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PubMed

Záznam pochází z PubMed

More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

Chemical senses. 2020 Oct 09 ; 45 (7) : 609-622.

Chem Senses
ISSN 1464-3553 | 0379-864X
Zdroj

Jazyk angličtina Země Velká Británie, Anglie Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid32564071

Grantová podpora
R56 DC016921 NIDCD NIH HHS - United States
U01 DC019578 NIDCD NIH HHS - United States
R01 DC000566 NIDCD NIH HHS - United States
R01 DC014253 NIDCD NIH HHS - United States
T32 DC000014 NIDCD NIH HHS - United States

Online Plný text

PubMed 32564071
PubMed Central PMC7337664
DOI 10.1093/chemse/bjaa041
PII: 5860460
Knihovny.cz E-zdroje

Klíčová slova
head and neck surgery, olfaction, somatosensation,
MeSH
Betacoronavirus izolace a purifikace MeSH
chuť MeSH
čich MeSH
COVID-19 MeSH
dospělí MeSH
koronavirové infekce komplikace diagnóza virologie MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
pandemie MeSH
poruchy chuti etiologie virologie MeSH
poruchy čichu etiologie virologie MeSH
průzkumy a dotazníky MeSH
SARS-CoV-2 MeSH
senioři MeSH
somatosenzorické poruchy etiologie virologie MeSH
virová pneumonie komplikace diagnóza virologie MeSH
zpráva o sobě MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

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