COVID-19 severe pneumonia: Prospective multicentre study on demands on intensive care capacities
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie
PubMed
33831279
DOI
10.21101/cejph.a6672
Knihovny.cz E-zdroje
- Klíčová slova
- COVID-19, intensive care, kidney disease, mortality, respiratory failure,
- MeSH
- COVID-19 * MeSH
- dospělí MeSH
- lidé MeSH
- mortalita v nemocnicích MeSH
- péče o pacienty v kritickém stavu MeSH
- prospektivní studie MeSH
- SARS-CoV-2 MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
OBJECTIVES: The aim of the study was to obtain data on demands on the intensive care capacities to treat COVID-19 patients, and to identify predictors for in-hospital mortality. METHODS: The prospective observational multicentre study carried out from 1 March till 30 June 2020 included adult patients with confirmed SARS-CoV-2 infection with respiratory failure requiring ventilatory support or high-flow nasal oxygen therapy (HFNO). RESULTS: Seventy-four patients, 46 males and 28 females, median age 67.5 (Q1-Q3: 56-75) years, were included. Sixty-four patients (86.5%) had comorbidity. Sixty-six patients (89.2%) were mechanically ventilated, four of them received extracorporeal membrane oxygenation therapy. Eight patients (10.8%) were treated with non-invasive ventilation and HFNO only. The median of intensive care unit (ICU) stay was 22.5 days. Eighteen patients (24.3%) needed continuous renal replacement therapy. Thirty patients (40.5%) died. Age and acute kidney injury were identified as independent predictors of in-hospital death, and chronic kidney disease showed trend towards statistical significance for poor outcome. CONCLUSIONS: Sufficient number of intensive care beds, organ support equipment and well-trained staff is a decisive factor in managing the COVID-19 epidemic. The study focused on the needs of intensive care in the COVID-19 patients. Advanced age and acute kidney injury were identified as independent predictors for in-hospital mortality. When compared to clinical course and ICU management of patients with severe community-acquired pneumonia caused by other pathogens, we observed prolonged need for ventilatory support, high rate of progression to acute respiratory distress syndrome and significant mortality in studied population.
Department of Anaesthesiology and Reanimation Hospital Na Homolce Prague Czech Republic
Department of Anaesthesiology and Resuscitation Hospital Na Bulovce Prague Czech Republic
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