Special Issue: Animal Modeling in Cancer
Language English Country Switzerland Media electronic
Document type Editorial, Research Support, Non-U.S. Gov't
PubMed
32867303
PubMed Central
PMC7564229
DOI
10.3390/genes11091009
PII: genes11091009
Knihovny.cz E-resources
- Keywords
- cancer, gene editing, hematologic malignancies, mouse models, non-mouse models, solid tumors, stem cells,
- MeSH
- Biomedical Research * MeSH
- Humans MeSH
- Disease Models, Animal * MeSH
- Neoplasms genetics metabolism pathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Editorial MeSH
Recent advances in high-throughput sequencing techniques have significantly accelerated the development of personalized diagnostic tools and cancer treatments. However, a comparative analysis of experimental animals that share similar genetic, physiological, and behavioral traits with humans remains the basis for understanding the pathological mechanisms associated with human diseases, including cancer. The generation and characterization of suitable animal models mimicking tumor growth and progression thus represents an important "component" of tumor biology research. The presented Special Issue contains ten review articles, which, based on data obtained from various animal models, summarize a number of aspects of the tumor formation process that include gastrointestinal neoplasia, breast cancer, hematological malignancies, melanoma, and brain tumors. This Special Issue nicely illustrates how the study of suitable living models uncovers not only the fundamental molecular and cellular bases of neoplastic growth, but might also indicate approaches to efficient cancer treatments.
See more in PubMed
Lanikova L., Babosova O., Prchal J.T. Experimental modeling of myeloproliferative neoplasms. Genes (Basel) 2019;10:813. doi: 10.3390/genes10100813. PubMed DOI PMC
Skayneh H., Jishi B., Hleihel R., Hamieh M., Darwiche N., Bazarbachi A., El Sabban M., El Hajj H. A critical review of animal models used in acute myeloid leukemia pathophysiology. Genes (Basel) 2019;10:614. doi: 10.3390/genes10080614. PubMed DOI PMC
Hason M., Bartunek P. Zebrafish models of cancer-new insights on modeling human cancer in a non-mammalian vertebrate. Genes (Basel) 2019;10:935. doi: 10.3390/genes10110935. PubMed DOI PMC
Stastna M., Janeckova L., Hrckulak D., Kriz V., Korinek V. Human colorectal cancer from the perspective of mouse models. Genes (Basel) 2019;10:788. doi: 10.3390/genes10100788. PubMed DOI PMC
Leystra A.A., Clapper M.L. Gut microbiota influences experimental outcomes in mouse models of colorectal cancer. Genes (Basel) 2019;10:900. doi: 10.3390/genes10110900. PubMed DOI PMC
Chawengsaksophak K. Cdx2 animal models reveal developmental origins of cancers. Genes (Basel) 2019;10:928. doi: 10.3390/genes10110928. PubMed DOI PMC
Horak V., Palanova A., Cizkova J., Miltrova V., Vodicka P., Skalníková H.K. Melanoma-bearing libechov minipig (melim): The unique swine model of hereditary metastatic melanoma. Genes (Basel) 2019;10:915. doi: 10.3390/genes10110915. PubMed DOI PMC
Baloghova N., Lidak T., Cermak L. Ubiquitin ligases involved in the regulation of wnt, tgf-beta, and notch signaling pathways and their roles in mouse development and homeostasis. Genes (Basel) 2019;10:815. doi: 10.3390/genes10100815. PubMed DOI PMC
Moorehead R.A. Rodent models assessing mammary tumor prevention by soy or soy isoflavones. Genes (Basel) 2019;10:566. doi: 10.3390/genes10080566. PubMed DOI PMC
Michaelidesova A., Konirova J., Bartunek P., Zikova M. Effects of radiation therapy on neural stem cells. Genes (Basel) 2019;10:640. doi: 10.3390/genes10090640. PubMed DOI PMC
