Mild and Selective Method of Bromination of Flavonoids
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Flavonoids chemistry MeSH
- Halogenation * MeSH
- Spectrometry, Mass, Electrospray Ionization methods MeSH
- Molecular Structure MeSH
- Oxidation-Reduction MeSH
- Silymarin chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Flavonoids MeSH
- Silymarin MeSH
A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
References provided by Crossref.org
Selectively Halogenated Flavonolignans-Preparation and Antibacterial Activity
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
