allergy. 2020;75(7):1809‐1812. PubMed PMC

Sotgiu G, Gerli AG, Centanni S, et al. Advanced forecasting of SARS‐CoV‐2‐related deaths in Italy, Germany, Spain, and New York State. Allergy. 2020;75(7):1813‐1815. PubMed PMC

Gursel M, Gursel I. Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic? Allergy. 2020;75(7):1815‐1819. PubMed PMC

Ozdemir C, Kucuksezer UC, Tamay ZU. Is BCG vaccination affecting the spread and severity of COVID‐19? Allergy. 2020;75(7):1824‐1827. PubMed

Malipiero G, Paoletti G, Puggioni F, et al. An academic allergy unit during COVID‐19 pandemic in Italy. J Allergy Clin Immunol. 2020;146(1):227. PubMed PMC

Shaker MS, Oppenheimer J, Grayson M, et al. COVID‐19: Pandemic Contingency Planning for the Allergy and Immunology Clinic. J Allergy Clin Immunol Pract. 2020;8(5):1477‐1488. PubMed PMC

CDC.gov . Coronavirus Disease 2019; 2020. Available from: https://www.cdc.gov/. Accessed 21 Apr, 2020.

Liang M, Gao L, Cheng C, et al. Efficacy of face mask in preventing respiratory virus transmission: A systematic review and meta‐analysis. Travel Med Infect Dis 2020;36:101751. PubMed PMC

https://www.europeanrhinologicsociety.org. Accessed 21 Apr, 2020.

Van Gerven L, Hellings PW, Cox T, et al. Personal protection and delivery of rhinologic and endoscopic skull base procedures during the COVID‐19 outbreak. Rhinology 2020;58(3):289‐294. PubMed

WHO . Coronavirus disease (COVID‐19) pandemic; 2020. Available from https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019. Accessed 21 Apr, 2020.

European Centre for Disease Prevention and Control . Guidelines for the use of non‐pharmaceutical measures to delay and mitigate the impact of 2019‐nCoV. Stockholm: ECDC; 2020. https://www.ecdc.europa.eu/sites/default/files/documents/novel-coronavirus-guidelines-non-pharmaceutical-measures_0.pdf. Accessed 21 Apr, 2020.

Papadopoulos NG, Christodoulou I, Rohde G, et al. Viruses and bacteria in acute asthma exacerbations–a GA2 LEN‐DARE systematic review. Allergy. 2011;66(4):458‐468. PubMed PMC

Beale J, Jayaraman A, Jackson DJ, et al. Rhinovirus‐induced IL‐25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci Transl Med. 2014;6(256):256ra134. PubMed PMC

Edwards MR, Strong K, Cameron A, Walton RP, Jackson DJ, Johnston SL. Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness. J Allergy Clin Immunol. 2017;140(4):909‐920. PubMed PMC

Wollenberg A, Flohr C, Simon D, et al. European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2)‐infection and atopic dermatitis. J Eur Acad Dermatol Venereol. 2020;34(6):e241‐e242. PubMed

Du Y, Tu L, Zhu P, et al. Clinical Features of 85 Fatal Cases of COVID‐19 from Wuhan. A Retrospective Observational Study. Am J Respir Crit Care Med. 2020;201(11):1372‐1379. PubMed PMC

Bhatraju PK, Ghassemieh BJ, Nichols M, et al. Covid‐19 in Critically Ill Patients in the Seattle Region ‐ Case Series. N Engl J Med. 2020;382(21):2012‐2022. PubMed PMC

Garg S, Kim L, Whitaker M, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory‐Confirmed Coronavirus Disease 2019 ‐ COVID‐NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(15):458‐464. PubMed PMC

Jackson DJ, Busse WW, Bacharier LB, et al. Association of respiratory allergy, asthma, and expression of the SARS‐CoV‐2 receptor ACE2. J Allergy Clin Immunol. 2020;146(1):203‐206. PubMed PMC

Waibel KH, Bickel RA, Brown T. Outcomes From a Regional Synchronous Tele‐Allergy Service. J Allergy Clin Immunol Pract. 2019;7(3):1017‐1021. PubMed

Matricardi PM, Dramburg S, Alvarez‐Perea A, et al. The role of mobile health technologies in allergy care: An EAACI position paper. Allergy. 2020;75(2):259‐272. PubMed

Waller M, Stotler C. Telemedicine: a Primer. Curr Allergy Asthma Rep. 2018;18(10):54. PubMed

Pereira AM, Jácome C, Almeida R, Fonseca JA. How the Smartphone is Changing allergy Diagnostics. Curr Allergy Asthma Rep. 2018;18:69. PubMed

Bousquet J, Caimmi DP, Bedbrook A, et al. Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK‐rhinitis study. Allergy. 2017;72(6):857‐865. PubMed

Cuervo‐Pardo L, Barcena‐Blanch MA, Gonzalez‐Estrada A, Schroer B. Apps for food allergy: A critical assessment. J Allergy Clin Immunol Pract. 2015;3(6):980‐981. PubMed

Worm M, Reese I, Ballmer‐Weber B, et al. Guidelines on the management of IgE‐mediated food allergies: S2k‐Guidelines of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Medical Association of Allergologists (AeDA), the German Professional Association of Pediatricians (BVKJ), the German Allergy and Asthma Association (DAAB), German Dermatological Society (DDG), the German Society for Nutrition (DGE), the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS), the German Society for Oto‐Rhino‐Laryngology, Head and Neck Surgery, the German Society for Pediatric and Adolescent Medicine (DGKJ), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Society for Pneumology (DGP), the German Society for Pediatric Gastroenterology and Nutrition (GPGE), German Contact Allergy Group (DKG), the Austrian Society for Allergology and Immunology (AE‐GAI), German Professional Association of Nutritional Sciences (VDOE) and the Association of the Scientific Medical Societies Germany (AWMF). Allergo J Int. 2015;24:256‐293. PubMed PMC

Alvarez‐Perea A, Sánchez‐García S, Muñoz Cano R, Antolín‐Amérigo D, Tsilochristou O, Stukus DR. Impact Of "eHealth" in Allergic Diseases and Allergic Patients. J Investig Allergol Clin Immunol. 2019;29(2):94‐102. PubMed

Taylor L, Waller M, Portnoy JM. Telemedicine for allergy services to rural communities. J Allergy Clin Immunol Pract. 2019;7(8):2554‐2559. PubMed

Krishna MT, Knibb RC, Huissoon AP. Is there a role for telemedicine in adult allergy services? Clin Exp Allergy. 2016;46(5):668‐677. PubMed

Portnoy J, Waller M, Elliott T. Telemedicine in the Era of COVID‐19. J Allergy Clinical Immunol Pract. 2020;8(5):1489‐1491. PubMed PMC

https://www.theverge.com/2020/1/28/21082331/zoom‐vulnerability‐hacker‐eavesdrop‐security‐google‐hangouts‐skype‐checkpoint. Accessed 21 Apr, 2020.

https://www.fbi.gov/contact‐us/field‐offices/boston/news/press‐releases/fbi‐warns‐of‐teleconferencing‐and‐online‐classroom‐hijacking‐during‐covid‐19‐pandemic. Accessed 21 Apr, 2020.

https://eur‐lex.europa.eu/legal‐content/EN/TXT/PDF/?uri=CELEX:32016R0679&from=EN. Accessed 21 Apr, 2020.

https://www.whatsapp.com/legal/?lang=en#terms‐of‐service. Accessed 21 Apr, 2020.

https://products.office.com/en‐us/microsoft‐teams/group‐chat‐software. Accessed 21 Apr, 2020.

https://zoom.us. Accessed 21 Apr, 2020.

https://www.box.com/collaboration/document‐management. Accessed 21 Apr, 2020.

https://www.whatsapp.com. Accessed 21 Apr 2020.

https://slack.com. Accessed 21 Apr, 2020.

https://www.healthline.com/health/best‐telemedicine‐iphone‐android‐apps. Accessed 21 Apr, 2020.

Xie X, Li Y, Chwang ATY, Ho PL, Seto WH. How far droplets can move in indoor environments–revisiting the Wells evaporation‐falling curve. Indoor Air. 2007;17(3):211‐225. PubMed

Siegel JD, Rhinehart E, Jackson M, Chiarello L. Health Care Infection Control Practices Advisory Committee. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings. Am J Infect Control. 2007;35(10 Suppl 2):S65‐164. PubMed PMC

Cancer Care Goes Virtual in Response to COVID‐19. Cancer Discov. 2020;10(6):755. PubMed

Hopkins C, Surda P, Kumar N. Presentation of new onset anosmia during the COVID‐19 pandemic. Rhinology. 2020;58(3):295‐298. PubMed

Lechien JR, Chiesa‐Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild‐to‐moderate forms of the coronavirus disease (COVID‐19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020;277(8):2251‐2261. PubMed PMC

Glauser W. Proposed protocol to keep COVID‐19 out of hospitals. CMAJ. 2020;192(10):E264‐E265. PubMed PMC

Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis. Otolaryngol Head Neck Surg. 2020;163(1):3‐11. PubMed

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID‐19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239‐1242. PubMed

Lu D, Wang H, Yu R, Yang H, Zhao Y. Integrated infection control strategy to minimize nosocomial infection of coronavirus disease 2019 among ENT healthcare workers. J Hospital Infect. 2020;104(4):454‐455. PubMed PMC

Zou L, Ruan F, Huang M, et al. SARS‐CoV‐2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med. 2020;382(12):1177‐1179. PubMed PMC

World Health Organization . Rational Use of Personal Protective Equipment (PPE) for Coronavirus Disease 2019 (COVID‐19); 2020. https://apps.who.int/iris/bitstream/handle/10665/331498/WHO‐2019‐nCoV‐IPCPPE_use‐2020.2‐eng.pdf. Accessed 21 Apr, 2020.

Tran K, Cimon K, Severn M, Pessoa‐Silva C, Conly J. Aerosol‐generating procedures and risk of transmission of acute respiratory infections: a systematic review. CADTH Technol Overv. 2013;3(1):e3201. PubMed PMC

Diamant Z, Gauvreau GM, Cockcroft DW, et al. Inhaled allergen bronchoprovocation tests. J Allergy Clin Immunol. 2013;132(5):1045–1055. PubMed

Alving K, Diamant Z, Lucas S, et al. Point‐of‐care biomarkers in asthma management: Time to move forward. Allergy. 2020;75(4):995‐997. PubMed

Meselson M. Droplets and Aerosols in the Transmission of SARS‐CoV‐2. N Engl J Med. 2020;382(21):2063. PubMed PMC

Centers for Disease Control and Prevention . Interim Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated with Coronavirus Disease 2019 (COVID‐19). https://www.cdc.gov/coronavirus/2019‐ncov/lab/lab‐biosafety‐guidelines.html. Accessed April 19, 2020.

Practical information from Robert Koch Institute. https://www.rki.de/DE/Home/homepage_node.html. Accessed 21 Apr, 2020.

Practical information from World Health Organization. https://www.who.int/. Accessed 21 Apr, 2020.

Practical information from International Air Transport Association (IATA). https://www.iata.org/en/programs/cargo/dgr/. Accessed 21 Apr, 2020.

World Health Organization . Guidance on regulations for the transport of infectious substances 2019–2020. https://www.who.int/ihr/publications/WHO‐WHE‐CPI‐2019.20/en/. Accessed 21 Apr, 2020.

World Health Organization (WHO) . General procedures for inactivation of potentially infectious samples with ebola virus and other highly pathogenic viral agents. https://www.paho.org/hq/dmdocuments/2014/2014‐cha‐procedures‐inactivation‐ebola.pdf. Accessed 01 May, 2020.

Gangadharan D, Smith J, Weyant R. Biosafety Recommendations for Work with Influenza Viruses Containing a Hemagglutinin from the A/goose/Guangdong/1/96 Lineage. MMWR Recomm Rep. 2013;62(RR‐06):1‐7. PubMed

Aberer W, Bircher A, Romano A, et al. European Network for Drug Allergy (ENDA); EAACI interest group on drug hypersensitivity. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy. 2003;58(9):854‐863. PubMed

Romano A, Atanaskovic‐Markovic M, Barbaud A, et al. Towards a more precise diagnosis of hypersensitivity to beta‐lactams ‐ an EAACI position paper. Allergy. 2020;75(6):1300‐1315. PubMed

Kowalski ML, Agache I, Bavbek S, et al. Diagnosis and management of NSAID‐Exacerbated Respiratory Disease (N‐ERD)‐a EAACI position paper. Allergy. 2019;74(1):28‐39. PubMed

Muraro A, Lemanske RF Jr, Castells M, et al. Precision medicine in allergic disease‐food allergy, drug allergy, and anaphylaxis‐PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology. Allergy. 2017;72(7):1006‐1021. PubMed

Eiwegger T, Hung L, San Diego KE, O'Mahony L, Upton J. Recent developments and highlights in food allergy. Allergy. 2019;74(12):2355‐2367. PubMed

Chen Y, Chen L, Deng Q, et al. The presence of SARS‐CoV‐2 RNA in the feces of COVID‐19 patients. J Med Virol. 2020;92(7):833‐840. PubMed

Pettersson ME, Koppelman GH, Flokstra‐de Blok BMJ, Kollen BJ, Dubois AEJ. Prediction of the severity of allergic reactions to foods. Allergy. 2018;73(7):1532‐1540. PubMed PMC

Greuter T, Straumann A. Medical algorithm: Diagnosis and treatment of eosinophilic esophagitis in adults. Allergy. 2020;75(3):727‐730. PubMed PMC

Bonato G, Dioscoridi L, Mutignani M. Faecal‐oral transmission of SARS‐COV‐2: practical implications. Gastroenterology. 2020. 10.1053/j.gastro.2020.03.066 PubMed DOI PMC

Cianferoni A, Warren CM, Brown‐Whitehorn T, Schultz‐Matney F, Nowak‐Wegrzyn A, Gupta RS. Eosinophilic esophagitis and allergic comorbidities in a US‐population‐based study. Allergy. 2020;75(6):1466‐1469. PubMed PMC

Bousquet J, Akdis C, Jutel M, et al. Intranasal corticosteroids in allergic rhinitis in COVID‐19 infected patients: An ARIA‐EAACI statement. Allergy. 2020;75:2440‐2444. 10.1111/all.14302 PubMed DOI

Gelincik A, Brockow K, Çelik G, et al. Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19. Allergy. 2020;75:2775‐2793. 10.1111/all.14439 PubMed DOI PMC

Williams H, Robertson C, Stewart A, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. J Allergy Clin Immunol. 1999;103(1 Pt 1):125‐138. PubMed

Mortz CG, Andersen KE, Dellgren C, Barington T, Bindslev‐Jensen C. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy. 2015;70(7):836‐845. PubMed

Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Allergy. 2006;61(8):969‐987. PubMed

Wollenberg A, Barbarot S, Bieber T, et al. Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657‐682. PubMed

Seegräber M, Worm M, Werfel T, et al. Recurrent eczema herpeticum ‐ a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. J Eur Acad Dermatol Venereol. 2020;34(5):1074‐1079. PubMed

Advice for Dermatology HCPs during Covid‐19 Pandemic; 2020. Available from: https://www.bad.org.uk/. Accessed 22 Apr, 2020.

Ferrucci S, Romagnuolo M, Angileri L, Berti E, Tavecchio S. Safety of dupilumab in severe atopic dermatitis and infection of Covid‐19: two case reports. J Eur Acad Dermatol Venereol. 2020;34(7):e303‐e304. PubMed PMC

Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA(2)LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393‐1414. PubMed

Imbalzano E, Casciaro M, Quartuccio S, et al. Association between urticaria and virus infections: A systematic review. Allergy Asthma Proc. 2016;37(1):18‐22. PubMed

Recalcati S. Cutaneous manifestations in COVID‐19: a first perspective. J Eur Acad Dermatol Venereol. 2020;34(5):e212‐e213. PubMed

Hedou M, Carsuzaa F, Chary E, Hainaut E, Cazenave‐Roblot F, Masson Regnault M. Comment on "Cutaneous manifestations in COVID‐19: a first perspective " by Recalcati S. J Eur Acad Dermatol Venereol. 2020;34(7):e299‐e300. PubMed PMC

van Damme C, Berlingin E, Saussez S, Accaputo O. Acute urticaria with pyrexia as the first manifestations of a COVID‐19 infection. J Eur Acad Dermatol Venereol. 2020;34(7):e300‐e301. PubMed PMC

Venter C, Groetch M, Netting M, Meyer R. A patient‐specific approach to develop an exclusion diet to manage food allergy in infants and children. Clin Exp Allergy. 2018;48(2):121‐137. PubMed

Pajno GB, Fernandez‐Rivas M, Arasi S, et al. EAACI Guidelines on allergen immunotherapy: IgE‐mediated food allergy. Allergy. 2018;73(4):799‐815. PubMed

Sturm GJ, Varga EM, Roberts G, et al. EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy. Allergy. 2018;73(4):744‐764. PubMed

Cernadas JR, Brockow K, Romano A, et al. General considerations on rapid desensitization for drug hypersensitivity ‐ a consensus statement. Allergy. 2010;65(11):1357‐1366. PubMed

Alvarez‐Cuesta E, Madrigal‐Burgaleta R, Angel‐Pereira D, et al. Delving into cornerstones of hypersensitivity to antineoplastic and biological agents: value of diagnostic tools prior to desensitization. Allergy. 2015;70(7):784‐794. PubMed

Scherer K, Brockow K, Aberer W, et al. Desensitization in delayed drug hypersensitivity reactions – an EAACI position paper of the Drug Allergy Interest Group. Allergy. 2013;68(7):844‐852. PubMed

Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN‐γ and IL‐4. J Allergy Clin Immunol. 2012;130(5):1087‐1096. PubMed

Hirsch AG, Stewart WF, Sundaresan AS, et al. Nasal and sinus symptoms and chronic rhinosinusitis in a population‐based sample. Allergy. 2017;72(2):274‐281. PubMed PMC

Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID‐19 infection. A novel syndrome? Rhinology. 2020;58(3):299‐301. PubMed

Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and Ageusia: Common Findings in COVID‐19 Patients. Laryngoscope. 2020;130(7):1787. PubMed PMC

Fokkens WJ, Lund VJ, Hopkins C, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(Suppl S29):1‐464. PubMed

Puhakka T, Mäkelä MJ, Malmström K, et al. The common cold: effects of intranasal fluticasone propionate treatment. J Allergy Clin Immunol. 1998;101(6 Pt 1):726‐731. PubMed

Hox V, Lourijsen E, Jordens A, et al. Benefits and harm of systemic steroids for short‐ and long‐term use in rhinitis and rhinosinusitis: an EAACI position paper. Clin Transl Allergy. 2020;10:1. PubMed PMC

Muraro A, Roberts G, Halken S, et al. EAACI guidelines on allergen immunotherapy: Executive statement. Allergy. 2018;73(4):739‐743. PubMed

Pfaar O, Angier E, Muraro A, Halken S, Roberts G. Algorithms in allergen immunotherapy in allergic rhinoconjunctivitis. Allergy. 2020;75(9):2411‐2414. PubMed

Pfaar O, Worm M. AIT und COVID‐19. German Society of Allergy and Clinical Immunology (DGAKI). https://dgaki.de/gefaehrliche‐defizite‐in‐der‐allergologie‐bleibt‐der‐patient‐auf‐der‐strecke/. Accessed April 21, 2020.

Bourdin A, Bjermer L, Brightling C, et al. ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions. Eur Respir J. 2019;54(3):1900900. PubMed

Darveaux JI, Lemanske RF Jr. Infection‐related asthma. J Allergy Clin Immunol Pract. 2014;2(6):658‐663. PubMed PMC

Halpin DMG, Faner R, Sibila O, Badia JR, Agusti A. Do chronic respiratory diseases or their treatment affect the risk of SARS‐CoV‐2 infection? Lancet Respir Med. 2020;8(5):436‐438. PubMed PMC

Kaiser UB, Mirmira RG, Stewart PM. Our Response to COVID‐19 as Endocrinologists and Diabetologists. J Clin Endocrinol Metab. 2020;105(5):1‐3. PubMed PMC

American Academy of Allergy Asthma, and Immunology . COVID‐19 and asthma: What patients need to know; 2020. https://www.aaaai.org/conditions‐and‐treatments/library/asthma‐library/covid‐asthma. Accessed April 17, 2020.

Global Initiative for Asthma . Reccomendations for inhaled asthma controller medications; 2020. https://ginasthma.org/recommendations‐for‐inhaled‐asthma‐controller‐medications/. Accessed April 17, 2020.

European Respiratory Society . COVID‐19: Guidelines and recommendations directory; 2020. https://www.ersnet.org/covid‐19‐guidelines‐and‐recommendations‐directory. Accessed April 17, 2020.

National Institute for Health and Care Excellence. Coronavirus (COVID‐19); 2020. https://www.nice.org.uk/covid‐19. Accessed April 17, 2020.

Esquivel A, Busse WW, Calatroni A, et al. Effects of omalizumab on rhinovirus infections, illnesses, and exacerbations of asthma. Am J Respir Crit Care Med. 2017;196(8):985‐992. PubMed PMC

Teach SJ, Gill MA, Togias A, et al. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. J Allergy Clin Immunol. 2015;136(6):1476‐1485. PubMed PMC

Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054‐1062. PubMed PMC

Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS‐CoV‐2 pneumonia in Wuhan, China: a single‐centered, retrospective, observational study. Lancet Resp Med. 2020;8(5):475‐481. PubMed PMC

Singhal T. A review of coronavirus disease‐2019 (COVID‐19). Indian J Pediatr. 2020;87(4):281‐286. PubMed PMC

Zheng YY, Ma YT, Zhang JY, Xie X. COVID‐19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259‐260. PubMed PMC

Pfaar O, Agache I, Bergmann KC, et al. Placebo effects in allergen immunotherapy ‐ an EAACI Task Force Position Paper. Allergy. 2021;76:629‐647. 10.1111/all.14331 PubMed DOI

Kiecolt‐Glaser JK, Heffner KL, Glaser R, et al. How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitis. Psychoneuroendocrinology. 2009;34(5):670‐680. PubMed PMC

Vits S, Cesko E, Benson S, et al. Cognitive factors mediate placebo responses in patients with house dust mite allergy. PLoS One. 2013;8(11):e79576. PubMed PMC

Petrie KJ, Rief W. Psychobiological Mechanisms of Placebo and Nocebo Effects: Pathways to Improve Treatments and Reduce Side Effects. Annu Rev Psychol. 2019;70:599‐625. PubMed

Schedlowski M, Enck P, Rief W, Bingel U. Neuro‐Bio‐Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice. Pharmacol Rev. 2015;67(3):697‐730. PubMed

Kemeny ME, Schedlowski M. Understanding the interaction between psychosocial stress and immune‐related diseases: a stepwise progression. Brain Behav Immun. 2007;21(8):1009‐1018. PubMed

Dantzer R, Cohen S, Russo SJ, Dinan TG. Resilience and immunity. Brain Behav Immun. 2018;74:28‐42. PubMed PMC

Food and Drug Administration . Clinical Trial Conduct During the COVID‐19 Pandemic. https://www.fda.gov/drugs/coronavirus‐covid‐19‐drugs/clinical‐trial‐conduct‐during‐covid‐19‐pandemic. Accessed April 19, 2020.

European Medicines Agency . Guidance on the Management of Clinical Trials during the COVID‐19 (Coronavirus) pandemic. https://ec.europa.eu/health/sites/health/files/files/eudralex/vol‐10/guidanceclinicaltrials_covid19_en.pdf. Accessed April 19, 2020.

Shrestha GS, Paneru HR, Vincent JL. Precision medicine for COVID‐19: a call for better clinical trials. Crit Care. 2020;24(1):282. PubMed PMC

Bonini S, Maltese G. COVID‐19 Clinical trials: quality matters more than quantity. Allergy. 2020;75:2542‐2547. 10.1111/all.14409 PubMed DOI PMC

Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2 LEN consensus

A compendium answering 150 questions on COVID-19 and SARS-CoV-2