Local Angiotensin-Converting Enzyme 2 Gene Expression in Kidney Allografts Is Not Affected by Renin-Angiotensin-Aldosterone Inhibitors
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
33756485
PubMed Central
PMC8089425
DOI
10.1159/000513710
PII: 000513710
Knihovny.cz E-zdroje
- Klíčová slova
- Angiotensin-converting enzyme 2, COVID-19, Kidney, Renin-angiotensin system inhibitors,
- MeSH
- alografty účinky léků metabolismus MeSH
- angiotensin-konvertující enzym 2 analýza antagonisté a inhibitory genetika MeSH
- antagonisté receptorů pro angiotenzin farmakologie terapeutické užití MeSH
- antihypertenziva farmakologie terapeutické užití MeSH
- COVID-19 komplikace genetika MeSH
- dospělí MeSH
- exprese genu účinky léků MeSH
- ledviny účinky léků metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA analýza genetika MeSH
- renin-angiotensin systém účinky léků MeSH
- senioři MeSH
- transplantace ledvin MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ACE2 protein, human MeSH Prohlížeč
- angiotensin-konvertující enzym 2 MeSH
- antagonisté receptorů pro angiotenzin MeSH
- antihypertenziva MeSH
- messenger RNA MeSH
BACKGROUND: Preclinical studies suggested that pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) by ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) may increase local angiotensin-converting enzyme 2 (ACE2) expression. METHODS: In this study, we evaluated the effect of ACEi or ARB treatment on expression of ACE2, ACE, and AGTR1 in 3-month protocol kidney allograft biopsies of stable patients using RT-qPCR (n = 48). Protein ACE2 expression was assessed using immunohistochemistry from paraffin sections. RESULTS: The therapy with RAAS blockers was not associated with increased ACE2, ACE, or ATGR1 expression in kidney allografts and also ACE2 protein immunohistochemistry did not reveal differences among groups. CONCLUSIONS: ACEis or ARBs in kidney transplant recipients do not affect local ACE2 expression. This observation supports long-term RAAS treatment in kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.
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