Mitogenomics of the endemic Ethiopian rats: looking for footprints of adaptive evolution in sky islands
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33412336
DOI
10.1016/j.mito.2020.12.015
PII: S1567-7249(20)30246-4
Knihovny.cz E-zdroje
- Klíčová slova
- Adaptation, Adaptive introgression, NADH dehydrogenase, Oxidative phosphorylation, Positive selection, dN/dS,
- MeSH
- fylogeneze MeSH
- genová introgrese MeSH
- mitochondriální proteiny chemie genetika MeSH
- mitochondrie genetika MeSH
- molekulární evoluce MeSH
- molekulární modely MeSH
- Murinae klasifikace genetika MeSH
- oxidativní fosforylace MeSH
- sekvenční analýza DNA metody MeSH
- selekce (genetika) MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- mitochondriální proteiny MeSH
Organisms living in high altitude must adapt to environmental conditions with hypoxia and low temperature, e.g. by changes in the structure and function of proteins associated with oxidative phosphorylation in mitochondria. Here we analysed the signs of adaptive evolution in 27 mitogenomes of endemic Ethiopian rats (Stenocephalemys), where individual species adapted to different elevation. Significant signals of positive selection were detected in 10 of the 13 mitochondrial protein-coding genes, with a majority of functional substitutions in the NADH dehydrogenase complex. Higher frequency of positively selected sites was found in phylogenetic lineages corresponding to Afroalpine specialists.
A N Severtsov Institute of Ecology and Evolution of the Russian Academy of Sciences Moscow Russia
Institute of Vertebrate Biology of the Czech Academy of Sciences Brno Czech Republic
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