Stress, glucocorticoid signaling pathway, and metabolic disorders

. 2020 Sep-Oct ; 14 (5) : 1273-1280. [epub] 20200709

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid32755820
Odkazy

PubMed 32755820
DOI 10.1016/j.dsx.2020.06.038
PII: S1871-4021(20)30207-1
Knihovny.cz E-zdroje

BACKGROUND AND AIMS: Glucocorticoids and the GR serve as an essential molecular mediator of stress and different physiologic processes. This review summarizes main findings from studies on the role of the GC/GR signaling in the modulation of genes for nutrient processing by the different organs involved in metabolic diseases. METHODS: Descriptive review of relevant papers known to the author was conducted. RESULTS: Several high-throughput screenings in the past 15 years have identified potential GR DNA-binding regions in different cell types with genes that are annotated to be important for the control of metabolism. Transcriptional regulation of these GC-responsive genes provides links between the hypothalamic-pituitary-adrenal axis (HPA) and systemic energy homeostasis in both physiological and pathophysiological states. Future studies must reconsider the use of agonist, the utilization of animal models of stress and metabolic disorders, and validation in humans. CONCLUSION: This review recapitulates the significant role of the GC/GR signaling in molecular metabolic control and metabolic disorders. Potential future research focus and optimizations have also been identified.

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