Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations
Status PubMed-not-MEDLINE Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
32834500
PubMed Central
PMC7309926
DOI
10.1016/j.tifs.2020.06.010
PII: S0924-2244(20)30511-2
Knihovny.cz E-zdroje
- Klíčová slova
- CS, chitosan, Dietary fiber, Encapsulation, FOS, Fructooligosaccharide, Formulations, GIT, Gastro intestinal tract, GO, gum odina, Gut micro-biota, Human health, In, Inulin, MD, maltodextrin, OL, oligofructose, OSA, octenyl-succinic anhydride, PS, potato starch, PSY, plantago psyllium, Prebiotics,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
BACKGROUND: Dietary fibers (DFs) are known as potential formulations in human health due to their beneficial effects in control of life-threatening chronic diseases including cardiovascular disease (CVD), diabetes mellitus, obesity and cancer. In recent decades scientists around the globe have shown tremendous interest to evaluate the interplay between DFs and gastrointestinal (GIT) microbiota. Evidences from various epidemiological and clinical trials have revealed that DFs modulate formation and metabolic activities of the microbial communities residing in the human GIT which in turn play significant roles in maintaining health and well-being. Furthermore, interestingly, a rapidly growing literature indicates success of DFs being prebiotics in immunomodulation, namely the stimulation of innate, cellular and humoral immune response, which could also be linked with their significant roles in modulation of the probiotics (live beneficial microorganisms). SCOPE AND APPROACH: The main focus of the current review is to expressively highlight the importance of DFs being prebiotics in human health in association with their influence on gut microbiota. Now in order to significantly achieve the promising health benefits from these prebiotics, it is aimed to develop novel formulations to enhance and scale up their efficacy. Therefore, finally, herein unlike previously published articles, we highlighted different kinds of prebiotic and probiotic formulations which are being regarded as hot research topics among the scientific community now a days. CONCLUSION: The information in this article will specifically provide a platform for the development of novel functional foods the demands for which has risen drastically in recent years.
College of Food Science and Technology Huazhong Agricultural University Wuhan 430070 China
College of Life Science Xinyang Normal University Xinyang 464000 People's Republic of China
Zobrazit více v PubMed
AACCI, American Association of Cereal Chemists International Whole grain definition. Cereal Foods World. 1999;45:79.
Akbari E., et al. Effect of probiotic supplementation on cognitive function and metabolic status in alzheimer's disease: A randomized, double-blind and controlled trial. Frontiers in Aging Neuroscience. 2016;8:256. PubMed PMC
Alvarez-Sabatel S., de Marañón I.M., Arboleya J.-C. Impact of oil and inulin content on the stability and rheological properties of mayonnaise-like emulsions processed by rotor-stator homogenisation or high pressure homogenisation (HPH) Innovative Food Science & Emerging Technologies. 2018;48:195–203.
Angelino D., et al. Glucose-and lipid-related biomarkers are affected in healthy obese or hyperglycemic adults consuming a whole-grain pasta enriched in prebiotics and probiotics: A 12-week randomized controlled trial. Journal of Nutrition. 2019;149(10):1714–1723. PubMed
Arabzadegan N., Daneshzad E., Fatahi S., Moosavian S.P., Surkan P.J., Azadbakht L. Bulimia and Obesity; 2019. Effects of dietary whole grain, fruit, and vegetables on weight and inflammatory biomarkers in overweight and obese women. Eating and Weight Disorders-Studies on Anorexia. PubMed
Baliou S., Adamaki M., Spandidos D.A., Kyriakopoulos A.M., Christodoulou I., Zoumpourlis V. The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis. World Academy of Sciences Journal. 2019;1(1):3–19.
Barichella M., et al. Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT. Neurology. 2016;87(12):1274–1280. PubMed
Barragán Martínez L.P., et al. Probiotication of cooked sausages employing agroindustrial coproducts as prebiotic co‐encapsulant in ionotropic alginate–pectin gels. International Journal of Food Science and Technology. 2019;55(3):1088–1096.
Benton D., Young H.A. Reducing calorie intake may not help you lose body weight. Perspectives on Psychological Science : A Journal of the Association for Psychological Science. 2017;12(5):703–714. doi: 10.1177/1745691617690878. PubMed DOI PMC
den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325–2340. doi: 10.1194/jlr.R036012. PubMed DOI PMC
Biesiekierski J.R., Jalanka J., Staudacher H.M. Can gut microbiota composition predict response to dietary treatments? Nutrients. 2019;11(5):1134. PubMed PMC
Bindels L.B., Delzenne N.M., Cani P.D., Walter J. Towards a more comprehensive concept for prebiotics. Nature Reviews Gastroenterology & Hepatology. 2015;12(5):303. PubMed
Calligaris S., et al. Potential application of monoglyceride structured emulsions as delivery systems of probiotic bacteria in reduced saturated fat ice cream. Lebensmittel-Wissenschaft & Technologie. 2018;96:329–334.
Campelo-Felix P.H., et al. Prebiotic carbohydrates: Effect on reconstitution, storage, release, and antioxidant properties of lime essential oil microparticles. Journal of Agricultural and Food Chemistry. 2017;65(2):445–453. PubMed
Canfora E.E., Meex R.C., Venema K., Blaak E.E. Gut microbial metabolites in obesity, NAFLD and T2DM. Nature Reviews Endocrinology. 2019;15(5):261–273. PubMed
Cassani L., et al. Improving quality parameters of functional strawberry juices: Optimization of prebiotic fiber enrichment and geraniol treatment. Food and Bioprocess Technology. 2018;11(11):2110–2124.
Chambers E.S., Preston T., Frost G., Morrison D.J. Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health. Current Nutrition Reports. 2018;7(4):198–206. PubMed PMC
Chau K., et al. Probiotics for infantile colic: A randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. The Journal of Pediatrics. 2015;166(1):74–78. e71. PubMed
Chávarri M., et al. Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions. International Journal of Food Microbiology. 2010;142(1-2):185–189. PubMed
Conlon M.A., Bird A.R. The impact of diet and lifestyle on gut microbiota and human health. Nutrients. 2015;7(1):17–44. PubMed PMC
Davani-Davari D., Negahdaripour M., Karimzadeh I., Seifan M., Mohkam M., Masoumi S.J., et al. Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods (Basel, Switzerland) 2019;8(3):92. doi: 10.3390/foods8030092. PubMed DOI PMC
De Filippo C., Cavalieri D., Di Paola M., Ramazzotti M., Poullet J.B., Massart S.…Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences. 2010;107(33):14691–14696. PubMed PMC
Dewulf E., Cani P., Claus S., Neyrinck A., Puylaert P., Glenn G.…Delzenne N. INULIN-TYPE fructans with prebiotic properties lessen endotoxemia and modulate host metabolism by changing gut microbiota composition in obese women: 749 accepted poster. Obesity Facts. 2012;5:200–201.
Dewulf E.M., Cani P.D., Neyrinck A.M., Possemiers S., Van Holle A., Muccioli G.G.…Sohet F.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 2011;22(8):712–722. PubMed
Dilli D., et al. The propre-save study: Effects of probiotics and prebiotics alone or combined on necrotizing enterocolitis in very low birth weight infants. The Journal of Pediatrics. 2015;166(3):545–551. e541. PubMed
Esmaeilnejad Moghadam B., Keivaninahr F., Fouladi M., Rezaei Mokarram R., Nazemi A. Inulin addition to yoghurt: Prebiotic activity, health effects and sensory properties. International Journal of Dairy Technology. 2019;72(2):183–198.
Famouri F., et al. Effects of probiotics on nonalcoholic fatty liver disease in obese children and adolescents. Journal of Pediatric Gastroenterology and Nutrition. 2017;64(3):413–417. PubMed
Felisberto M.H.F., et al. Effect of prebiotic ingredients on the rheological properties and microstructure of reduced-sodium and low-fat meat emulsions. LWT-Food Science and Technology. 2015;60(1):148–155.
Gao F., Lv Y., Long J., Chen J., He J., Ruan X., et al. Natural fermentation product butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet. Frontiers in Pharmacology. 2019;10:1040. PubMed PMC
Gibson G.R., Scott K.P., Rastall R.A., Tuohy K.M., Hotchkiss A., Dubert-Ferrandon A.…Loh G. Dietary prebiotics: Current status and new definition. Food Science & Technology Bulletin: Functional Foods. 2010;7(1):1–19.
Glisic M., Baltic M., Glisic M., Trbovic D., Jokanovic M., Parunovic N., et al. Inulin‐based emulsion‐filled gel as a fat replacer in prebiotic‐and PUFA‐enriched dry fermented sausages. International Journal of Food Science and Technology. 2019;54(3):787–797.
Gomes A.C., et al. The additional effects of a probiotic mix on abdominal adiposity and antioxidant status: A double‐blind, randomized trial. Obesity. 2017;25(1):30–38. PubMed
Gong L., Cao W., Chi H., Wang J., Zhang H., Liu J., et al. Whole cereal grains and potential health effects: Involvement of the gut microbiota. Food Research International. 2018;103:84–102. PubMed
Gong L., Wang T., Sun C., Wang J., Sun B. Whole barley prevents obesity and dyslipidemia without the involvement of the gut microbiota in germ free C57BL/6J obese mice. Food and Function. 2019;10(11):7498–7508. PubMed
Gonzalez-Garcia R.A., McCubbin T., Navone L., Stowers C., Nielsen L.K., Marcellin E. Microbial propionic acid production. Fermentation. 2017;3(2):21.
Goto H., Sagitani A., Ashida N., Kato S., Hirota T., Shinoda T., et al. Anti-influenza virus effects of both live and non-live Lactobacillus acidophilus L-92 accompanied by the activation of innate immunity. British Journal of Nutrition. 2013;110(10):1810–1818. PubMed
Grabitske H.A., Slavin J.L. Gastrointestinal effects of low-digestible carbohydrates. Critical Reviews in Food Science and Nutrition. 2009;49(4):327–360. doi: 10.1080/10408390802067126. PubMed DOI
Greenblum S., Turnbaugh P.J., Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proceedings of the National Academy of Sciences. 2012;109(2):594–599. PubMed PMC
Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Annual Review of Immunology. 2011;29:415–445. PubMed
Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C. Definition of metabolic syndrome. Circulation. 2004;109(3):433–438. doi: 10.1161/01.CIR.0000111245.75752.C6. PubMed DOI
Guimarães J.T., et al. Physicochemical changes and microbial inactivation after high-intensity ultrasound processing of prebiotic whey beverage applying different ultrasonic power levels. Ultrasonics Sonochemistry. 2018;44:251–260. PubMed
Ha H.-K., et al. Physicochemical characterization and potential prebiotic effect of whey protein isolate/inulin nano complex. Korean Journal for Food Science of Animal Resources. 2016;36(2):267. PubMed PMC
Han S.-F., Jiao J., Zhang W., Xu J.-Y., Zhang W., Fu C.-L., et al. Lipolysis and thermogenesis in adipose tissues as new potential mechanisms for metabolic benefits of dietary fiber. Nutrition. 2017;33:118–124. PubMed
Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B., et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology. 2014;11(8):506–514. PubMed
Hipsley E.H. Dietary “fibre” and pregnancy toxaemia. British Medical Journal. 1953;2(4833):420. PubMed PMC
Hod K., et al. A double‐blind, placebo‐controlled study to assess the effect of a probiotic mixture on symptoms and inflammatory markers in women with diarrhea‐predominant IBS. Neuro-Gastroenterology and Motility. 2017;29(7) PubMed
Holscher H.D., Bauer L.L., Gourineni V., Pelkman C.L., Fahey G.C., Jr., Swanson K.S. Agave inulin supplementation affects the fecal microbiota of healthy adults participating in a randomized, double-blind, placebo-controlled, crossover trial. Journal of Nutrition. 2015;145(9):2025–2032. PubMed
Hooda S., Boler B.M.V., Serao M.C.R., Brulc J.M., Staeger M.A., Boileau T.W.…Swanson K.S. 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber. Journal of Nutrition. 2012;142(7):1259–1265. PubMed
Hui S., Liu K., Lang H., Liu Y., Wang X., Zhu X., et al. Comparative effects of different whole grains and brans on blood lipid: A network meta-analysis. European Journal of Nutrition. 2019;58(7):2779–2787. PubMed PMC
Islek A., Sayar E., Yilmaz A., Baysan B.O., Mutlu D., Artan R. The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children. Turkish Journal of Gastroenterology. 2014;25(6):628–633. PubMed
Javadi L., et al. The effect of probiotic and/or prebiotic on liver function tests in patients with nonalcoholic fatty liver disease: A double blind randomized clinical trial. Iranian Red Crescent Medical Journal. 2017;19(4)
Javadi L., et al. 2018. Correction: The potential role of probiotics or/and prebiotic on serum lipid profile and insulin resistance in non-alcoholic fatty liver disease: A double blind randomized clinical trial.
Jena A.K., et al. Development of lamivudine containing multiple emulsions stabilized by gum odina. Future Journal of Pharmaceutical Sciences. 2018;4(1):71–79.
Jensen M.K., Koh-Banerjee P., Franz M., Sampson L., Grønbaek M., Rimm E.B. Whole grains, bran, and germ in relation to homocysteine and markers of glycemic control, lipids, and inflammation 1. American Journal of Clinical Nutrition. 2006;83(2):275–283. doi: 10.1093/ajcn/83.2.275. PubMed DOI
Jesch E.D., Carr T.P. Food ingredients that inhibit cholesterol absorption. Preventive Nutrition and Food Science. 2017;22(2):67–80. doi: 10.3746/pnf.2017.22.2.67. PubMed DOI PMC
Karimi R., Azizi M.H., Ghasemlou M., Vaziri M. Application of inulin in cheese as prebiotic, fat replacer and texturizer: A review. Carbohydrate Polymers. 2015;119:85–100. PubMed
Kazemi A., et al. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clinical Nutrition. 2019;38(2):522–528. PubMed
Khachatryan Z.A., Ktsoyan Z.A., Manukyan G.P., Kelly D., Ghazaryan K.A., Aminov R.I. Predominant role of host genetics in controlling the composition of gut microbiota. PloS One. 2008;3(8) PubMed PMC
Khani S., Motamedifar M., Golmoghaddam H., Hosseini H.M., Hashemizadeh Z. In vitro study of the effect of a probiotic bacterium Lactobacillus rhamnosus against herpes simplex virus type 1. Brazilian Journal of Infectious Diseases. 2012;16(2):129–135. PubMed PMC
Khorasani A.C., Shojaosadati S.A. Starch-and carboxymethylcellulose-coated bacterial nanocellulose-pectin bionanocomposite as novel protective prebiotic matrices. Food Hydrocolloids. 2017;63:273–285.
Kikuchi Y., Nozaki S., Makita M., Yokozuka S., Fukudome S.-i., Yanagisawa T., et al. Effects of whole grain wheat bread on visceral fat obesity in Japanese subjects: A randomized double-blind study. Plant Foods for Human Nutrition. 2018;73(3):161–165. PubMed
King D.E., Egan B.M., Woolson R.F., Mainous A.G., 3rd, Al-Solaiman Y., Jesri A. Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. Archives of Internal Medicine. 2007;167(5):502–506. doi: 10.1001/archinte.167.5.502. PubMed DOI
Koecher K.J., McKeown N.M., Sawicki C.M., Menon R.S., Slavin J.L. Effect of whole-grain consumption on changes in fecal microbiota: A review of human intervention trials. Nutrition Reviews. 2019;77(7):487–497. PubMed
Koh A., De Vadder F., Kovatcheva-Datchary P., Bäckhed F. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell. 2016;165(6):1332–1345. doi: 10.1016/j.cell.2016.05.041. PubMed DOI
Kopf J.C., Suhr M.J., Clarke J., Eyun S.-i., Riethoven J.-J.M., Ramer-Tait A.E., et al. Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: A randomized controlled trial. Nutrition Journal. 2018;17(1):72. PubMed PMC
Korcz E., Kerényi Z., Varga L. Dietary fibers, prebiotics, and exopolysaccharides produced by lactic acid bacteria: Potential health benefits with special regard to cholesterol-lowering effects. Food and Function. 2018;9(6):3057–3068. PubMed
Krithika B., Preetha R. Formulation of protein based inulin incorporated synbiotic nanoemulsion for enhanced stability of probiotic. Materials Research Express. 2019;6(11):114003.
Kunzmann A.T., Coleman H.G., Huang W.-Y., Kitahara C.M., Cantwell M.M., Berndt S.I. Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. American Journal of Clinical Nutrition. 2015;102(4):881–890. doi: 10.3945/ajcn.115.113282. PubMed DOI PMC
Larsen N., Vogensen F.K., Van Den Berg F.W., Nielsen D.S., Andreasen A.S., Pedersen B.K.…Jakobsen M. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PloS One. 2010;5(2) PubMed PMC
Li F., et al. Developing emulsion gels by incorporating Jerusalem artichoke inulin and investigating their lipid oxidative stability. Food Production, Processing and Nutrition. 2020;2(1):1–11.
Lim J.J., Poppitt S.D. How satiating are the ‘Satiety'Peptides: A problem of pharmacology versus physiology in the development of novel foods for regulation of food intake. Nutrients. 2019;11(7):1517. PubMed PMC
Li S., Yu W., Guan X., Huang K., Liu J., Liu D., et al. Effects of millet whole grain supplementation on the lipid profile and gut bacteria in rats fed with high-fat diet. Journal of Functional Foods. 2019;59:49–59.
Loman B.R., Hernández-Saavedra D., An R., Rector R.S. Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis. Nutrition Reviews. 2018;76(11):822–839. PubMed
López-Castejón M.L., et al. Characterization of prebiotic emulsions stabilized by inulin and β-lactoglobulin. Food Hydrocolloids. 2019;87:382–393.
Luoto R., Ruuskanen O., Waris M., Kalliomäki M., Salminen S., Isolauri E. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial. The Journal of Allergy and Clinical Immunology. 2014;133(2):405–413. PubMed PMC
Mackie A., Bajka B., Rigby N. Roles for dietary fibre in the upper GI tract: The importance of viscosity. Food Research International. 2016;88:234–238.
Makki K., Deehan E.C., Walter J., Bäckhed F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host & Microbe. 2018;23(6):705–715. PubMed
Mariat D., Firmesse O., Levenez F., Guimarăes V., Sokol H., Doré J., et al. The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiology. 2009;9(1):123. PubMed PMC
Marino M., et al. Viability of probiotic Lactobacillus rhamnosus in structured emulsions containing saturated monoglycerides. Journal of Functional Foods. 2017;35:51–59.
Martínez I., Lattimer J.M., Hubach K.L., Case J.A., Yang J., Weber C.G., et al. Gut microbiome composition is linked to whole grain-induced immunological improvements. The ISME Journal. 2013;7(2):269–280. PubMed PMC
McCarty M.F., Assanga S.B.I. Ferulic acid may target MyD88-mediated pro-inflammatory signaling–Implications for the health protection afforded by whole grains, anthocyanins, and coffee. Medical Hypotheses. 2018;118:114–120. PubMed
Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Mahony J., et al. The first microbial colonizers of the human gut: Composition, activities, and health implications of the infant gut microbiota. Microbiology and Molecular Biology Reviews : Microbiology and Molecular Biology Reviews. 2017;81(4) doi: 10.1128/MMBR.00036-17. e00036-00017. PubMed DOI PMC
Miraghajani M., et al. The impact of probiotic soy milk consumption on oxidative stress among type 2 diabetic kidney disease patients: A randomized controlled clinical trial. Journal of Renal Nutrition. 2017;27(5):317–324. PubMed
Mitra D., Jena A.K., De A., Das M., Das B., Samanta A. Prebiotic potential of gum odina and its impact on gut ecology: In vitro and in vivo assessments. Food and Function. 2016;7(7):3064–3072. PubMed
Moen B., Henjum K., Måge I., Knutsen S.H., Rud I., Hetland R.B., et al. Effect of dietary fibers on cecal microbiota and intestinal tumorigenesis in azoxymethane treated A/J Min/+ mice. PLoS One. 2016;11(5) PubMed PMC
Müller M., Canfora E.E., Blaak E.E. Gastrointestinal transit time, glucose homeostasis and metabolic health: Modulation by dietary fibers. Nutrients. 2018;10(3):275. PubMed PMC
Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R.…Tschöp M.H. Glucagon-like peptide 1 (GLP-1) Molecular Metabolism. 2019;30:72–130. doi: 10.1016/j.molmet.2019.09.010. PubMed DOI PMC
Murugesan S., Nirmalkar K., Hoyo-Vadillo C., García-Espitia M., Ramírez-Sánchez D., García-Mena J. Gut microbiome production of short-chain fatty acids and obesity in children. European Journal of Clinical Microbiology & Infectious Diseases. 2018;37(4):621–625. PubMed
Nicolucci A.C., et al. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711–722. PubMed
Nourbehesht N., et al. Investigation of stability, consistency, and oil oxidation of emulsion filled gel prepared by inulin and rice bran oil using ultrasonic radiation. Ultrasonics Sonochemistry. 2018;42:585–593. PubMed
O'Keefe S.J.D. The need to reassess dietary fiber requirements in healthy and critically ill patients. Gastroenterology Clinics of North America. 2018;47(1):219–229. doi: 10.1016/j.gtc.2017.10.005. PubMed DOI PMC
O'Keefe S.J., Li J.V., Lahti L., Ou J., Carbonero F., Mohammed K.…Zoetendal E.G. Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications. 2015;6:6342. doi: 10.1038/ncomms7342. PubMed DOI PMC
Olaya Galan N., Ulloa Rubiano J., Velez Reyes F., Fernandez Duarte K., Salas Cardenas S., Gutierrez Fernandez M. In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP 4 protein production. Journal of Applied Microbiology. 2016;120(4):1041–1051. PubMed
Paradiso V.M., et al. Production and characterization of emulsion filled gels based on inulin and extra virgin olive oil. Food Hydrocolloids. 2015;45:30–40.
Peredo A., Beristain C., Pascual L., Azuara E., Jimenez M. The effect of prebiotics on the viability of encapsulated probiotic bacteria. Lebensmittel-Wissenschaft & Technologie. 2016;73:191–196.
Pinto-Sanchez M.I., et al. Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with irritable bowel syndrome. Gastroenterology. 2017;153(2):448–459. e448. PubMed
Pinto S.S., et al. Potential use of whey concentrate and prebiotics as carrier agents to protect Bifidobacterium-BB-12 microencapsulated by spray drying. Food Research International. 2015;67:400–408.
Poletto G., et al. Encapsulation of Lactobacillus acidophilus and different prebiotic agents by external ionic gelation followed by freeze-drying. Ciência Rural. 2019;49(2)
Prasad K.N., Bondy S.C. Dietary fibers and their fermented short-chain fatty acids in prevention of human diseases. Bioactive Carbohydrates and Dietary Fibre. 2019;17 PubMed
Qi W., et al. Growth and survival of microencapsulated probiotics prepared by emulsion and internal gelation. Journal of Food Science and Technology. 2019;56(3):1398–1404. PubMed PMC
Raddatz G.C., et al. Use of prebiotic sources to increase probiotic viability in pectin microparticles obtained by emulsification/internal gelation followed by freeze-drying. Food Research International. 2020;130 PubMed
Reynolds A.N., Akerman A.P., Mann J. Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses. PLoS Medicine. 2020;17(3) PubMed PMC
Rigo-Adrover M.d.M., Knipping K., Garssen J., van Limpt K., Knol J., Franch À., et al. Prevention of rotavirus diarrhea in suckling rats by a specific fermented milk concentrate with prebiotic mixture. Nutrients. 2019;11(1):189. PubMed PMC
Roager H.M., Vogt J.K., Kristensen M., Hansen L.B.S., Ibrügger S., Mærkedahl R.B., et al. Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: A randomised cross-over trial. Gut. 2019;68(1):83–93. PubMed PMC
Rodríguez J.M., Murphy K., Stanton C., Ross R.P., Kober O.I., Juge N., et al. The composition of the gut microbiota throughout life, with an emphasis on early life. Microbial Ecology in Health and Disease. 2015;26 doi: 10.3402/mehd.v26.26050. 26050-26050. PubMed DOI PMC
Roshanravan N., et al. The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial. Journal of Cardiovascular and Thoracic Research. 2017;9(4):183. PubMed PMC
Russell W.R., Gratz S.W., Duncan S.H., Holtrop G., Ince J., Scobbie L., et al. High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health. American Journal of Clinical Nutrition. 2011;93(5):1062–1072. PubMed
Sepideh A., et al. Effects of multistrain probiotic supplementation on glycemic and inflammatory indices in patients with nonalcoholic fatty liver disease: A double-blind randomized clinical trial. Journal of the American College of Nutrition. 2016;35(6):500–505. PubMed
Serrano-Casas V., et al. Improvement of lactic acid bacteria viability in acid conditions employing agroindustrial co-products as prebiotic on alginate ionotropic gel matrix co-encapsulation. Journal of Functional Foods. 2017;38:293–297.
Shadnoush M., et al. Effects of probiotics on gut microbiota in patients with inflammatory bowel disease: A double-blind, placebo-controlled clinical trial. Korean Journal of Gastroenterology. 2015;65(4):215–221. PubMed
Shah B.R., Li B., Wang L., Liu S., Li Y., Wei X., et al. Health benefits of konjac glucomannan with special focus on diabetes. Bioactive Carbohydrates and Dietary Fibre. 2015;5(2):179–187.
Silva E.K., et al. Biopolymer-prebiotic carbohydrate blends and their effects on the retention of bioactive compounds and maintenance of antioxidant activity. Carbohydrate Polymers. 2016;144:149–158. PubMed
Silva E.K., Guimarães J.T., Costa A.L.R., Cruz A.G., Meireles M.A.A. Non-thermal processing of inulin-enriched soursop whey beverage using supercritical carbon dioxide technology. The Journal of Supercritical Fluids. 2019;154
Sivaprakasam S., Gurav A., Paschall A., Coe G., Chaudhary K., Cai Y.…Huang L. An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis. Oncogenesis. 2016;5(6) e238-e238. PubMed PMC
Slavin J. Fiber and prebiotics: Mechanisms and health benefits. Nutrients. 2013;5(4):1417–1435. PubMed PMC
Soldi S., Vasileiadis S., Lohner S., Uggeri F., Puglisi E., Molinari P., et al. Prebiotic supplementation over a cold season and during antibiotic treatment specifically modulates the gut microbiota composition of 3-6 year-old children. Beneficial Microbes. 2019;10(3):253–263. PubMed
Soleimani A., et al. Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. Kidney International. 2017;91(2):435–442. PubMed
Soliman G.A. Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients. 2019;11(5):1155. PubMed PMC
Song E.-J., et al. Effect of probiotics on obesity-related markers per enterotype: A double-blind, placebo-controlled, randomized clinical trial. The EPMA Journal. 2020;11(1):31–51. PubMed PMC
Souza M.W.S.d., et al. Effect of inulin, medium-chain triglycerides and whey protein isolate on stability and in vitro digestibility of enteral nutrition formulas. Food Science and Technology. 2019 doi: 10.1590/fst.23619. ((AHEAD)) DOI
Taha-Abdelaziz K., Astill J., Kulkarni R.R., Read L.R., Najarian A., Farber J.M., et al. In vitro assessment of immunomodulatory and anti-Campylobacter activities of probiotic lactobacilli. Scientific Reports. 2019;9(1):1–15. PubMed PMC
Tajabadi-Ebrahimi M., et al. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Experimental and Clinical Endocrinology & Diabetes. 2017;125:21–27. 01. PubMed
Threapleton D.E., Greenwood D.C., Evans C.E., Cleghorn C.L., Nykjaer C., Woodhead C.…Burley V.J. Dietary fibre intake and risk of cardiovascular disease: Systematic review and meta-analysis. BMJ. 2013;347:f6879. PubMed PMC
Tojo R., Suárez A., Clemente M.G., de los Reyes-Gavilán C.G., Margolles A., Gueimonde M., et al. Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis. World Journal of Gastroenterology: WJG. 2014;20(41) PubMed PMC
Trakooncharoenvit A., Tanaka S., Mizuta E., Hira T., Hara H. Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats. European Journal of Nutrition. 2019:1–10. PubMed
Um C.Y., Campbell P.T., Carter B., Wang Y., Gapstur S.M., McCullough M.L. Association between grains, gluten and the risk of colorectal cancer in the cancer prevention study-II nutrition cohort. European Journal of Nutrition. 2019:1–11. PubMed
Vaghef-Mehrabany E., et al. Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: A randomized double-blind clinical trial. Journal of the American College of Nutrition. 2016;35(4):291–299. PubMed
Vanegas S.M., Meydani M., Barnett J.B., Goldin B., Kane A., Rasmussen H.…Jonnalagadda S. Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults. American Journal of Clinical Nutrition. 2017;105(3):635–650. PubMed PMC
Venegas D.P., Marjorie K., Landskron G., González M.J., Quera R., Dijkstra G.…Hermoso M.A. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology. 2019;10 PubMed PMC
Wang Y., et al. Prebiotic carbohydrates: Effect on physicochemical stability and solubility of algal oil nanoparticles. Carbohydrate Polymers. 2020;228 PubMed
Wang W., Li J., Chen X., Yu M., Pan Q., Guo L. Whole grain food diet slightly reduces cardiovascular risks in obese/overweight adults: A systematic review and meta-analysis. BMC Cardiovascular Disorders. 2020;20(1):1–11. PubMed PMC
Wells J.M. Paper presented at the Microbial cell factories. 2011. Immunomodulatory mechanisms of lactobacilli. PubMed PMC
Wu W.-C., Inui A., Chen C.-Y. Weight loss induced by whole grain-rich diet is through a gut microbiota-independent mechanism. World Journal of Diabetes. 2020;11(2):26. PubMed PMC
Xu J., Chen D., Liu C., Wu X.-Z., Dong C.-X., Zhou J. Structural characterization and anti-tumor effects of an inulin-type fructan from Atractylodes chinensis. International Journal of Biological Macromolecules. 2016;82:765–771. PubMed
Xu W., et al. Stability, microstructural and rheological properties of complex prebiotic emulsion stabilized by sodium caseinate with inulin and konjac glucomannan. Food Hydrocolloids. 2020;105
Xu W., Huang K., Jin W., Luo D., Liu H., Li Y., et al. Catalytic and anti-bacterial properties of biosynthesized silver nanoparticles using native inulin. RSC Advances. 2018;8(50):28746–28752. PubMed PMC
Xu Y., Wan Q., Feng J., Du L., Li K., Zhou Y. Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized trials. Medicine. 2018;97(43) PubMed PMC
Xu Y., Yang J., Du L., Li K., Zhou Y. Association of whole grain, refined grain, and cereal consumption with gastric cancer risk: A meta‐analysis of observational studies. Food Science and Nutrition. 2019;7(1):256–265. PubMed PMC
Yang Y., Song H., Wang L., Dong W., Yang Z., Yuan P., et al. Antiviral effects of a probiotic metabolic products against transmissible gastroenteritis coronavirus. Journal of Problem Health. 2017;5(3):1–6.
Yen C., Tate J.E., Hyde T.B., Cortese M.M., Lopman B.A., Jiang B.…Parashar U.D. Rotavirus vaccines: Current status and future considerations. Human Vaccines & Immunotherapeutics. 2014;10(6):1436–1448. PubMed PMC
Yoo J.Y., Kim S.S. Probiotics and prebiotics: Present status and future perspectives on metabolic disorders. Nutrients. 2016;8(3):173. PubMed PMC
Yoon H., et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Biochemistry and Nutrition. 2015;57(2):129–134. doi: 10.3164/jcbn.15-14. 15-14. PubMed DOI PMC
Zabot G.L., et al. Replacing modified starch by inulin as prebiotic encapsulant matrix of lipophilic bioactive compounds. Food Research International. 2016;85:26–35. PubMed
Zamani B., et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled trial. International Journal of Rheumatic Diseases. 2016;19(9):869–879. PubMed
Zhang Y., et al. The increased viability of probiotic Lactobacillus salivarius NRRL B-30514 encapsulated in emulsions with multiple lipid-protein-pectin layers. Food Research International. 2015;71:9–15.
Zhang Y., et al. S/O/W emulsions prepared with sugar beet pectin to enhance the viability of probiotic Lactobacillus salivarius NRRL B-30514. Food Hydrocolloids. 2016;52:804–810.
Zhang T., Li Q., Cheng L., Buch H., Zhang F. Akkermansia muciniphila is a promising probiotic. Microbial Biotechnology. 2019;12(6):1109–1125. doi: 10.1111/1751-7915.13410. PubMed DOI PMC
Zhao M., et al. Probiotic encapsulation in water-in-water emulsion via heteroprotein complex coacervation of type-A gelatin/sodium caseinate. Food Hydrocolloids. 2020;105
Zhao L., Zhang F., Ding X., Wu G., Lam Y.Y., Wang X.…Ma J. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018;359(6380):1151–1156. PubMed
Zhu C., Sawrey-Kubicek L., Beals E., Rhodes C.H., Houts H.E., Sacchi R., et al. Human gut microbiome composition and tryptophan metabolites were changed differently by fast food and mediterranean diet in four days: A pilot study. Nutrition Research. May 2020;77:62–72. doi: 10.1016/j.nutres.2020.03.005. PubMed DOI