Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

1st Department of Propaedeutic Surgery Hippocration General Hospital National and Kapodistrian University of Athens Athens Greece

ARC Net Research Center Department of Diagnostics and Public Health University and Hospital Trust of Verona Verona Italy

Azienda Ospedale Università di Padova Medicina di Laboratorio Padova Italy

Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic

Center for Experimental and Molecular Medicine Laboratory of Experimental Oncology and Radiobiology Amsterdam UMC location University of Amsterdam Amsterdam the Netherlands; Oncode Institute Amsterdam the Netherlands; Imaging and Biomarkers Cancer Center Amsterdam Amsterdam the Netherlands

Center for Translational Medicine Semmelweis University Budapest Hungary; Carol Davila University of Medicine and Pharmacy Bucharest Romania; Center for Digestive Diseases and Liver Transplant Fundeni Clinical Insitute Bucharest Romania

Center for Translational Research in Oncology São Paulo Brazil

Department of Diagnostics and Public Health Section of Pathology University and Hospital Trust of Verona Verona Italy

Department of General Visceral and Thoracic Surgery University Medical Center Hamburg Eppendorf Hamburg Germany

Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany

Department of Hematology Transplantation and Internal Medicine Medical University of Warsaw Warsaw Poland

Department of Molecular Biology of Cancer Institute of Experimental Medicine of the Czech Academy of Sciences Prague Czech Republic; Institute of Biology and Medical Genetics 1st Faculty of Medicine Charles University and General University Hospital Prague Prague Czech Republic

Department of Molecular Biology of Cancer Institute of Experimental Medicine of the Czech Academy of Sciences Prague Czech Republic; Institute of Biology and Medical Genetics 1st Faculty of Medicine Charles University and General University Hospital Prague Prague Czech Republic; Biomedical Centre Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic

Department of Oncology Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic

Department of Oncology Fondazione IRCCS Casa Sollievo della Sofferenza Hospital San Giovanni Rotondo Italy

Department of Pulmonary diseases Erasmus MC University Medical Center Rotterdam the Netherlands

Department of Surgery 1 University Hospital Olomouc Olomouc Czech Republic

Department of Surgery Erasmus MC University Medical Center Rotterdam the Netherlands

Department of Surgery The Pancreas Institute University and Hospital Trust of Verona Verona Italy

Department of Surgery University Hospital Brno Faculty of Medicine Masaryk University Brno Czech Republic; Department of Gastroenterology and Digestive Endoscopy Masaryk Memorial Cancer Institute Brno Czech Republic; 2nd Department of Internal Medicine Gastroenterology and Geriatrics University Hospital Olomouc Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic

Department of Surgery University Hospital Kralovske Vinohrady 3rd Faculty of Medicine Charles University Prague Czech Republic

Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy

Departments of Oncology and Medicine Copenhagen University Hospital Herlev Denmark

Dept of Digestive Tract Diseases Medical University of Lodz Lodz Poland

Dept of Medicine University of Padova Medicina di Laboratorio Padova Italy

Dept of Surgery Oncology and Gastroenterology University of Padova Chirurgia Generale 1 Padova Italy

Dept of Surgery Oncology and Gastroenterology University of Padova Chirurgia Generale 3 Padova Italy

Division of Cancer Epidemiology C020 German Cancer Research Center Heidelberg Germany

Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany

Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany; Saarland Cancer Registry Saarbrücken Germany

Division of Gastroenterology and Research Laboratory Fondazione IRCCS Casa Sollievo della Sofferenza Hospital San Giovanni Rotondo Italy

Division of General and Transplant Surgery Pisa University Hospital Pisa Italy

Endoscopic Unit Department of Gastroenterology IRCCS Humanitas Research Hospital Milan Italy

Gastroenterology and Gastrointestinal Endoscopy Unit Vita Salute San Raffaele University IRCCS San Raffaele Scientific Institute Milan Italy

General Surgery Unit Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy

Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany

Genomic Oncology Area GENYO Centre for Genomics and Oncological Research Pfizer University of Granada Andalusian Regional Government Granada Spain; Instituto de Investigación Biosanitaria de Granada Complejo Hospitales Universitarios de Granada Universidad de Granada Granada Spain; Department of Immunology University of Granada Granada Spain

Imaging and Biomarkers Cancer Center Amsterdam Amsterdam the Netherlands; Department of Pathology Amsterdam UMC location University of Amsterdam Amsterdam the Netherlands

Institute for Digestive Research and Gastroenterology Department Lithuanian University of Health Sciences Kaunas Lithuania

Institute for Translational Medicine Medical School University of Pécs Pécs Hungary

Institute of Pancreatic Diseases Semmelweis University Budapest Hungary; Center for Translational Medicine Semmelweis University Budapest Hungary

Institute of Pancreatic Diseases Semmelweis University Budapest Hungary; Center for Translational Medicine Semmelweis University Budapest Hungary; Institute for Translational Medicine Medical School University of Pécs Pécs Hungary

Institute of Pancreatic Diseases Semmelweis University Budapest Hungary; Center for Translational Medicine Semmelweis University Budapest Hungary; Institute for Translational Medicine Medical School University of Pécs Pécs Hungary; Translational Pancreatology Research Group Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged Szeged Hungary

Instituto BIFI Universidad de Zaragoza Zaragoza Spain

Laboratory for Applied Science and Technology in Health Carlos Chagas Institute Oswaldo Cruz Foundation Curitiba Brazil

Laboratory of Biology Department of Basic Medical Sciences Medical School National and Kapodistrian University of Athens Athens Greece

Liverpool Experimental Cancer Medicine Centre University of Liverpool Liverpool United Kingdom

Meyer Children's Hospital IRCCS Florence Italy

Oncological Department Massa Carrara Azienda USL Toscana Nord Ovest Carrara Italy

Pancreatic Unit IRCCS Humanitas Research Hospital Milan Italy; Department of Biomedical Sciences Humanitas University Milan Italy

Pancreato Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center IRCCS San Raffaele Scientic Institute Milan Italy

Pancreato Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center San Raffaele Scientific Institute Istituto di Ricovero e Cura a Carattere Scientifico Milan Italy; Digestive and Liver Disease Unit Sant' Andrea Hospital Rome Italy

Potenza Medica County Association Potenza Italy

Unit of Genetic Department of Biology University of Pisa Pisa Italy

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