Potent Cyclic Tetrapeptide for Lead Detoxification
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- chelation therapy, lead poisoning, metal selectivity, peptides, rational design,
- MeSH
- HT29 Cells MeSH
- Peptides, Cyclic chemistry metabolism MeSH
- Humans MeSH
- Oligopeptides chemistry metabolism MeSH
- Lead chemistry metabolism toxicity MeSH
- Protein Binding MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Peptides, Cyclic MeSH
- Oligopeptides MeSH
- Lead MeSH
Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state-of-the-art drugs. The Pb-peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning.
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