lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma

. 2021 Apr 29 ; 11 (5) : . [epub] 20210429

Jazyk angličtina Země Švýcarsko Médium electronic

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid33947142

Grantová podpora
NV18-03-00554 Ministerstvo Zdravotnictví Ceské Republiky

LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. In this review, we summarize the literature focused on PVT1 in RCC and aim to synthesize the current knowledge on its role in the cells of the kidney. Further, we provide an overview of the lncRNA profiling studies that have identified a more or less significant association of PVT1 with the clinical behavior of RCC. Based on our search, we analyzed the 17 scientific papers discussed in this review that provide robust support for the indispensable role of PVT1 in RCC development and future personalized therapy.

Zobrazit více v PubMed

Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. PubMed DOI

Capitanio U., Bensalah K., Bex A., Boorjian S.A., Bray F., Coleman J., Gore J.L., Sun M., Wood C., Russo P. Epidemiology of Renal Cell Carcinoma. Eur. Urol. 2019;75:74–84. doi: 10.1016/j.eururo.2018.08.036. PubMed DOI PMC

Athanazio D.A., Amorim L.S., da Cunha I.W., Leite K.R.M., da Paz A.R., de Paula Xavier Gomes R., Tavora F.R.F., Faraj S.F., Cavalcanti M.S., Bezerra S.M. Classification of Renal Cell Tumors–Current Concepts and Use of Ancillary Tests: Recommendations of the Brazilian Society of Pathology. Surg. Exp. Pathol. 2021;4:4. doi: 10.1186/s42047-020-00084-x. DOI

Warren A.Y., Harrison D. WHO/ISUP Classification, Grading and Pathological Staging of Renal Cell Carcinoma: Standards and Controversies. World J. Urol. 2018;36:1913–1926. doi: 10.1007/s00345-018-2447-8. PubMed DOI PMC

Escudier B., Porta C., Schmidinger M., Rioux-Leclercq N., Bex A., Khoo V., Grünwald V., Gillessen S., Horwich A. ESMO Guidelines Committee Renal Cell Carcinoma: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Ann. Oncol. 2019;30:706–720. doi: 10.1093/annonc/mdz056. PubMed DOI

Lopez-Beltran A., Henriques V., Cimadamore A., Santoni M., Cheng L., Gevaert T., Blanca A., Massari F., Scarpelli M., Montironi R. The Identification of Immunological Biomarkers in Kidney Cancers. Front. Oncol. 2018;8:456. doi: 10.3389/fonc.2018.00456. PubMed DOI PMC

Jabandziev P., Kakisaka T., Bohosova J., Pinkasova T., Kunovsky L., Slaby O., Goel A. MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification. J. Clin. Med. 2021;10:1325. doi: 10.3390/jcm10061325. PubMed DOI PMC

Brito G.C., Fachel A.A., Vettore A.L., Vignal G.M., Gimba E.R.P., Campos F.S., Barcinski M.A., Verjovski-Almeida S., Reis E.M. Identification of Protein-Coding and Intronic Noncoding RNAs down-Regulated in Clear Cell Renal Carcinoma. Mol. Carcinog. 2008;47:757–767. doi: 10.1002/mc.20433. PubMed DOI

Yu G., Yao W., Wang J., Ma X., Xiao W., Li H., Xia D., Yang Y., Deng K., Xiao H., et al. LncRNAs Expression Signatures of Renal Clear Cell Carcinoma Revealed by Microarray. PLoS ONE. 2012;7:e42377. doi: 10.1371/journal.pone.0042377. PubMed DOI PMC

Zou B., Wang D., Xu K., Liu J., Yuan D., Meng Z., Zhang B. Prognostic Value of Long Non-Coding RNA Plasmacytoma Variant Translocation1 in Human Solid Tumors. Medicine. 2019;98:e16087. doi: 10.1097/MD.0000000000016087. PubMed DOI PMC

International Human Genome Sequencing Consortium Finishing the Euchromatic Sequence of the Human Genome. Nature. 2004;431:931–945. doi: 10.1038/nature03001. PubMed DOI

Harrow J., Frankish A., Gonzalez J.M., Tapanari E., Diekhans M., Kokocinski F., Aken B.L., Barrell D., Zadissa A., Searle S., et al. GENCODE: The Reference Human Genome Annotation for The ENCODE Project. Genome Res. 2012;22:1760–1774. doi: 10.1101/gr.135350.111. PubMed DOI PMC

Djebali S., Davis C.A., Merkel A., Dobin A., Lassmann T., Mortazavi A., Tanzer A., Lagarde J., Lin W., Schlesinger F., et al. Landscape of Transcription in Human Cells. Nature. 2012;489:101–108. doi: 10.1038/nature11233. PubMed DOI PMC

Frith M.C., Pheasant M., Mattick J.S. The Amazing Complexity of the Human Transcriptome. Eur. J. Hum. Genet. 2005;13:894–897. doi: 10.1038/sj.ejhg.5201459. PubMed DOI

Fang S., Zhang L., Guo J., Niu Y., Wu Y., Li H., Zhao L., Li X., Teng X., Sun X., et al. NONCODEV5: A Comprehensive Annotation Database for Long Non-Coding RNAs. Nucleic Acids Res. 2018;46:D308–D314. doi: 10.1093/nar/gkx1107. PubMed DOI PMC

Ravasi T., Suzuki H., Pang K.C., Katayama S., Furuno M., Okunishi R., Fukuda S., Ru K., Frith M.C., Gongora M.M., et al. Experimental Validation of the Regulated Expression of Large Numbers of Non-Coding RNAs from the Mouse Genome. Genome Res. 2006;16:11–19. doi: 10.1101/gr.4200206. PubMed DOI PMC

Mercer T.R., Dinger M.E., Sunkin S.M., Mehler M.F., Mattick J.S. Specific Expression of Long Noncoding RNAs in the Mouse Brain. Proc. Natl. Acad. Sci. USA. 2008;105:716–721. doi: 10.1073/pnas.0706729105. PubMed DOI PMC

Cabili M.N., Trapnell C., Goff L., Koziol M., Tazon-Vega B., Regev A., Rinn J.L. Integrative Annotation of Human Large Intergenic Noncoding RNAs Reveals Global Properties and Specific Subclasses. Genes Dev. 2011;25:1915–1927. doi: 10.1101/gad.17446611. PubMed DOI PMC

Derrien T., Johnson R., Bussotti G., Tanzer A., Djebali S., Tilgner H., Guernec G., Martin D., Merkel A., Knowles D.G., et al. The GENCODE v7 Catalog of Human Long Noncoding RNAs: Analysis of Their Gene Structure, Evolution, and Expression. Genome Res. 2012;22:1775–1789. doi: 10.1101/gr.132159.111. PubMed DOI PMC

Bánfai B., Jia H., Khatun J., Wood E., Risk B., Gundling W.E., Kundaje A., Gunawardena H.P., Yu Y., Xie L., et al. Long Noncoding RNAs Are Rarely Translated in Two Human Cell Lines. Genome Res. 2012;22:1646–1657. doi: 10.1101/gr.134767.111. PubMed DOI PMC

Chooniedass-Kothari S., Emberley E., Hamedani M.K., Troup S., Wang X., Czosnek A., Hube F., Mutawe M., Watson P.H., Leygue E. The Steroid Receptor RNA Activator Is the First Functional RNA Encoding a Protein. FEBS Lett. 2004;566:43–47. doi: 10.1016/j.febslet.2004.03.104. PubMed DOI

Kondo T., Plaza S., Zanet J., Benrabah E., Valenti P., Hashimoto Y., Kobayashi S., Payre F., Kageyama Y. Small Peptides Switch the Transcriptional Activity of Shavenbaby during Drosophila Embryogenesis. Science. 2010;329:336–339. doi: 10.1126/science.1188158. PubMed DOI

Guttman M., Amit I., Garber M., French C., Lin M.F., Feldser D., Huarte M., Zuk O., Carey B.W., Cassady J.P., et al. Chromatin Signature Reveals over a Thousand Highly Conserved Large Non-Coding RNAs in Mammals. Nature. 2009;458:223–227. doi: 10.1038/nature07672. PubMed DOI PMC

Yang L., Duff M.O., Graveley B.R., Carmichael G.G., Chen L.-L. Genomewide Characterization of Non-Polyadenylated RNAs. Genome Biol. 2011;12:R16. doi: 10.1186/gb-2011-12-2-r16. PubMed DOI PMC

Wu H., Yang L., Chen L.-L. The Diversity of Long Noncoding RNAs and Their Generation. Trends Genet. 2017;33:540–552. doi: 10.1016/j.tig.2017.05.004. PubMed DOI

Wang J., Zhang J., Zheng H., Li J., Liu D., Li H., Samudrala R., Yu J., Wong G.K.-S. Mouse Transcriptome: Neutral Evolution of “non-Coding” Complementary DNAs. Nature. 2004;14:431. PubMed

Mercer T.R., Dinger M.E., Mattick J.S. Long Non-Coding RNAs: Insights into Functions. Nat. Rev. Genet. 2009;10:155–159. doi: 10.1038/nrg2521. PubMed DOI

Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., et al. The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309:1559–1563. doi: 10.1126/science.1112014. PubMed DOI

Ponjavic J., Ponting C.P., Lunter G. Functionality or Transcriptional Noise? Evidence for Selection within Long Noncoding RNAs. Genome Res. 2007;17:556–565. doi: 10.1101/gr.6036807. PubMed DOI PMC

Marques A.C., Ponting C.P. Catalogues of Mammalian Long Noncoding RNAs: Modest Conservation and Incompleteness. Genome Biol. 2009;10:R124. doi: 10.1186/gb-2009-10-11-r124. PubMed DOI PMC

Ørom U.A., Derrien T., Beringer M., Gumireddy K., Gardini A., Bussotti G., Lai F., Zytnicki M., Notredame C., Huang Q., et al. Long Noncoding RNAs with Enhancer-like Function in Human Cells. Cell. 2010;143:46–58. doi: 10.1016/j.cell.2010.09.001. PubMed DOI PMC

Statello L., Guo C.-J., Chen L.-L., Huarte M. Gene Regulation by Long Non-Coding RNAs and Its Biological Functions. Nat. Rev. Mol. Cell Biol. 2020;22:96–118. doi: 10.1038/s41580-020-00315-9. PubMed DOI PMC

de Oliveira J.C., Oliveira L.C., Mathias C., Pedroso G.A., Lemos D.S., Salviano-Silva A., Jucoski T.S., Lobo-Alves S.C., Zambalde E.P., Cipolla G.A., et al. Long Non-Coding RNAs in Cancer: Another Layer of Complexity. J. Gene Med. 2019;21:e3065. doi: 10.1002/jgm.3065. PubMed DOI

Wang K.C., Chang H.Y. Molecular Mechanisms of Long Noncoding RNAs. Mol. Cell. 2011;43:904–914. doi: 10.1016/j.molcel.2011.08.018. PubMed DOI PMC

Chen L.-L. Linking Long Noncoding RNA Localization and Function. Trends Biochem. Sci. 2016;41:761–772. doi: 10.1016/j.tibs.2016.07.003. PubMed DOI

Schmitz K.-M., Mayer C., Postepska A., Grummt I. Interaction of Noncoding RNA with the RDNA Promoter Mediates Recruitment of DNMT3b and Silencing of RRNA Genes. Genes Dev. 2010;24:2264–2269. doi: 10.1101/gad.590910. PubMed DOI PMC

Di Ruscio A., Ebralidze A.K., Benoukraf T., Amabile G., Goff L.A., Terragni J., Figueroa M.E., De Figueiredo Pontes L.L., Alberich-Jorda M., Zhang P., et al. DNMT1-Interacting RNAs Block Gene-Specific DNA Methylation. Nature. 2013;503:371–376. doi: 10.1038/nature12598. PubMed DOI PMC

Khalil A.M., Guttman M., Huarte M., Garber M., Raj A., Rivea Morales D., Thomas K., Presser A., Bernstein B.E., van Oudenaarden A., et al. Many Human Large Intergenic Noncoding RNAs Associate with Chromatin-Modifying Complexes and Affect Gene Expression. Proc. Natl. Acad. Sci. USA. 2009;106:11667–11672. doi: 10.1073/pnas.0904715106. PubMed DOI PMC

Sun Q., Hao Q., Prasanth K.V. Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression. Trends Genet. 2018;34:142–157. doi: 10.1016/j.tig.2017.11.005. PubMed DOI PMC

Lam M.T.Y., Li W., Rosenfeld M.G., Glass C.K. Enhancer RNAs and Regulated Transcriptional Programs. Trends Biochem. Sci. 2014;39:170–182. doi: 10.1016/j.tibs.2014.02.007. PubMed DOI PMC

Feng J., Bi C., Clark B.S., Mady R., Shah P., Kohtz J.D. The Evf-2 Noncoding RNA Is Transcribed from the Dlx-5/6 Ultraconserved Region and Functions as a Dlx-2 Transcriptional Coactivator. Genes Dev. 2006;20:1470–1484. doi: 10.1101/gad.1416106. PubMed DOI PMC

Shamovsky I., Ivannikov M., Kandel E.S., Gershon D., Nudler E. RNA-Mediated Response to Heat Shock in Mammalian Cells. Nature. 2006;440:556–560. doi: 10.1038/nature04518. PubMed DOI

Yang L., Lin C., Jin C., Yang J.C., Tanasa B., Li W., Merkurjev D., Ohgi K.A., Meng D., Zhang J., et al. LncRNA-Dependent Mechanisms of Androgen-Receptor-Regulated Gene Activation Programs. Nature. 2013;500:598–602. doi: 10.1038/nature12451. PubMed DOI PMC

Lai F., Orom U.A., Cesaroni M., Beringer M., Taatjes D.J., Blobel G.A., Shiekhattar R. Activating RNAs Associate with Mediator to Enhance Chromatin Architecture and Transcription. Nature. 2013;494:497–501. doi: 10.1038/nature11884. PubMed DOI PMC

Tian D., Sun S., Lee J.T. The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation. Cell. 2010;143:390–403. doi: 10.1016/j.cell.2010.09.049. PubMed DOI PMC

Sun S., Del Rosario B.C., Szanto A., Ogawa Y., Jeon Y., Lee J.T. Jpx RNA Activates Xist by Evicting CTCF. Cell. 2013;153:1537–1551. doi: 10.1016/j.cell.2013.05.028. PubMed DOI PMC

Wang X., Arai S., Song X., Reichart D., Du K., Pascual G., Tempst P., Rosenfeld M.G., Glass C.K., Kurokawa R. Induced NcRNAs Allosterically Modify RNA-Binding Proteins in Cis to Inhibit Transcription. Nature. 2008;454:126–130. doi: 10.1038/nature06992. PubMed DOI PMC

Martianov I., Ramadass A., Serra Barros A., Chow N., Akoulitchev A. Repression of the Human Dihydrofolate Reductase Gene by a Non-Coding Interfering Transcript. Nature. 2007;445:666–670. doi: 10.1038/nature05519. PubMed DOI

Ramos A.D., Andersen R.E., Liu S.J., Nowakowski T.J., Hong S.J., Gertz C., Salinas R.D., Zarabi H., Kriegstein A.R., Lim D.A. The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells. Cell Stem Cell. 2015;16:439–447. doi: 10.1016/j.stem.2015.02.007. PubMed DOI PMC

Gonzalez I., Munita R., Agirre E., Dittmer T.A., Gysling K., Misteli T., Luco R.F. A LncRNA Regulates Alternative Splicing via Establishment of a Splicing-Specific Chromatin Signature. Nat. Struct. Mol. Biol. 2015;22:370–376. doi: 10.1038/nsmb.3005. PubMed DOI PMC

Gong C., Maquat L.E. LncRNAs Transactivate STAU1-Mediated MRNA Decay by Duplexing with 3’ UTRs via Alu Elements. Nature. 2011;470:284–288. doi: 10.1038/nature09701. PubMed DOI PMC

Damas N.D., Marcatti M., Côme C., Christensen L.L., Nielsen M.M., Baumgartner R., Gylling H.M., Maglieri G., Rundsten C.F., Seemann S.E., et al. SNHG5 Promotes Colorectal Cancer Cell Survival by Counteracting STAU1-Mediated MRNA Destabilization. Nat. Commun. 2016;7:13875. doi: 10.1038/ncomms13875. PubMed DOI PMC

Hu G., Lou Z., Gupta M. The Long Non-Coding RNA GAS5 Cooperates with the Eukaryotic Translation Initiation Factor 4E to Regulate c-Myc Translation. PLoS ONE. 2014;9:e107016. doi: 10.1371/journal.pone.0107016. PubMed DOI PMC

Carrieri C., Cimatti L., Biagioli M., Beugnet A., Zucchelli S., Fedele S., Pesce E., Ferrer I., Collavin L., Santoro C., et al. Long Non-Coding Antisense RNA Controls Uchl1 Translation through an Embedded SINEB2 Repeat. Nature. 2012;491:454–457. doi: 10.1038/nature11508. PubMed DOI

Salmena L., Poliseno L., Tay Y., Kats L., Pandolfi P.P. A CeRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? Cell. 2011;146:353–358. doi: 10.1016/j.cell.2011.07.014. PubMed DOI PMC

Kino T., Hurt D.E., Ichijo T., Nader N., Chrousos G.P. Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor. Sci. Signal. 2010;3:ra8. doi: 10.1126/scisignal.2000568. PubMed DOI PMC

Lee S., Kopp F., Chang T.-C., Sataluri A., Chen B., Sivakumar S., Yu H., Xie Y., Mendell J.T. Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins. Cell. 2016;164:69–80. doi: 10.1016/j.cell.2015.12.017. PubMed DOI PMC

Yoon J.-H., Abdelmohsen K., Kim J., Yang X., Martindale J.L., Tominaga-Yamanaka K., White E.J., Orjalo A.V., Rinn J.L., Kreft S.G., et al. Scaffold Function of Long Non-Coding RNA HOTAIR in Protein Ubiquitination. Nat. Commun. 2013;4:2939. doi: 10.1038/ncomms3939. PubMed DOI PMC

Yang F., Zhang H., Mei Y., Wu M. Reciprocal Regulation of HIF-1α and LincRNA-P21 Modulates the Warburg Effect. Mol. Cell. 2014;53:88–100. doi: 10.1016/j.molcel.2013.11.004. PubMed DOI

Willingham A.T., Orth A.P., Batalov S., Peters E.C., Wen B.G., Aza-Blanc P., Hogenesch J.B., Schultz P.G. A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT. Science. 2005;309:1570–1573. doi: 10.1126/science.1115901. PubMed DOI

Noh J.H., Kim K.M., Abdelmohsen K., Yoon J.-H., Panda A.C., Munk R., Kim J., Curtis J., Moad C.A., Wohler C.M., et al. HuR and GRSF1 Modulate the Nuclear Export and Mitochondrial Localization of the LncRNA RMRP. Genes Dev. 2016;30:1224–1239. doi: 10.1101/gad.276022.115. PubMed DOI PMC

Vučićević D., Schrewe H., Orom U.A. Molecular Mechanisms of Long NcRNAs in Neurological Disorders. Front. Genet. 2014;5:48. doi: 10.3389/fgene.2014.00048. PubMed DOI PMC

Faghihi M.A., Modarresi F., Khalil A.M., Wood D.E., Sahagan B.G., Morgan T.E., Finch C.E., St Laurent G., Kenny P.J., Wahlestedt C. Expression of a Noncoding RNA Is Elevated in Alzheimer’s Disease and Drives Rapid Feed-Forward Regulation of Beta-Secretase. Nat. Med. 2008;14:723–730. doi: 10.1038/nm1784. PubMed DOI PMC

Goyal N., Kesharwani D., Datta M. Lnc-Ing Non-Coding RNAs with Metabolism and Diabetes: Roles of LncRNAs. Cell. Mol. Life Sci. 2018;75:1827–1837. doi: 10.1007/s00018-018-2760-9. PubMed DOI PMC

Xu F., Jin L., Jin Y., Nie Z., Zheng H. Long Noncoding RNAs in Autoimmune Diseases. J. Biomed. Mater. Res. A. 2019;107:468–475. doi: 10.1002/jbm.a.36562. PubMed DOI

Jabandziev P., Bohosova J., Pinkasova T., Kunovsky L., Slaby O., Goel A. The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease. Inflamm. Bowel Dis. 2020;26:985–993. doi: 10.1093/ibd/izaa009. PubMed DOI PMC

Hennessy E.J. Cardiovascular Disease and Long Noncoding RNAs: Tools for Unraveling the Mystery Lnc-Ing RNA and Phenotype. Circ. Cardiovasc. Genet. 2017;10:e001556. doi: 10.1161/CIRCGENETICS.117.001556. PubMed DOI

Bhan A., Soleimani M., Mandal S.S. Long Noncoding RNA and Cancer: A New Paradigm. Cancer Res. 2017;77:3965–3981. doi: 10.1158/0008-5472.CAN-16-2634. PubMed DOI PMC

Hanahan D., Weinberg R.A. The Hallmarks of Cancer. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9. PubMed DOI

Gutschner T., Diederichs S. The Hallmarks of Cancer: A Long Non-Coding RNA Point of View. RNA Biol. 2012;9:703–719. doi: 10.4161/rna.20481. PubMed DOI PMC

Schmitt A.M., Chang H.Y. Long Noncoding RNAs in Cancer Pathways. Cancer Cell. 2016;29:452–463. doi: 10.1016/j.ccell.2016.03.010. PubMed DOI PMC

Hanahan D., Weinberg R.A. Hallmarks of Cancer: The next Generation. Cell. 2011;144:646–674. doi: 10.1016/j.cell.2011.02.013. PubMed DOI

Yang T., Zhou H., Liu P., Yan L., Yao W., Chen K., Zeng J., Li H., Hu J., Xu H., et al. LncRNA PVT1 and Its Splicing Variant Function as Competing Endogenous RNA to Regulate Clear Cell Renal Cell Carcinoma Progression. Oncotarget. 2017;8:85353–85367. doi: 10.18632/oncotarget.19743. PubMed DOI PMC

Lu D., Luo P., Wang Q., Ye Y., Wang B. LncRNA PVT1 in Cancer: A Review and Meta-Analysis. Clin. Chim Acta. 2017;474:1–7. doi: 10.1016/j.cca.2017.08.038. PubMed DOI

Li W., Zheng Z., Chen H., Cai Y., Xie W. Knockdown of Long Non-Coding RNA PVT1 Induces Apoptosis and Cell Cycle Arrest in Clear Cell Renal Cell Carcinoma through the Epidermal Growth Factor Receptor Pathway. Oncol. Lett. 2018;15:7855–7863. doi: 10.3892/ol.2018.8315. PubMed DOI PMC

Zhang Y., Tan Y., Wang H., Xu M., Xu L. Long Non-Coding RNA Plasmacytoma Variant Translocation 1 (PVT1) Enhances Proliferation, Migration, and Epithelial-Mesenchymal Transition (EMT) of Pituitary Adenoma Cells by Activating β-Catenin, c-Myc, and Cyclin D1 Expression. Med. Sci. Monit. 2019;25:7652–7659. doi: 10.12659/MSM.917110. PubMed DOI PMC

Ren Y., Huang W., Weng G., Cui P., Liang H., Li Y. LncRNA PVT1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells through Downregulation of MiR-16-5p. OncoTargets Ther. 2019;12:2563–2575. doi: 10.2147/OTT.S190239. PubMed DOI PMC

Zeidler R., Joos S., Delecluse H.J., Klobeck G., Vuillaume M., Lenoir G.M., Bornkamm G.W., Lipp M. Breakpoints of Burkitt’s Lymphoma t(8;22) Translocations Map within a Distance of 300 Kb Downstream of MYC. Genes Chromosomes Cancer. 1994;9:282–287. doi: 10.1002/gcc.2870090408. PubMed DOI

Jin K., Wang S., Zhang Y., Xia M., Mo Y., Li X., Li G., Zeng Z., Xiong W., He Y. Long Non-Coding RNA PVT1 Interacts with MYC and Its Downstream Molecules to Synergistically Promote Tumorigenesis. Cell Mol. Life Sci. 2019;76:4275–4289. doi: 10.1007/s00018-019-03222-1. PubMed DOI PMC

Perciavalle R.M., Opferman J.T. Delving Deeper: MCL-1’s Contributions to Normal and Cancer Biology. Trends Cell Biol. 2013;23:22–29. doi: 10.1016/j.tcb.2012.08.011. PubMed DOI PMC

Wu Q., Yang F., Yang Z., Fang Z., Fu W., Chen W., Liu X., Zhao J., Wang Q., Hu X., et al. Long Noncoding RNA PVT1 Inhibits Renal Cancer Cell Apoptosis by Up-Regulating Mcl-1. Oncotarget. 2017;8:101865–101875. doi: 10.18632/oncotarget.21706. PubMed DOI PMC

Wang H., Li Z.-Y., Xu Z.-H., Chen Y.-L., Lu Z.-Y., Shen D.-Y., Lu J.-Y., Zheng Q.-M., Wang L.-Y., Xu L.-W., et al. The Prognostic Value of MiRNA-18a-5p in Clear Cell Renal Cell Carcinoma and Its Function via the MiRNA-18a-5p/HIF1A/PVT1 Pathway. J. Cancer. 2020;11:2737–2748. doi: 10.7150/jca.36822. PubMed DOI PMC

Latif F., Tory K., Gnarra J., Yao M., Duh F.M., Orcutt M.L., Stackhouse T., Kuzmin I., Modi W., Geil L. Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene. Science. 1993;260:1317–1320. doi: 10.1126/science.8493574. PubMed DOI

Gnarra J.R., Tory K., Weng Y., Schmidt L., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.M. Mutations of the VHL Tumour Suppressor Gene in Renal Carcinoma. Nat. Genet. 1994;7:85–90. doi: 10.1038/ng0594-85. PubMed DOI

Shuin T., Kondo K., Torigoe S., Kishida T., Kubota Y., Hosaka M., Nagashima Y., Kitamura H., Latif F., Zbar B. Frequent Somatic Mutations and Loss of Heterozygosity of the von Hippel-Lindau Tumor Suppressor Gene in Primary Human Renal Cell Carcinomas. Cancer Res. 1994;54:2852–2855. PubMed

Herman J.G., Latif F., Weng Y., Lerman M.I., Zbar B., Liu S., Samid D., Duan D.S., Gnarra J.R., Linehan W.M. Silencing of the VHL Tumor-Suppressor Gene by DNA Methylation in Renal Carcinoma. Proc. Natl. Acad. Sci. USA. 1994;91:9700–9704. doi: 10.1073/pnas.91.21.9700. PubMed DOI PMC

Kaelin W.G. Molecular Basis of the VHL Hereditary Cancer Syndrome. Nat. Rev. Cancer. 2002;2:673–682. doi: 10.1038/nrc885. PubMed DOI

Kaelin W.G. Von Hippel-Lindau Disease. Annu. Rev. Pathol. 2007;2:145–173. doi: 10.1146/annurev.pathol.2.010506.092049. PubMed DOI

Grampp S., Platt J.L., Lauer V., Salama R., Kranz F., Neumann V.K., Wach S., Stöhr C., Hartmann A., Eckardt K.-U., et al. Genetic Variation at the 8q24.21 Renal Cancer Susceptibility Locus Affects HIF Binding to a MYC Enhancer. Nat. Commun. 2016;7:1–11. doi: 10.1038/ncomms13183. PubMed DOI PMC

Schödel J., Bardella C., Sciesielski L.K., Brown J.M., Pugh C.W., Buckle V., Tomlinson I.P., Ratcliffe P.J., Mole D.R. Common Genetic Variants at the 11q13.3 Renal Cancer Susceptibility Locus Influence Binding of HIF to an Enhancer of Cyclin D1 Expression. Nat. Genet. 2012;44:420–425. doi: 10.1038/ng.2204. PubMed DOI PMC

Vaishnave S. BMI1 and PTEN Are Key Determinants of Breast Cancer Therapy: A Plausible Therapeutic Target in Breast Cancer. Gene. 2018;678:302–311. doi: 10.1016/j.gene.2018.08.022. PubMed DOI

Caramel J., Ligier M., Puisieux A. Pleiotropic Roles for ZEB1 in Cancer. Cancer Res. 2018;78:30–35. doi: 10.1158/0008-5472.CAN-17-2476. PubMed DOI

Yu X., Wang W., Lin X., Zheng X., Yang A. Roles of ZEB2 and RBM38 in Liver Cancer Stem Cell Proliferation. J. BUON. 2020;25:1390–1394. PubMed

Wu H., Wei M., Jiang X., Tan J., Xu W., Fan X., Zhang R., Ding C., Zhao F., Shao X., et al. LncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing MiR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis. Mol. Ther. Nucleic Acids. 2020;20:438–450. doi: 10.1016/j.omtn.2020.03.006. PubMed DOI PMC

Huang C., Yuan N., Wu L., Wang X., Dai J., Song P., Li F., Xu C., Zhao X. An Integrated Analysis for Long Noncoding RNAs and MicroRNAs with the Mediated Competing Endogenous RNA Network in Papillary Renal Cell Carcinoma. OncoTargets Ther. 2017;10:4037–4050. doi: 10.2147/OTT.S141951. PubMed DOI PMC

Chu S. Transcriptional Regulation by Post-Transcriptional Modification--Role of Phosphorylation in Sp1 Transcriptional Activity. Gene. 2012;508:1–8. doi: 10.1016/j.gene.2012.07.022. PubMed DOI

Wang W., Zhou R., Wu Y., Liu Y., Su W., Xiong W., Zeng Z. PVT1 Promotes Cancer Progression via MicroRNAs. Front. Oncol. 2019;9:609. doi: 10.3389/fonc.2019.00609. PubMed DOI PMC

Posa I., Carvalho S., Tavares J., Grosso A.R. A Pan-Cancer Analysis of MYC-PVT1 Reveals CNV-Unmediated Deregulation and Poor Prognosis in Renal Carcinoma. Oncotarget. 2016;7:47033–47041. doi: 10.18632/oncotarget.9487. PubMed DOI PMC

Liu H., Ye T., Yang X., Lv P., Wu X., Zhou H., Zeng J., Tang K., Ye Z. A Panel of Four-LncRNA Signature as a Potential Biomarker for Predicting Survival in Clear Cell Renal Cell Carcinoma. J. Cancer. 2020;11:4274–4283. doi: 10.7150/jca.40421. PubMed DOI PMC

Wang J., Zhang C., He W., Gou X. Construction and Comprehensive Analysis of Dysregulated Long Non-Coding RNA-Associated Competing Endogenous RNA Network in Clear Cell Renal Cell Carcinoma. J. Cell. Biochem. 2018;120:2576–2593. doi: 10.1002/jcb.27557. PubMed DOI

Wu Y., Wang Y.-Q., Weng W.-W., Zhang Q.-Y., Yang X.-Q., Gan H.-L., Yang Y.-S., Zhang P.-P., Sun M.-H., Xu M.-D., et al. A Serum-Circulating Long Noncoding RNA Signature Can Discriminate between Patients with Clear Cell Renal Cell Carcinoma and Healthy Controls. Oncogenesis. 2016;5:e192. doi: 10.1038/oncsis.2015.48. PubMed DOI PMC

Xu X., Xu Y., Shi C., Wang B., Yu X., Zou Y., Hu T. A Genome-Wide Comprehensively Analyses of Long Noncoding RNA Profiling and Metastasis Associated LncRNAs in Renal Cell Carcinoma. Oncotarget. 2017;8:87773–87781. doi: 10.18632/oncotarget.21206. PubMed DOI PMC

Bao X., Duan J., Yan Y., Ma X., Zhang Y., Wang H., Ni D., Wu S., Peng C., Fan Y., et al. Upregulation of Long Noncoding RNA PVT1 Predicts Unfavorable Prognosis in Patients with Clear Cell Renal Cell Carcinoma. Cancer Biomark. 2017;21:55–63. doi: 10.3233/CBM-170251. PubMed DOI

Fachel A.A., Tahira A.C., Vilella-Arias S.A., Maracaja-Coutinho V., Gimba E.R.P., Vignal G.M., Campos F.S., Reis E.M., Verjovski-Almeida S. Expression Analysis and in Silico Characterization of Intronic Long Noncoding RNAs in Renal Cell Carcinoma: Emerging Functional Associations. Mol. Cancer. 2013;12:140. doi: 10.1186/1476-4598-12-140. PubMed DOI PMC

Kogure T., Yan I.K., Lin W.-L., Patel T. Extracellular Vesicle–Mediated Transfer of a Novel Long Noncoding RNA TUC339. Genes Cancer. 2013;4:261–272. doi: 10.1177/1947601913499020. PubMed DOI PMC

Hasselmann D.O., Rappl G., Tilgen W., Reinhold U. Extracellular Tyrosinase MRNA within Apoptotic Bodies Is Protected from Degradation in Human Serum. Clin. Chem. 2001;47:1488–1489. doi: 10.1093/clinchem/47.8.1488. PubMed DOI

Kosaka N., Iguchi H., Yoshioka Y., Takeshita F., Matsuki Y., Ochiya T. Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells. J. Biol. Chem. 2010;285:17442–17452. doi: 10.1074/jbc.M110.107821. PubMed DOI PMC

Batagov A.O., Kuznetsov V.A., Kurochkin I.V. Identification of Nucleotide Patterns Enriched in Secreted RNAs as Putative Cis-Acting Elements Targeting Them to Exosome Nano-Vesicles. BMC Genom. 2011;12(Suppl. 3):S18. doi: 10.1186/1471-2164-12-S3-S18. PubMed DOI PMC

Irion U., St Johnston D. Bicoid RNA Localization Requires Specific Binding of an Endosomal Sorting Complex. Nature. 2007;445:554–558. doi: 10.1038/nature05503. PubMed DOI PMC

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...