Insect Growth Regulators (IGRs) represent advanced, bio-rational insecticides. This Special Issue reflects progress in IGR development that has been enabled by insight into the molecular principles of biosynthetic or hormone signaling pathways. The unifying principle is aiming at processes and molecular targets that are unique to arthropods and ideally to narrower insect taxa representing pests or disease vectors. While some strategies of obtaining the desired compounds for chemical intervention rely on rational, structure-based design or computational power, others exploit technologies allowing automated, high-throughput screening of large chemical libraries. All avenues leading to selective and environmentally safe pest control are valid as we face the imminent threat of the declining world insect population.

Biology Center of the Czech Academy of Sciences Institute of Entomology Ceske Budejovice 370 05 Czech Republic

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D. L. Wagner, E. M. Grames, M. L. Forister, M. R. Berenbaum and D. Stopak: Insect decline in the Anthropocene: Death by a thousand cuts. PubMed PMC

Y. Li, L. Liu, J. Yang and Q. Yang: An overall look at insect chitin deacetylases: Promising molecular targets for developing green pesticides. PubMed PMC

Y. Mushiake, A. Tsuchida, A. Yamada, H. Kanzaki, T. Okuda and T. Nitoda: New analogs of pochonicine, a potent β- PubMed PMC

K. Mori, H. Tokuoka, H. Miyagawa and Y. Nakagawa: Isoxaben analogs inhibit chitin synthesis in the cultured integument of the rice stem borer ( PubMed PMC

I. M. L. Billas, T. Iwema, J. M. Garnier, A. Mitschler, N. Rochel and D. Moras: Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. PubMed

J. A. Carmichael, M. C. Lawrence, L. D. Graham, P. A. Pilling, V. C. Epa, L. Noyce, G. Lovrecz, D. A. Winkler, A. Pawlak-Skrzecz, R. E. Eaton, G. N. Hannan and R. J. Hill: The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: Comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design. PubMed

R. J. Hill, I. M. L. Billas, F. Bonneton, L. D. Graham and M. C. Lawrence: Ecdysone receptors: From the Ashburner model to structural biology. PubMed

J.-P. Charles, T. Iwema, V. C. Epa, K. Takaki, J. Rynes and M. Jindra: Ligand binding properties of a juvenile hormone receptor, Methoprene-tolerant. PubMed PMC

T. Kayukawa, C. Minakuchi, T. Namiki, T. Togawa, M. Yoshiyama, M. Kamimura, K. Mita, S. Imanishi, M. Kiuchi, Y. Ishikawa and T. Shinoda: Transcriptional regulation of juvenile hormone-1 mediated induction of Krüppel homolog 1, a repressor of insect metamorphosis. PubMed PMC

M. Jindra, X. Bellés and T. Shinoda: Molecular basis of juvenile hormone signaling. PubMed

M.-È. Picard, M. Cusson, S. S. Sen and R. Shi: Rational design of Lepidoptera-specific insecticidal inhibitors targeting farnesyl diphosphate synthase, a key enzyme of the juvenile hormone biosynthetic pathway. PubMed PMC

W. G. Goodman and M. Cusson: The juvenile hormones. In “Insect Endocrinology,” ed. by L. I. Gilbert, Elsevier, Amsterdam, pp. 310–365 (2012).

M.-È. Picard, A. Nisole, C. Béliveau, S. E. Sen, A. Barbar, R. Shi and M. Cusson: Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, PubMed

K. Koiwai, K. Morohashi, K. Inaba, K. Ebihara, H. Kojima, T. Okabe, R. Yoshino, T. Hirokawa, T. Nampo, Y. Fujikawa, H. Inoue, F. Yumoto, T. Senda and R. Niwa: Non-steroidal inhibitors of PubMed PMC

S. Enya, T. Ameku, F. Igarashi, M. Iga, H. Kataoka, T. Shinoda and R. Niwa: A Halloween gene PubMed PMC

N. Okamoto and N. Yamanaka: Transporter-mediated ecdysteroid trafficking across cell membranes: a novel target for insect growth regulators. PubMed PMC

N. Okamoto, R. Viswanatha, R. Bittar, Z. Li, S. Haga-Yamanaka, N. Perrimon and N. Yamanaka: A membrane transporter is required for steroid hormone uptake in PubMed PMC

N. Okamoto and N. Yamanaka: Steroid hormone entry into the brain requires a membrane transporter in PubMed PMC

C. Browning, A. G. McEwen, K. Mori, T. Yokoi, D. Moras, Y. Nakagawa and I. M. L. Billas: Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP. PubMed PMC

M. Ueno, T. Yokoi, Y. Nakagawa and H. Miyagawa: Receptor-binding affinity and larvicidal activity of tetrahydroquinoline-type ecdysone agonists against PubMed PMC

S. Ito-Harashima and T. Yagi: Reporter gene assays for screening and identification of novel molting hormone- and juvenile hormone-like chemicals. PubMed PMC

S.-H. Lee, H.-W. Oh, Y. Fang, S.-B. An, D.-S. Park, H.-H. Song, S.-R. Oh, S.-Y. Kim, S. Kim, N. Kim, A. S. Raikhel, Y. H. Je and S. W. Shin: Identification of plant compounds that disrupt the insect juvenile hormone receptor complex. PubMed PMC

T. Kayukawa, K. Furuta, K. Nagamine, T. Shinoda, K. Yonesu and T. Okabe: Identification of a juvenile-hormone signaling inhibitor PubMed PMC

T. Kayukawa, K. Furuta, K. Yonesu and T. Okabe: Identification of novel juvenile-hormone signaling activators PubMed PMC

L. Bittova, P. Jedlicka, M. Dracinsky, P. Kirubakaran, J. Vondrasek, R. Hanus and M. Jindra: Exquisite ligand stereoselectivity of a PubMed PMC

M. Jindra and L. Bittova: The juvenile hormone receptor as a target of juvenoid “insect growth regulators”. PubMed

T. Yokoi, T. Nabe, S. Horoiwa, K. Hayashi, S. Ito-Harashima, T. Yagi, Y. Nakagawa and H. Miyagawa: Virtual screening identifies a novel piperazine-based insect juvenile hormone agonist. PubMed PMC

T. Yokoi, T. Nabe, C. Ishizuka, K. Hayashi, S. Ito-Harashima, T. Yagi, Y. Nakagawa and H. Miyagawa: Transcription-inducing activity of natural and synthetic juvenile hormone agonists through the PubMed

J. W. Truman and L. M. Riddiford: The origins of insect metamorphosis. PubMed

M. Jindra: Where did the pupa come from? The timing of juvenile hormone signalling supports homology between stages of hemimetabolous and holometabolous insects. PubMed PMC

D. F. Erezyilmaz, L. M. Riddiford and J. W. Truman: Juvenile hormone acts at embryonic molts and induces the nymphal cuticle in the direct-developing cricket. PubMed

S. Naruse, M. Ogino, T. Nakagawa, Y. Yasuno, A. Jouraku, T. Shiotsuki, T. Shinoda, K. Miura and C. Minakuchi: Ovicidal activity of juvenile hormone mimics in the bean bug, PubMed PMC

Y. Ando, K. Matsumoto, K. Misaki, G. Mano, S. Shiga, H. Numata, T. Kotaki, T. Shinada and S. G. Goto: Juvenile hormone III skipped bisepoxide, not its stereoisomers, as a juvenile hormone of the bean bug PubMed

R. Parthasarathy and S. R. Palli: Stage-specific action of juvenile hormone analogs. PubMed PMC

E. Satoh, R. Kasahara, K. Fukatsu, T. Aoki, H. Harayama and T. Murata: Benzpyrimoxan: design, synthesis, and biological activity of a novel insecticide. PubMed PMC