lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NV18-03-00554
Ministerstvo Zdravotnictví Ceské Republiky
PubMed
33947142
PubMed Central
PMC8145429
DOI
10.3390/biom11050664
PII: biom11050664
Knihovny.cz E-zdroje
- Klíčová slova
- biomarker, diagnosis, long non-coding RNA, prognosis, tumorigenesis,
- MeSH
- karcinom z renálních buněk genetika MeSH
- lidé MeSH
- nádory ledvin genetika MeSH
- pohyb buněk MeSH
- prognóza MeSH
- proliferace buněk MeSH
- regulace genové exprese u nádorů MeSH
- RNA dlouhá nekódující genetika MeSH
- upregulace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- PVT1 long-non-coding RNA, human MeSH Prohlížeč
- RNA dlouhá nekódující MeSH
LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. In this review, we summarize the literature focused on PVT1 in RCC and aim to synthesize the current knowledge on its role in the cells of the kidney. Further, we provide an overview of the lncRNA profiling studies that have identified a more or less significant association of PVT1 with the clinical behavior of RCC. Based on our search, we analyzed the 17 scientific papers discussed in this review that provide robust support for the indispensable role of PVT1 in RCC development and future personalized therapy.
Central European Institute of Technology Masaryk University 625 00 Brno Czech Republic
Department of Biology Faculty of Medicine Masaryk University 625 00 Brno Czech Republic
Department of Pharmacology Faculty of Medicine Masaryk University 625 00 Brno Czech Republic
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