Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32717439
DOI
10.1016/j.jinorgbio.2020.111160
PII: S0162-0134(20)30188-4
Knihovny.cz E-zdroje
- Klíčová slova
- Anti-cancer, Apoptosis, Cobalt(II) complexes, Flufenamic acid, NSAID, Niflumic acid,
- MeSH
- apoptóza účinky léků MeSH
- autofagie účinky léků MeSH
- fenantroliny chemická syntéza farmakologie MeSH
- kobalt chemie MeSH
- komplexní sloučeniny chemická syntéza farmakologie MeSH
- kontrolní body fáze G1 buněčného cyklu účinky léků MeSH
- kyselina flufenamová analogy a deriváty farmakologie MeSH
- lidé MeSH
- ligandy MeSH
- molekulární struktura MeSH
- nádorové buněčné linie MeSH
- protinádorové látky chemická syntéza farmakologie MeSH
- screeningové testy protinádorových léčiv MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- bathocuproine MeSH Prohlížeč
- fenantroliny MeSH
- kobalt MeSH
- komplexní sloučeniny MeSH
- kyselina flufenamová MeSH
- ligandy MeSH
- protinádorové látky MeSH
Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy. Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected.
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