Assessment of Waldeyer's ring in pediatric and adolescent Hodgkin lymphoma patients-Importance of multimodality imaging: Results from the EuroNet-PHL-C1 trial
Language English Country United States Media print-electronic
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
33538093
DOI
10.1002/pbc.28903
Knihovny.cz E-resources
- Keywords
- 18F-FDG-PET, CT, ENT investigation, MRI, Waldeyer's ring, multimodality imaging, pediatric Hodgkin lymphoma, staging,
- MeSH
- Child MeSH
- Fluorodeoxyglucose F18 analysis MeSH
- Hodgkin Disease diagnostic imaging MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Adolescent MeSH
- Multimodal Imaging MeSH
- Tomography, X-Ray Computed MeSH
- Positron-Emission Tomography MeSH
- Child, Preschool MeSH
- Neoplasm Staging MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fluorodeoxyglucose F18 MeSH
BACKGROUND: In the EuroNet Pediatric Hodgkin Lymphoma (EuroNet-PHL) trials, decision on Waldeyer's ring (WR) involvement is usually based on clinical assessment, that is, physical examination and/or nasopharyngoscopy. However, clinical assessment only evaluates mucosal surface and is prone to interobserver variability. Modern cross-sectional imaging technology may provide valuable information beyond mucosal surface, which may lead to a more accurate WR staging. PATIENTS, MATERIALS, AND METHODS: The EuroNet-PHL-C1 trial recruited 2102 patients, of which 1752 underwent central review including reference reading of their cross-sectional imaging data. In 14 of 1752 patients, WR was considered involved according to clinical assessment. In these 14 patients, the WR was re-assessed by applying an imaging-based algorithm considering information from 18 F-fluorodeoxyglucose positron emission tomography, contrast-enhanced computed tomography, and/or magnetic resonance imaging. For verification purposes, the imaging-based algorithm was applied to 100 consecutive patients whose WR was inconspicuous on clinical assessment. RESULTS: The imaging-based algorithm confirmed WR involvement only in four of the 14 patients. Of the remaining 10 patients, four had retropharyngeal lymph node involvement and six an inconspicuous WR. Applying the imaging-based algorithm to 100 consecutive patients with physiological appearance of their WR on clinical assessment, absence of WR involvement could be confirmed in 99. However, suspicion of WR involvement was raised in one patient. CONCLUSIONS: The imaging-based algorithm was feasible and easily applicable at initial staging of young patients with Hodgkin lymphoma. It increased the accuracy of WR staging, which may contribute to a more individualized treatment in the future.
Department of Ear Nose and Throat Medicine Hospital Martha Maria Halle Halle Germany
Department of Medical Oncology and Radiotherapy Oslo University Hospital Oslo Norway
Department of Nuclear Medicine Justus Liebig University Giessen Giessen Germany
Department of Nuclear Medicine University of Leipzig Leipzig Germany
Department of Pediatric Hematology and Oncology Justus Liebig University Gießen Germany
Department of Pediatric Hematology and Oncology Our Lady's Children's Hospital Dublin Ireland
Department of Pediatric Hematology and Oncology University Children's Hospital Bratislava Slovakia
Department of Pediatric Hematology and Oncology University College London Hospitals London UK
Department of Pediatric Hematology and Oncology University Hospitals Leuven Leuven Belgium
Department of Radiation Oncology Medical Faculty of the Martin Luther University Halle Germany
Department of Radiation Oncology University Hospital Vienna Vienna Austria
Department of Radiology and Nuclear Medicine Oslo University Hospital Oslo Norway
Department of Radiology Justus Liebig University Giessen Giessen Germany
Department of Radiology Medical Faculty of the Martin Luther University Halle Germany
Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands
Hôpital Armand Trousseau Sorbonne Universitè Paris France
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Institute of Pediatrics Jagiellonian University Medical College Krakow Poland
Karolinska University Hospital Astrid Lindgrens Childrens Hospital Stockholm Sweden
Medical Faculty of the Martin Luther University Halle Germany
Pediatric Onco Hematology Unit Hospital Universitario Virgen Macarena Sevilla Spain
Princess Màxima Center for Pediatric Oncology Utrecht The Netherlands
Service d'Hématologie Pédiatrique Hôpital Robert Debré Paris France
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