Blunt injury of liver: mechanical response of porcine liver in experimental impact test
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33482651
DOI
10.1088/1361-6579/abdf3c
Knihovny.cz E-zdroje
- MeSH
- dopravní nehody MeSH
- játra zranění MeSH
- lidé MeSH
- poranění břicha * MeSH
- prasata MeSH
- tlak MeSH
- tupá poranění * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: The liver is frequently injured in blunt abdominal trauma caused by road traffic accidents. The testing of safety performance of vehicles, e.g. belt usage, head support, seat shape, or air bag shape, material, pressure and reaction, could lead to reduction of the injury seriousness. Current trends in safety testing include development of accurate computational human body models (HBMs) based on the anatomical, morphological, and mechanical behavior of tissues under high strain. APPROACH: The aim of this study was to describe the internal pressure changes within porcine liver, the severity of liver injury and the relation between the porcine liver microstructure and rupture propagation in an experimental impact test. Porcine liver specimens (n = 24) were uniformly compressed using a drop tower technique and four impact heights (200, 300, 400 and 500 mm; corresponding velocities: 1.72, 2.17, 2.54 and 2.88 m s-1). The changes in intravascular pressure were measured via catheters placed in portal vein and caudate vena cava. The induced injuries were analyzed on the macroscopic level according to AAST grade and AIS severity. Rupture propagation with respect to liver microstructure was analyzed using stereological methods. MAIN RESULTS: Macroscopic ruptures affected mostly the interface between connective tissue surrounding big vessels and liver parenchyma. Histological analysis revealed that the ruptures avoided reticular fibers and interlobular septa made of connective tissue on the microscopic level. SIGNIFICANCE: The present findings can be used for evaluation of HBMs of liver behavior in impact situations.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Anatomy Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Mechanics Faculty of Applied Sciences University of West Bohemia Pilsen Czech Republic
New Technologies Research Centre University of West Bohemia Pilsen Czech Republic
Citace poskytuje Crossref.org
