BACKGROUND: Pre- and post-partum depression is a common mood disorder with detrimental effects on both mother and child. The aim of the proposed review is to summarize evidence related to the effects of both pre- and post-partum depression on child behavior and development from birth to preschool age. In particular, our review will address mutual relations between pre- and post-partum depression in order to determine whether pre- and post-partum depression predict child psychological outcomes independently, whether there is an effect of timing of depression on child outcomes, whether pre- and post-partum depression interact to affect child outcomes, and whether the effect of pre-partum depression is mediated by depression after child's birth. METHODS: We will include prospective longitudinal studies that report data about the effects of both pre- and post-partum depression on child psychological outcomes as published in peer-reviewed academic journals since January 1998. We will search EMBASE, MEDLINE, PsycARTICLES, PsycINFO, ISI Web of Science, Scopus, and Wiley Online databases to identify original research articles written in English. Two independent reviewers will screen search results in two stages: (i) titles and abstracts and (ii) full text. The first one will extract data into tables, while the latter will verify whether the data extracted are correct. We will assess the risk of bias in the selected studies using the Critical Appraisal Skills Programme (CASP), Cohort Study Checklist. The results of the review will be reported in a narrative form. If there are sufficient data available, a meta-analysis will be conducted using metaSEM package in R. DISCUSSION: The proposed review will be the first systematic review summarizing the effects of both pre- and post-partum depression on child psychological development and behavior from birth to preschool age. The results of such a review may contribute to a better understanding of mutual relations between pre- and post-partum depression in their effects on child outcomes. They may also shed light on what periods in early human development are most vulnerable to the effects of maternal depression. TRIAL REGISTRATION: PROSPERO CRD42018106269.

Department of Philosophy and History of Science Faculty of Science Charles University Viničná 5 128 44 Prague 2 Czech Republic

Department of Psychology Faculty of Arts Charles University Celetná 20 116 42 Prague 1 Czech Republic

Institute for Research on Children Youth and Family Faculty of Social Studies Masaryk University Joštova 10 602 00 Brno Czech Republic

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Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T. Perinatal depression - a systematic review of prevalence and incidence. Obstet Gynecol. 2005;106(5):1071–1083. doi: 10.1097/01.AOG.0000183597.31630.db. PubMed DOI

Gelaye B, Rondon MB, Araya R, Williams MA. Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries. Lancet Psychiatry. 2016;3(10):973–982. doi: 10.1016/S2215-0366(16)30284-X. PubMed DOI PMC

Hahn-Holbrook J, Cornwell-Hinrichs T, Anaya I. Economic and health predictors of national postpartum depression prevalence: a systematic review, meta-analysis, and meta-regression of 291 studies from 56 countries. Front Psychiatry. 2018;8. PubMed PMC

Chaudron LH, Szilagyi PG, Kitzman HJ, Wadkins HIM, Conwell Y. Detection of postpartum depressive symptoms by screening at well-child visits. Pediatrics. 2004;113(3):551–558. doi: 10.1542/peds.113.3.551. PubMed DOI

American Psychiatric Association D-TF . Diagnostic and statistical manual of mental disorders: DSM-5™. 5. Arlington, VA, US: American Psychiatric Publishing, Inc.; 2013.

Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, et al. Perinatal depression: prevalence, screening accuracy, and screening outcomes: summary. AHRQ evidence report summaries: Agency for Healthcare Research and Quality (US); 2005. PubMed PMC

Kim DR, Epperson CN, Weiss AR, Wisner KL. Pharmacotherapy of postpartum depression: an update. Expert Opin Pharmacother. 2014;15(9):1223–34. PubMed PMC

Wisner KL, Moses-Kolko EL, Sit DK. Postpartum depression: a disorder in search of a definition. Arch Womens Ment Health. 2010;13(1):37–40. doi: 10.1007/s00737-009-0119-9. PubMed DOI PMC

Cerimele JM, Vanderlip ER, Croicu CA, Melville JL, Russo J, Reed SD, et al. Presenting symptoms of women with depression in an obstetrics and gynecology setting. Obstet Gynecol. 2013;122(2 0 1):313. doi: 10.1097/AOG.0b013e31829999ee. PubMed DOI PMC

Eckerdal P, Georgakis MK, Kollia N, Wikstrom AK, Hogberg U, Skalkidou A. Delineating the association between mode of delivery and postpartum depression symptoms: a longitudinal study. Acta Obstet Gynecol Scand. 2018;97(3):301–311. doi: 10.1111/aogs.13275. PubMed DOI

Wisner KL, Parry BL, Piontek CM. Clinical practice. Postpartum depression. N Engl J Med. 2002;347(3):194–9. PubMed

Beck CT. Predictors of postpartum depression - an update. Nurs Res. 2001;50(5):275–285. doi: 10.1097/00006199-200109000-00004. PubMed DOI

Ohara MW, Swain AM. Rates and risk of postpartum depression - a meta-analysis. Int Rev Psychiatry. 1996;8(1):37–54. doi: 10.3109/09540269609037816. DOI

Robertson E, Grace S, Wallington T, Stewart DE. Antenatal risk factors for postpartum depression: a synthesis of recent literature. Gen Hosp Psychiatry. 2004;26(4):289–95. PubMed

Field T. Prenatal depression effects on early development: a review. Infant Behav Dev. 2011;34(1):1–14. doi: 10.1016/j.infbeh.2010.09.008. PubMed DOI

Underwood L, Waldie K, D’Souza S, Peterson ER, Morton S. A review of longitudinal studies on antenatal and postnatal depression. Arch Womens Ment Health. 2016;19(5):711–20. PubMed

Bauer A, Pawlby S, Plant DT, King D, Pariante CM, Knapp M. Perinatal depression and child development: exploring the economic consequences from a South London cohort. Psychol Med. 2015;45(1):51–61. doi: 10.1017/S0033291714001044. PubMed DOI PMC

Park M, Brain U, Grunau RE, Diamond A, Oberlander TF. Maternal depression trajectories from pregnancy to 3 years postpartum are associated with children's behavior and executive functions at 3 and 6 years. Arch Womens Ment Health. 2018;21(3):353–363. doi: 10.1007/s00737-017-0803-0. PubMed DOI

Tuovinen S, Lahti-Pulkkinen M, Girchenko P, Lipsanen J, Lahti J, Heinonen K, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018;35(8):732–741. doi: 10.1002/da.22756. PubMed DOI

Stein A, Pearson RM, Goodman SH, Rapa E, Rahman A, McCallum M, et al. Effects of perinatal mental disorders on the fetus and child. Lancet. 2014;384(9956):1800–1819. doi: 10.1016/S0140-6736(14)61277-0. PubMed DOI

Davis EP, Snidman N, Wadhwa PD, Glynn LM, Schetter CD, Sandman CA. Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy. 2004;6(3):319–331. doi: 10.1207/s15327078in0603_1. DOI

Werner EA, Myers MM, Fifer WP, Cheng B, Fang YX, Allen R, et al. Prenatal predictors of infant temperament. Dev Psychobiol. 2007;49(5):474–84. PubMed

Feldman R, Granat A, Pariente C, Kanety H, Kuint J, Gilboa-Schechtman E. Maternal depression and anxiety across the postpartum year and infant social engagement, fear regulation, and stress reactivity. J Am Acad Child Adolesc Psychiatry. 2009;48(9):919–27. . PubMed

Tronick EZ, Gianino AF., Jr The transmission of maternal disturbance to the infant. New Dir Child Dev. 1986;34:5–11. doi: 10.1002/cd.23219863403. PubMed DOI

Manian N, Bornstein MH. Dynamics of emotion regulation in infants of clinically depressed and nondepressed mothers. J Child Psychol Psychiatry. 2009;50(11):1410–8. PubMed PMC

McMahon CA, Barnett B, Kowalenko NM, Tennant CC. Maternal attachment state of mind moderates the impact of postnatal depression on infant attachment. J Child Psychol Psychiatry. 2006;47(7):660–9. PubMed

Pawlby S, Hay DF, Sharp D, Waters CS, O'Keane V. Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study. J Affect Disord. 2009;113(3):236–43. PubMed

Ponder KL, Salisbury A, McGonnigal B, Laliberte A, Lester B, Padbury JF. Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: implications for fetal programming. Dev Psychobiol. 2011;53(7):711–23. PubMed PMC

Forman DR, O'Hara MW, Stuart S, Gorman LL, Larsen KE, Coy KC. Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship. Dev Psychopathol. 2007;19(2):585–602. PubMed

Apter-Levi Y, Pratt M, Vakart A, Feldman M, Zagoory-Sharon O, Feldman R. Maternal depression across the first years of life compromises child psychosocial adjustment; relations to child HPA-axis functioning. Psychoneuroendocrinology. 2016;64:47–56. doi: 10.1016/j.psyneuen.2015.11.006. PubMed DOI

Feldman R, Eidelman AI. Biological and environmental initial conditions shape the trajectories of cognitive and social-emotional development across the first years of life. Dev Sci. 2009;12(1):194–200. PubMed

Jacques N, de Mola CL, Joseph G, Mesenburg MA, da Silveira MF. Prenatal and postnatal maternal depression and infant hospitalization and mortality in the first year of life: a systematic review and meta-analysis. J Affect Disord. 2019;243:201–8. PubMed

Stewart RC. Maternal depression and infant growth–a review of recent evidence. Matern Child Nutr. 2007;3(2):94–107. doi: 10.1111/j.1740-8709.2007.00088.x. PubMed DOI PMC

Kingston D, Tough S. Prenatal and postnatal maternal mental health and school-age child development: a systematic review. Matern Child Health J. 2014;18(7):1728–41. PubMed

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;349:g7647. PubMed

Critical Appraisal Skills Programme. CASP (Cohort Study) Checklist. 2018. [online]Available at: https://casp-uk.net/casp-tools-checklists/. Accessed 11 Jan 2020.

Shadish WR. Meta-analysis and the exploration of causal mediating processes: a primer of examples, methods, and issues. Psychol Methods. 1996;1(1):47. doi: 10.1037/1082-989X.1.1.47. DOI

Sheng Z, Kong W, Cortina JM, Hou S. Analyzing matrices of meta-analytic correlations: current practices and recommendations. Res Synth Methods. 2016;7(2):187–208. PubMed

Cheung MW-L, Chan W. Meta-analytic structural equation modeling: a two-stage approach. Psychol Methods. 2005;10(1):40. doi: 10.1037/1082-989X.10.1.40. PubMed DOI

Cheung MW-L. Fixed-and random-effects meta-analytic structural equation modeling: Examples and analyses in R. Behav Res Methods. 2014;46(1):29–40. doi: 10.3758/s13428-013-0361-y. PubMed DOI

Cheung MWL, Cheung SF. Random-effects models for meta-analytic structural equation modeling: review, issues, and illustrations. Res Synth Methods. 2016;7(2):140–55. PubMed

Jak S. Meta-analytic structural equation modelling: Springer; 2015.

Team RC. R: A language and environment for statistical computing. 2013.

Cheung MW-L. metaSEM: An R package for meta-analysis using structural equation modeling. Front Psychol. 2015;5:1521. doi: 10.3389/fpsyg.2014.01521. PubMed DOI PMC