Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary Delphi-based consensus
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33657677
DOI
10.1111/bjd.19893
Knihovny.cz E-zdroje
- MeSH
- dítě MeSH
- dospělí MeSH
- konsensus MeSH
- lidé MeSH
- retrospektivní studie MeSH
- Stevensův-Johnsonův syndrom * diagnóza terapie MeSH
- výzkum MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Supportive care is the cornerstone of management of adult and paediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, consensus on the modalities of supportive care is lacking. OBJECTIVES: Our aim in this international multicentric Delphi exercise was to establish a multidisciplinary expert consensus to standardize recommendations regarding supportive care in the acute phase of SJS/TEN. METHODS: Participants were sent a survey via the online tool SurveyMonkey, consisting of 103 statements organized into 11 topics: multidisciplinary team composition, suspect drug management, infection prevention, fluid resuscitation and prevention of hypothermia, nutritional support, pain and psychological distress management, management of acute respiratory failure, local skincare, ophthalmological management, management of other mucosa, and additional measures. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). The results were analysed according to the RAND/UCLA Appropriateness Method. RESULTS: Forty-five participants from 13 countries (on three continents) participated. After the first round, a consensus was obtained for 82.5% of the 103 initially proposed statements. After the second round, a final consensus was obtained for 102 statements. CONCLUSIONS: We have reached an international Delphi-based consensus on best supportive care practice for SJS/TEN. Our expert consensus should help guide physicians in treating patients with SJS/TEN and thereby improve short-term prognosis and the risk of sequelae.
Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA
Birmingham Children's Hospital and University of Birmingham Birmingham UK
Christine Kühne Center for Allergy Research and Education Davos Switzerland
Clinical Experimental Sciences Faculty of Medicine University of Southampton Southampton UK
Department of Dermatology Aarhus University Hospital Palle Juul Jensens Aarhus Denmark
Department of Dermatology and Allergy University Hospital of Munich LMU Munich Germany
Department of Dermatology AP HP Necker Hospital Paris France
Department of Dermatology Brigham and Women's Hospital Harvard Medical School Boston MA USA
Department of Dermatology CHU Bordeaux Bordeaux France
Department of Dermatology CHU Charles Nicolle Rouen France
Department of Dermatology King's College Hospital London UK
Department of Dermatology Kyorin University School of Medicine Tokyo Japan
Department of Dermatology Leiden University Medical Center Leiden the Netherlands
Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Department of Dermatology University Hospital Zurich Zurich Switzerland
Department of Dermatology University of California Davis Sacramento CA USA
Department of Dermatology University of California San Francisco CA USA
Department of Medicine and Pharmacology Vanderbilt University Medical Center Nashville TN USA
Department of Psychiatry AP HP Henri Mondor Albert Chenevier Hospitals Cr France
Dermatology Department AP HP Henri Mondor Hospital Créteil France
Division of Clinical Pharmacology and Toxicology University of Toronto Toronto ON Canada
Division of Dermatology Department of Internal Medicine Ohio State University Columbus OH USA
Division of Dermatology Sunnybrook Health Sciences Centre Toronto ON Canada
Faculty of Medicine University of Zurich Zurich Switzerland
Intensive Care Unit AP HP Henri Mondor Hospital Créteil France
Keck USC School of Medicine Los Angeles CA USA
Macmillan Skin Cancer CNS Normanby Building Denmark Hill London UK
Massachusetts General Hospital Harvard Medical School Boston MA USA
Niigata University Graduate School of Medical and Dental Sciences Niigata Japan
Ophthalmology Department Hospital Charles Nicolle EA7510 UFR Santé Rouen University Rouen France
Réanimation Chirurgicale et des Brûlés PTMC CHU Nantes Nantes France
ToxiTEN Group European Reference Network for Rare Skin Diseases Paris France
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Kuijper EC, French LE, Tensen CP et al. Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN). J Eur Acad Dermatol Venereol 2020; 34:1957-71.
Duong TA, Valeyrie-Allanore L, Wolkenstein P, Chosidow O. Severe cutaneous adverse reactions to drugs. Lancet 2017; 390:1996-2011.
Mockenhaupt M, Viboud C, Dunant A et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 2008; 128:35-44.
Sekula P, Dunant A, Mockenhaupt M et al. Comprehensive survival analysis of a cohort of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. J Invest Dermatol 2013; 133:1197-204.
Micheletti RG, Chiesa-Fuxench Z, Noe MH et al. Stevens-Johnson syndrome/toxic epidermal necrolysis: a multicentre retrospective study of 377 adult patients from the United States. J Invest Dermatol 2018; 138:2315-21.
Bettuzzi T, Penso L, de Prost N et al. Trends in mortality rates for Stevens-Johnson syndrome and toxic epidermal necrolysis: experience of a single centre in France between 1997 and 2017. Br J Dermatol 2020; 182:247-8.
Chaby G, Maldini C, Haddad C et al. Incidence of and mortality from epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis) in France during 2003-16: a four-source capture-recapture estimate. Br J Dermatol 2020; 182:618-24.
Sassolas B, Haddad C, Mockenhaupt M et al. ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson syndrome and toxic epidermal necrolysis: comparison with case-control analysis. Clin Pharmacol Ther 2010; 88:60-8.
Chaby G, Ingen-Housz-Oro S, De Prost N et al. Idiopathic Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and patients’ characteristics. J Am Acad Dermatol 2019; 80:1453-5.
Bastuji-Garin S, Fouchard N, Bertocchi M et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000; 115:149-53.
Hsu DY, Brieva J, Silverberg NB, Silverberg JI. Morbidity and mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis in United States adults. J Invest Dermatol 2016; 136:1387-97.
Ingen-Housz-Oro S, Alves A, Colin A et al. Health-related quality of life and long-term sequelae in survivors of epidermal necrolysis: an observational study of 57 patients. Br J Dermatol 2020; 182:916-26.
Lee HY, Walsh SA, Creamer D. Long-term complications of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN): the spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multidisciplinary follow-up. Br J Dermatol 2017; 177:924-35.
Heng YK, Lee HY, Roujeau J-C. Epidermal necrolysis: 60 years of errors and advances. Br J Dermatol 2015; 173:1250-4.
Auquier-Dunant A, Mockenhaupt M, Naldi L et al. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol 2002; 138:1019-24.
Bequignon E, Duong TA, Sbidian E et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: ear, nose, and throat description at acute stage and after remission. JAMA Dermatol 2015; 151:302-7.
Gueudry J, Roujeau J-C, Binaghi M et al. Risk factors for the development of ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 2009; 145:157-62.
Gendreau S, Amiot A, Le Baleur Y et al. Gastrointestinal involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective case series. Br J Dermatol 2019; 180:1234-5.
Roujeau JC. Toxic epidermal necrolysis (Lyell syndrome): more than ‘acute skin failure’. Intensive Care Med 1992; 18:4-5.
Lecadet A, Woerther P-L, Hua C et al. Incidence of bloodstream infections and predictive value of qualitative and quantitative skin cultures of patients with overlap syndrome or toxic epidermal necrolysis: a retrospective observational cohort study of 98 cases. J Am Acad Dermatol 2019; 81:342-7.
Koh HK, Chai ZT, Tay HW et al. Risk factors and diagnostic markers of bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: a cohort study of 176 patients. J Am Acad Dermatol 2019; 81:686-93.
de Prost N, Mekontso-Dessap A, Valeyrie-Allanore L et al. Acute respiratory failure in patients with toxic epidermal necrolysis: clinical features and factors associated with mechanical ventilation. Crit Care Med 2014; 42:118-28.
Lebargy F, Wolkenstein P, Gisselbrecht M et al. Pulmonary complications in toxic epidermal necrolysis: a prospective clinical study. Intensive Care Med 1997; 23:1237-44.
Ingen-Housz-Oro S, Duong T-A, Bensaid B et al. Epidermal necrolysis French national diagnosis and care protocol (PNDS; Protocole National de Diagnostic et de Soins). Orphanet J Rare Dis 2018; 13:56.
Kaffenberger BH, Rosenbach M. Toxic epidermal necrolysis and early transfer to a regional burn unit: is it time to reevaluate what we teach? J Am Acad Dermatol 2014; 71:195-6.
Creamer D, Walsh SA, Dziewulski P et al. UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016. Br J Dermatol 2016; 174:1194-227.
Traikia C, Hua C, Le Cleach L et al. Individual- and hospital-level factors associated with epidermal necrolysis mortality: a nationwide multilevel study, France, 2012-2016. Br J Dermatol 2020; 182:900-6.
Wolkenstein P, Latarjet J, Roujeau JC et al. Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis. Lancet 1998; 352:1586-9.
Wang C-W, Yang L-Y, Chen C-B et al. Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions. J Clin Invest 2018; 128:985-96.
Ingen-Housz-Oro S, Duong T-A, de Prost N et al. [Treatment of severe cutaneous adverse drug reactions]. Ann Dermatol Venereol 2018; 145:454-64 (in French).
White KD, Abe R, Ardern-Jones M et al. SJS/TEN 2017: building multidisciplinary networks to drive science and translation. J Allergy Clin Immunol Pract 2018; 6:38-69.
Zimmermann S, Sekula P, Venhoff M et al. Systemic immunomodulating therapies for Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. JAMA Dermatol 2017; 153:514-22.
McPherson T, Exton LS, Biswas S et al. British Association of Dermatologists’ guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in children and young people, 2018. Br J Dermatol 2019; 181:37-54.
Jandhyala R. Delphi, non-RAND modified Delphi, RAND of UCLA appropriateness method and a novel group awareness and consensus methodology for consensus measurement: a systematic literature review. Curr Med Res Opin 2020; 36:1873-87.
Garcia-Doval I, LeCleach L, Bocquet H et al. Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol 2000; 136:323-7.
Ingen-Housz-Oro S, Le Floch R, Alves A et al. Carrying out local care for epidermal necrolysis: survey of practices. J Eur Acad Dermatol Venereol 2021; 35:e155-e157.
Singer M, Deutschman CS, Seymour CW et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315:801-10.
Inamadar AC, Palit A. Acute skin failure: concept, causes, consequences and care. Indian J Dermatol Venereol Leprol 2005; 71:379-85.
Hefez L, Zaghbib K, Sbidian E et al. Post-traumatic stress disorder in Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and risk factors. A prospective study of 31 patients. Br J Dermatol 2019; 180:1206-13.
Castillo B, Vera N, Ortega-Loayza AG, Seminario-Vidal L. Reply to: ‘Wound management strategies in Stevens-Johnson syndrome/toxic epidermal necrolysis: an unmet need’. J Am Acad Dermatol 2018; 79:e89.
Lee HY. Wound management strategies in Stevens-Johnson syndrome/toxic epidermal necrolysis: an unmet need. J Am Acad Dermatol 2018; 79:e87-e88.
Hajj C, Ezzedine K, Thorel D et al. Disabling ocular sequelae of epidermal necrolysis: risk factors during the acute phase and associated sequelae. Br J Dermatol 2019; 181:421-2.
Thorel D, Ingen-Housz-Oro S, Royer G et al. Management of ocular involvement in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: French national audit of practices, literature review, and consensus agreement. Orphanet J Rare Dis 2020; 15:259.
Seminario-Vidal L, Kroshinsky D, Malachowski SJ et al. Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults. J Am Acad Dermatol 2020; 82:1553-67.