Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life
Jazyk angličtina Země Spojené státy americké Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
33602913
PubMed Central
PMC7891472
DOI
10.1038/s41408-021-00432-4
PII: 10.1038/s41408-021-00432-4
Knihovny.cz E-zdroje
- MeSH
- klinické zkoušky, fáze III jako téma MeSH
- kvalita života MeSH
- lidé MeSH
- management nemoci MeSH
- mnohočetný myelom * farmakoterapie MeSH
- protinádorové látky * škodlivé účinky terapeutické užití MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- protinádorové látky * MeSH
Treatment options in multiple myeloma (MM) are increasing with the introduction of complex multi-novel-agent-based regimens investigated in randomized clinical trials. However, application in the real-world setting, including feasibility of and adherence to these regimens, may be limited due to varying patient-, treatment-, and disease-related factors. Furthermore, approximately 40% of real-world MM patients do not meet the criteria for phase 3 studies on which approvals are based, resulting in a lack of representative phase 3 data for these patients. Therefore, treatment decisions must be tailored based on additional considerations beyond clinical trial efficacy and safety, such as treatment feasibility (including frequency of clinic/hospital attendance), tolerability, effects on quality of life (QoL), and impact of comorbidities. There are multiple factors of importance to real-world MM patients, including disease symptoms, treatment burden and toxicities, ability to participate in daily activities, financial burden, access to treatment and treatment centers, and convenience of treatment. All of these factors are drivers of QoL and treatment satisfaction/compliance. Importantly, given the heterogeneity of MM, individual patients may have different perspectives regarding the most relevant considerations and goals of their treatment. Patient perspectives/goals may also change as they move through their treatment course. Thus, the 'efficacy' of treatment means different things to different patients, and treatment decision-making in the context of personalized medicine must be guided by an individual's composite definition of what constitutes the best treatment choice. This review summarizes the various factors of importance and practical issues that must be considered when determining real-world treatment choices. It assesses the current instruments, methodologies, and recent initiatives for analyzing the MM patient experience. Finally, it suggests options for enhancing data collection on patients and treatments to provide a more holistic definition of the effectiveness of a regimen in the real-world setting.
Department of Hematologic Oncology and Blood Disorders Levine Cancer Institute Charlotte NC USA
Department of Hematology University Hospital of Salamanca IBSAL CIC IBMCC Salamanca Spain
Department of Lymphoma and Myeloma MD Anderson Cancer Center Houston TX USA
Leeds Cancer Centre Leeds Teaching Hospitals Trust Leeds UK
Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY USA
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