An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization
Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
33913454
DOI
10.1039/d1dt00740h
Knihovny.cz E-resources
- MeSH
- Iodine chemistry pharmacology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Organoplatinum Compounds chemistry pharmacology MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Solutions MeSH
- Drug Screening Assays, Antitumor MeSH
- Thermodynamics MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- amminedichloro(2-methylpyridine)platinum(II) MeSH Browser
- Iodine MeSH
- Organoplatinum Compounds MeSH
- Antineoplastic Agents MeSH
- Solutions MeSH
Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.
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