The determination of contaminants of emerging concern (CECs) in environmental samples has become a challenging and critical issue. The present work focuses on miniaturized analytical strategies reported in the literature for the determination of CECs. The first part of the review provides brief overview of CECs whose monitoring in environmental samples is of particular significance, namely personal care products, pharmaceuticals, endocrine disruptors, UV-filters, newly registered pesticides, illicit drugs, disinfection by-products, surfactants, high technology rare earth elements, and engineered nanomaterials. Besides, an overview of downsized sample preparation approaches reported in the literature for the determination of CECs in environmental samples is provided. Particularly, analytical methodologies involving microextraction approaches used for the enrichment of CECs are discussed. Both solid phase- and liquid phase-based microextraction techniques are highlighted devoting special attention to recently reported approaches. Special emphasis is placed on newly developed materials used for extraction purposes in microextraction techniques. In addition, recent contributions involving miniaturized analytical flow techniques for the determination of CECs are discussed. Besides, the strengths, weaknesses, opportunities and threats of point of need and portable devices have been identified and critically compared with chromatographic methods coupled to mass chromatography. Finally, challenging aspects regarding miniaturized analytical methods for determination of CECs are critically discussed.

Centro de Investigación Mariña Universidade de Vigo Departamento de Química Analítica e Alimentaria Grupo QA2 Edificio CC Experimentais Campus de Vigo As Lagoas Marcosende 36310 Vigo Spain

Cranfield Water Science Institute Cranfield University Cranfield MK43 0AL United Kingdom

Cranfield Water Science Institute Cranfield University Cranfield MK43 0AL United Kingdom; School of Engineering University of Glasgow G12 8LT United Kingdom

Departamento de Medio Ambiente y Agronomía INIA Carretera de A Coruña Km 7 5 Madrid E 28040 Spain

Department of Analytical Chemistry Faculty of Chemical Engineering and Technology University of Zagreb Marulićev Trg 19 Zagreb 10000 Croatia

Department of Nanobiotechnology Biology Centre ISB CAS Na Sadkach 7 370 05 Ceske Budejovice Czech Republic; Regional Centre of Advanced Technologies and Materials Palacky University Slechtitelu 27 783 71 Olomouc Czech Republic

Department of Nanobiotechnology Biology Centre ISB CAS Na Sadkach 7 370 05 Ceske Budejovice Czech Republic; Regional Centre of Advanced Technologies and Materials Palacky University Slechtitelu 27 783 71 Olomouc Czech Republic; Department of Magnetism Institute of Experimental Physics SAS Watsonova 47 040 01 Kosice Slovakia

Laboratory of Aquatic Chemistry School of Environmental Engineering Polytechnioupolis Technical University of Crete GR 73100 Chania Crete Greece

LAQV REQUIMTE Department of Chemical Sciences Faculty of Pharmacy University of Porto R Jorge Viterbo Ferreira 228 4050 313 Porto Portugal

School of Engineering University of Glasgow G12 8LT United Kingdom

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