Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
33340625
DOI
10.1016/j.ijbiomac.2020.12.107
PII: S0141-8130(20)35274-0
Knihovny.cz E-resources
- Keywords
- Drug carrier, Inflammation, Monocytes, Natural compounds, Pharmaceutical composite, β-glucan microparticles,
- MeSH
- Anti-Inflammatory Agents pharmacology MeSH
- Antioxidants pharmacology MeSH
- Artemisinins pharmacology MeSH
- Cytokines MeSH
- Flavonoids chemistry pharmacology MeSH
- Glucans chemistry pharmacology MeSH
- Catechin analogs & derivatives chemistry pharmacology MeSH
- Ellagic Acid chemistry pharmacology MeSH
- Monocytes drug effects MeSH
- NF-kappa B MeSH
- Resveratrol chemistry pharmacology MeSH
- Saccharomyces cerevisiae Proteins MeSH
- Saccharomyces cerevisiae MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Antioxidants MeSH
- artemisinin MeSH Browser
- Artemisinins MeSH
- Cytokines MeSH
- epigallocatechin gallate MeSH Browser
- Flavonoids MeSH
- Glucans MeSH
- Catechin MeSH
- Ellagic Acid MeSH
- morusin MeSH Browser
- NF-kappa B MeSH
- Resveratrol MeSH
- Saccharomyces cerevisiae Proteins MeSH
Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
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