Mitogenomics of the endemic Ethiopian rats: looking for footprints of adaptive evolution in sky islands
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
33412336
DOI
10.1016/j.mito.2020.12.015
PII: S1567-7249(20)30246-4
Knihovny.cz E-resources
- Keywords
- Adaptation, Adaptive introgression, NADH dehydrogenase, Oxidative phosphorylation, Positive selection, dN/dS,
- MeSH
- Phylogeny MeSH
- Genetic Introgression MeSH
- Mitochondrial Proteins chemistry genetics MeSH
- Mitochondria genetics MeSH
- Evolution, Molecular MeSH
- Models, Molecular MeSH
- Murinae classification genetics MeSH
- Oxidative Phosphorylation MeSH
- Sequence Analysis, DNA methods MeSH
- Selection, Genetic MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Mitochondrial Proteins MeSH
Organisms living in high altitude must adapt to environmental conditions with hypoxia and low temperature, e.g. by changes in the structure and function of proteins associated with oxidative phosphorylation in mitochondria. Here we analysed the signs of adaptive evolution in 27 mitogenomes of endemic Ethiopian rats (Stenocephalemys), where individual species adapted to different elevation. Significant signals of positive selection were detected in 10 of the 13 mitochondrial protein-coding genes, with a majority of functional substitutions in the NADH dehydrogenase complex. Higher frequency of positively selected sites was found in phylogenetic lineages corresponding to Afroalpine specialists.
A N Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences Moscow Russia
Institute of Vertebrate Biology of the Czech Academy of Sciences Brno Czech Republic
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