A multifaceted study involving focused ion beam scanning electron microscopy techniques, mechanical analysis, water adsorption measurements, and molecular simulations is employed to rationalize the nitric oxide release performance of polyurethane films containing 5, 10, 20, and 40 wt % of the metal-organic framework (MOF) CPO-27-Ni. The polymer and the MOF are first demonstrated to exhibit excellent compatibility. This is reflected in the even distribution and encapsulation of large wt % MOF loadings throughout the full thickness of the films and by the rather minimal influence of the MOF on the mechanical properties of the polymer at low wt %. The NO release efficiency of the MOF is attenuated by the polymer and found to depend on wt % of MOF loading. The formation of a fully connected network of MOF agglomerates within the films at higher wt % is proposed to contribute to a more complex guest transport in these formulations, resulting in a reduction of NO release efficiency and film ductility. An optimum MOF loading of 10 wt % is identified for maximizing NO release without adversely impacting the polymer properties. Bactericidal efficacy of released NO from the films is demonstrated against Pseudomonas aeruginosa, with a >8 log10 reduction in cell density observed after a contact period of 24 h.

Defence Science and Technology Laboratory Porton Down Salisbury Wiltshire SP4 0JQ U K

Department of Engineering Science University of Oxford Parks Road Oxford OX1 3PJ U K

Department of Physical and Macromolecular Chemistry Faculty of Sciences Charles University Hlavova 8 128 43 Prague 2 Czech Republic

ICGM Université de Montpellier CNRS ENSCM Montpellier 75005 France

School of Chemistry University of St Andrews Purdie Building St Andrews KY16 9ST U K

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Controlled Synthesis of Large Single Crystals of Metal-Organic Framework CPO-27-Ni Prepared by a Modulation Approach: In situ Single-Crystal X-ray Diffraction Studies