• This record comes from PubMed

Identification of novel genetic loci for risk of multiple myeloma by functional annotation

. 2023 Nov ; 37 (11) : 2326-2329. [epub] 20230918

Language English Country Great Britain, England Media print-electronic

Document type Letter, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural

Grant support
P50 CA186781 NCI NIH HHS - United States
U01 CA271014 NCI NIH HHS - United States
U01 CA249955 NCI NIH HHS - United States

Links

PubMed 37723249
PubMed Central PMC10624610
DOI 10.1038/s41375-023-02022-8
PII: 10.1038/s41375-023-02022-8
Knihovny.cz E-resources

Alfred Sokolowski Specialist Hospital in Walbrzych Oncology Support Centre for Clinical Trials Wałbrzych Poland

Biomedical Center Faculty of Medicine Charles University Pilsen Pilsen Czech Republic

Cancer Control Research BC Cancer Vancouver BC Canada

Cancer Epidemiology Division Cancer Council Victoria Melbourne VIC Australia

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria

Centre for Epidemiology and Biostatistics School of Population and Global Health The University of Melbourne Melbourne VIC Australia

Centre for Individualised Infection Medicine Hannover Germany

Department for Immunology and Metabolism Life and Medical Sciences Institute University of Bonn Bonn Germany

Department of Biochemistry and Molecular Biology 1 University of Granada Granada Spain

Department of Biology University of Pisa Pisa Italy

Department of Clinical Immunology the Bloodbank Rigshospitalet Copenhagen University Hospital København Denmark

Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia SC USA

Department of Experimental Hematooncology Medical University of Lublin Lublin Poland

Department of Haematology and Transplantology Medical University of Gdańsk Gdańsk Poland

Department of Hematology Holycross Cancer Center Kielce Poland

Department of Hematology Institute of Hematology and Transfusion Medicine Warsaw Poland

Department of Hematology Provincial Polyclinical Hospital in Torun Torun Poland

Department of Hematology Rydygier Specialistic Hospital Cracow Poland

Department of Hematology Semmelweis University Budapest Hungary

Department of Hematology Specialist Hospital No 1 in Bytom Academy of Silesia Faculty of Medicine Katowice Poland

Department of Hematology Transplantology and Internal Medicine Medical University of Warsaw Warsaw Poland

Department of Hematology University Hospital Crakow Poland

Department of Hematology University Hospital No 2 in Bydgoszcz Bydgoszcz Poland

Department of Hematology Warmian Masurian Cancer Center of The Ministry Of The Interior And Administration's Hospital Olsztyn Poland

Department of Internal Medicine 5 Heidelberg University Hospital Heidelberg Germany

Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center Nijmegen The Netherlands

Department of Lymphoma Myeloma Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston TX USA

Department of Lymphoproliferative Diseases Maria Skłodowska Curie National Research Institute of Oncology Warsaw Poland

Department of Medicine University of California San Francisco Helen Diller Family Comprehensive Cancer Center San Francisco CA USA

Department of Pathology School of Medicine at the University of Alabama Birmingham AL USA

Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic Rochester MN USA

Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA

Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany

Division of Epidemiology Department of Health Sciences Research Mayo Clinic Rochester MN USA

Division of Hematology and Huntsman Cancer Institute University of Utah Salt Lake City UT USA

Division of Hematology Department of Internal Medicine Mayo Clinic Rochester MN USA

Division of Hematology Oncology Division of Hematology Oncology Department of Medicine School of Medicine Department of Pathology School of Medicine Susan and Henry Samueli College of Health Sciences Chao Family Comprehensive Cancer Center University of California at Irvine Irvine CA USA

Division of Pediatric Neurooncology German Cancer Research Center Heidelberg Germany

Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany

Genomic Oncology Area GENYO Centre for Genomics and Oncological Research Pfizer University of Granada Andalusian Regional Government PTS Granada Spain

Hematology and Medical Oncology Department University Hospital Morales Meseguer IMIB Murcia Spain

Hematology Department Jagiellonian University Medical College Cracow Poland

Hematology Department Virgen de las Nieves University Hospital Granada Spain

Hematology Division Chaim Sheba Medical Center Tel Hashomer Israel

Hematology Unit Department of Clinical and Experimental Medicine University of Pisa Pisa Italy

Hopp Children's Cancer Center Heidelberg Germany

Hospital Universitario 12 de Octubre Instituto de Investigación del Hospital Universitario 12 de Octubre 28041 Madrid Spain

ICVS 3B's PT Government Associate Laboratory Braga Guimarães Portugal

INSERM 1052 CNRS 5286 CRCL Lyon France

Institute of Medical Sciences College of Medical Sciences University of Rzeszow Rzeszow Poland

Institute of Molecular Medicine University of Southern Denmark Odense Denmark

Institute of Regional Research University of Southern Denmark Odense Denmark

Instituto de Investigación Biosanitaria IBs Granada Granada Spain

Life and Health Sciences Research Institute School of Health Sciences University of Minho Braga Portugal

Molecular Diagnostics and Clinical Research Unit Institute of Regional Health Research University Hospital of Southern Denmark Odense Denmark

National Centre for Tumour Diseases University Hospital Heidelberg Heidelberg Germany

National Centre for Tumour Diseases University Hospital Heidelberg Heidelberg Germany GMMG Study Group at University Hospital Heidelberg Heidelberg Germany

National Research Centre for the Working Environment Copenhagen Denmark

Precision Medicine School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia

Program in Epidemiology Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA

St John's Hospital Budapest Hungary

U O Dipartimento di Ematologia Azienda USL Toscana Nord Ovest Livorno Italy

University Hospital of Salamanca Diagnostic Laboratory Unit in Hematology University Hospital of Salamanca IBSAL CIBERONC Centro de Investigación del Cáncer IBMCC Salamanca Spain

Wroclaw Medical University Wroclaw Poland

See more in PubMed

Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, et al. Multiple myeloma. Nat Rev Dis Prim. 2017;3:17046. doi: 10.1038/nrdp.2017.46. PubMed DOI

Georgakopoulou R, Fiste O, Sergentanis TN, Andrikopoulou A, Zagouri F, Gavriatopoulou M, et al. Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses. J Clin Med. 2021;10:4179. doi: 10.3390/jcm10184179. PubMed DOI PMC

Kristinsson SY, Bjorkholm M, Goldin LR, Blimark C, Mellqvist UH, Wahlin A, et al. Familial Aggregation of Multiple Myeloma and Its Precursor Monoclonal Gammopathy of Undetermined Significance (MGUS): A Population-Based Study in Sweden. Blood. 2008;112:1678. doi: 10.1182/blood.V112.11.1678.1678. DOI

Pertesi M, Went M, Hansson M, Hemminki K, Houlston RS, Nilsson B. Genetic predisposition for multiple myeloma. Leukemia. 2020;34:697–708. doi: 10.1038/s41375-019-0703-6. PubMed DOI

Campa D, Gentiluomo M, Stein A, Aoki MN, Oliverius M, Vodičková L, et al. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer. Crit Rev Oncol Hematol. 2023;186:104020. doi: 10.1016/j.critrevonc.2023.104020. PubMed DOI

Yu Y, Mao L, Cheng Z, Zhu X, Cui J, Fu X, et al. A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study. Arch Toxicol. 2021;95:3815–27. doi: 10.1007/s00204-021-03170-5. PubMed DOI

Iversen ES, Lipton G, Clyde MA, Monteiro ANA. Functional annotation signatures of disease susceptibility loci improve SNP association analysis. BMC Genom. 2014;15:398. doi: 10.1186/1471-2164-15-398. PubMed DOI PMC

Liu W, Li M, Zhang W, Zhou G, Wu X, Wang J, et al. Leveraging functional annotation to identify genes associated with complex diseases. PLOS Comput Biol. 2020;16:e1008315. doi: 10.1371/journal.pcbi.1008315. PubMed DOI PMC

Kim PKM, Armstrong M, Liu Y, Yan P, Bucher B, Zuckerbraun BS, et al. IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo. Oncogene. 2004;23:1125–35. doi: 10.1038/sj.onc.1207023. PubMed DOI

Armstrong MJ, Stang MT, Liu Y, Gao J, Ren B, Zuckerbraun BS, et al. Interferon Regulatory Factor 1 (IRF-1) induces p21WAF1/CIP1 dependent cell cycle arrest and p21WAF1/CIP1 independent modulation of survivin in cancer cells. Cancer Lett. 2012;319:56–65. doi: 10.1016/j.canlet.2011.12.027. PubMed DOI PMC

Segueni J, Noordermeer D. CTCF: A misguided jack-of-all-trades in cancer cells. Comput Struct Biotechnol J. 2022;20:2685–98. doi: 10.1016/j.csbj.2022.05.044. PubMed DOI PMC

Walter SA, Cutler RE, Martinez R, Gishizky M, Hill RJ. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. J Biol Chem. 2003;278:18221–8. doi: 10.1074/jbc.M212556200. PubMed DOI

Bi L, Jia S, Hu W, Su X, Chen X, Tang H. Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia. BMC Med Genom. 2022;15:101. doi: 10.1186/s12920-022-01251-7. PubMed DOI PMC

Zhang L, Lu SY, Guo R, Ma JX, Tang LY, Wang JJ, et al. STK10 knockout inhibits cell migration and promotes cell proliferation via modulating the activity of ERM and p38 MAPK in prostate cancer cells. Exp Ther Med. 2021;22:851. doi: 10.3892/etm.2021.10283. PubMed DOI PMC

Burger R. Impact of Interleukin-6 in Hematological Malignancies. TMH. 2013;40:336–43. PubMed PMC

Harmer D, Falank C, Reagan MR. Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma. Front Endocrinol. 2019;9:788. doi: 10.3389/fendo.2018.00788. PubMed DOI PMC

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...