Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
IGA_PrF_2020_021
Internal Grant Agency of Palacký University in Olomouc, Czech Republic
20-15621S
The Czech Grant Agency
CZ.02.1.01/0.0/0.0/16_019/0000868
The European Regional Development Fund - Project ENOCH
2017
student grant from Palacký University's Endowment Fund
PubMed
33445611
PubMed Central
PMC7827283
DOI
10.3390/molecules26020361
PII: molecules26020361
Knihovny.cz E-zdroje
- Klíčová slova
- Parkinson’s disease, cytokinin, cytotoxicity, glutamate, neuron-like SH-SY5Y cells, neuroprotection, oxidative stress, phytohormone, salsolinol,
- MeSH
- acetylcystein farmakologie MeSH
- biologické modely * MeSH
- buněčná diferenciace účinky léků MeSH
- buněčná smrt účinky léků MeSH
- cytokininy farmakologie terapeutické užití MeSH
- isochinoliny farmakologie MeSH
- kaspasa 3 metabolismus MeSH
- kaspasa 7 metabolismus MeSH
- kyselina glutamová toxicita MeSH
- kyslík metabolismus MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- neurony účinky léků MeSH
- neuroprotektivní látky farmakologie terapeutické užití MeSH
- oxidační stres účinky léků MeSH
- Parkinsonova nemoc farmakoterapie patologie MeSH
- regulátory růstu rostlin farmakologie MeSH
- superoxidy metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcystein MeSH
- cytokininy MeSH
- isochinoliny MeSH
- kaspasa 3 MeSH
- kaspasa 7 MeSH
- kyselina glutamová MeSH
- kyslík MeSH
- neuroprotektivní látky MeSH
- regulátory růstu rostlin MeSH
- salsolinol MeSH Prohlížeč
- superoxidy MeSH
Cytokinins are adenine-based phytohormones that regulate key processes in plants, such as cell division and differentiation, root and shoot growth, apical dominance, branching, and seed germination. In preliminary studies, they have also shown protective activities against human neurodegenerative diseases. To extend knowledge of the protection (protective activity) they offer, we investigated activities of natural cytokinins against salsolinol (SAL)-induced toxicity (a Parkinson's disease model) and glutamate (Glu)-induced death of neuron-like dopaminergic SH-SY5Y cells. We found that kinetin-3-glucoside, cis-zeatin riboside, and N6-isopentenyladenosine were active in the SAL-induced PD model. In addition, trans-, cis-zeatin, and kinetin along with the iron chelator deferoxamine (DFO) and the necroptosis inhibitor necrostatin 1 (NEC-1) significantly reduced cell death rates in the Glu-induced model. Lactate dehydrogenase assays revealed that the cytokinins provided lower neuroprotective activity than DFO and NEC-1. Moreover, they reduced apoptotic caspase-3/7 activities less strongly than DFO. However, the cytokinins had very similar effects to DFO and NEC-1 on superoxide radical production. Overall, they showed protective activity in the SAL-induced model of parkinsonian neuronal cell death and Glu-induced model of oxidative damage mainly by reduction of oxidative stress.
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