Surface Microdialysis for Detection of Colorectal Anastomosis Ischemia-An Experimental Study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem
PubMed
33477078
DOI
10.1016/j.jss.2020.12.021
PII: S0022-4804(20)30882-9
Knihovny.cz E-zdroje
- Klíčová slova
- Anastomotic leak, Anterior resection, Microdialysis,
- MeSH
- anastomóza chirurgická škodlivé účinky MeSH
- glycerol metabolismus MeSH
- ischemie diagnóza etiologie metabolismus MeSH
- krevní glukóza analýza MeSH
- kyselina mléčná metabolismus MeSH
- mikrodialýza metody MeSH
- miniaturní prasata MeSH
- pooperační komplikace diagnóza etiologie metabolismus MeSH
- prasata MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- glycerol MeSH
- krevní glukóza MeSH
- kyselina mléčná MeSH
BACKGROUND: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through monitoring of tissue metabolism. In this experimental study, we assessed the role of microdialysis in detecting early ischemia after colorectal anastomosis. MATERIALS AND METHODS: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. RESULTS: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline; P < 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hours-from a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P < 0.005). The decrease in glucose levels was also significant after 60 minutes-0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia. CONCLUSIONS: Surface microdialysis can detect ischemic changes early and may be a promising method in postoperative monitoring of colorectal anastomosis.
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