The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

Institute of Preventive Medicine Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic

Zobrazit více v PubMed

ABDEL-MAWLA MY, EL-KASHESHY KA, GHONEMY S, AL BALAT W, ELSAYED AA. Role of osteopontin in psoriasis: An immunohistochemical study. Indian J Dermatol. 2016;61:301–307. doi: 10.4103/0019-5154.182434. PubMed DOI PMC

AKSU F, CALISKAN M, KELES N, EREK TOPRAK A, UZUCAKMAK TK, KOSTEK O, YILMAZ Y, DEMIRCIOGLU K, CEKIN E, OZTURK I, KARADAG AS. Chemerin as a marker of subclinical cardiac involvement in psoriatic patients. Cardiol J. 2017;24:276–283. doi: 10.5603/CJ.a2017.0031. PubMed DOI

AVOGARO A, FADINI GP. Mechanisms of ectopic calcification: Implications for diabetic vasculopathy. Cardiovasc Diagn Ther. 2015;5:343–352. doi: 10.3978/j.issn.2223-3652.2015.06.05. PubMed DOI PMC

BARAN A, FLISIAK I, JAROSZEWICZ J, SWIDERSKA M. Effect of psoriasis activity on serum adiponectin and leptin levels. Postepy Dermatol Alergol. 2015;32:101–106. doi: 10.5114/pdia.2014.40960. PubMed DOI PMC

BERANEK M, FIALA Z, KREMLACEK J, ANDRYS C, KREJSEK J, HAMAKOVA K, CHMELAROVA M, PALICKA V, BORSKA L. Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis. Arch Dermatol Res. 2017;309:815–821. doi: 10.1007/s00403-017-1785-5. PubMed DOI

CHEN X, ZHANG Y, CHEN Q, LI Q, LI Y, LING W. Lower plasma fetuin-a levels are associated with a higher mortality risk in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2017;37:2213–2219. doi: 10.1161/ATVBAHA.117.309700. PubMed DOI

CHIRICOZZI A, ROMANELLI P, VOLPE E, BORSELLINO G, ROMANELLI M. Scanning the immunopathogenesis of psoriasis. Int J Mol Sci. 2018;19:179. doi: 10.3390/ijms19010179. PubMed DOI PMC

CIBICKOVA L, LANGOVA K, VAVERKOVA H, LUKES J, CIBICEK N, KARASEK D. Superior role of waist circumference to body-mass index in the prediction of cardiometabolic risk in dyslipidemic patients. Physiol Res. 2019;68:931–938. doi: 10.33549/physiolres.934176. PubMed DOI

COBAN M, TASLI L, TURGUT S, OOZKAN S, TUNC ATA M, AKIN F. Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris. Ann Dermatol. 2016;28:74–79. doi: 10.5021/ad.2016.28.1.74. PubMed DOI PMC

CTIRAD A, LENKA B, DAVID P, ZDENEK F, KVETA H, KAREL E, JAN K. Goeckerman’s therapy for psoriasis with special reference to serum pentraxin 3 level. Int J Dermatol. 2008;47:1011–1014. doi: 10.1111/j.1365-4632.2008.03666.x. PubMed DOI

DIMITRIADIS GK, KAUR J, ADYA R, MIRAS AD, MATTU HS, HATTERSLEY JG, KALTSAS G, TAN BK, RANDEVA HS. Chemerin induces endothelial cell inflammation: Activation of nuclear factor-kappa beta and monocyte-endothelial adhesion. Oncotarget. 2018;9:16678–16690. doi: 10.18632/oncotarget.24659. PubMed DOI PMC

DONG X, YAN X, ZHANG W, TANG S. Adiponectin enhances biological functions of vascular endothelial progenitor cells through the mTOR-STAT3 signaling pathway. Physiol Res. 2018;67:563–570. doi: 10.33549/physiolres.933738. PubMed DOI

EVRIN PE, NILSSON SE, OBERG T, MALMBERG B. Serum C-reactive protein in elderly men and women: Association with mortality, morbidity and various biochemical values. Scand J Clin Lab Invest. 2005;65:23–31. doi: 10.1080/00365510510013505. PubMed DOI

FERLAND DJ, WATTS SW. Chemerin: A comprehensive review elucidating the need for cardiovascular research. Pharmacol Res. 2015;99:351–361. doi: 10.1016/j.phrs.2015.07.018. PubMed DOI PMC

FILARDI T, CARNEVALE V, MASSOUD R, RUSSO C, NIEDDU L, TAVAGLIONE F, TURINESE I, LENZI A, ROMAGNOLI E, MORANO S. High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes. J Endocrinol Invest. 2019;42:295–301. doi: 10.1007/s40618-018-0914-0. PubMed DOI

GE Q, RUAN CC, MA Y, TANG XF, WU QH, WANG JG, ZHU DL, GAO PJ. Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification. Sci Rep. 2017;7:40253. doi: 10.1038/srep40253. PubMed DOI PMC

GELFAND JM, NEIMANN AL, SHIN DB, WANG X, MARGOLIS DJ, TROXEL AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735–1741. doi: 10.1001/jama.296.14.1735. PubMed DOI

GENC M, CAN M, GUVEN B, CINAR S, BUYUKUYUSAL C, ACIKGOZ B, MUNGAN AG, ACIKGOZ S. Evaluation of serum fetuin-a and osteoprotegerin levels in patients with psoriasis. Indian J Clin Biochem. 2017;32:90–94. doi: 10.1007/s12291-016-0570-0. PubMed DOI PMC

GERDES S, OSADTSCHY S, BUHLES N, BAURECHT H, MROWIETZ U. Cardiovascular biomarkers in patients with psoriasis. Exp Dermatol. 23:322–325. doi: 10.1111/exd.12381. PubMed DOI

GISONDI P, LORA V, BONAUGURI C, RUSSO A, LIPPI G, GIROLOMONI G. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol. 2013;168:749–755. doi: 10.1111/bjd.12118. PubMed DOI

INCI S, AKSAN G, DOGAN P. Chemerin as an independent predictor of cardiovascular risk. Ther Adv Endocrinol Metab. 2016;7:57–68. doi: 10.1177/2042018816629894. PubMed DOI PMC

KASSEM MM, HELKIN A, MAIER KG, GAHTAN V. Thrombospondins differentially regulate proteins involved in arterial remodeling. Physiol Res. 2019;68:893–900. doi: 10.33549/physiolres.934148. PubMed DOI

LI J, CAI Y, WANG Z, DENG A, YANG G. Polymorphisms in the osteopontin are associated with susceptibility to ankylosing spondylitis in a Han Chinese population. Biomed Res Int. 2018;5:1–6. doi: 10.1155/2018/3458439. PubMed DOI PMC

MACHADO-PINTO J, DINIZ MDOS S, BAVOSO NC. Psoriasis: New comorbidities. An Bras Dermatol. 2016;91:8–14. doi: 10.1590/abd1806-4841.20164169. PubMed DOI PMC

MALKIC SALIHBEGOVIC E, HADZIGRAHIC N, CICKUSIC AJ. Psoriasis and metabolic syndrome. Med Arch. 2015;69:85–87. doi: 10.5455/medarh.2015.69.85-87. PubMed DOI PMC

MARIANI F, RONCUCCI L. Chemerin/chemr23 axis in inflammation onset and resolution. Inflamm Res. 2015;64:85–95. doi: 10.1007/s00011-014-0792-7. PubMed DOI

MUKHOPADHYAY S, MONDAL SA, KUMAR M, DUTTA D. Proinflammatory and antiinflammatory attributes of fetuin-a: A novel hepatokine modulating cardiovascular and glycemic outcomes in metabolic syndrome. Endocr Pract. 2014;20:1345–1351. doi: 10.4158/EP14421.RA. PubMed DOI

NAIK HB, NATARAJAN B, STANSKY E, AHLMAN MA, TEAGUE H, SALAHUDDIN T, NG Q, JOSHI A, KRISHNAMOORTHY P, DAVE J, ROSE SM, DOVEIKIS J, PLAYFORD MP, PRUSSICK RB, EHRLICH A, KAPLAN MJ, LOCKSHIN BN, GELFAND JM, MEHTA NN. Severity of psoriasis associates with aortic vascular inflammation detected by FDG PET/CT and neutrophil activation in a prospective observational study. Arterioscler Thromb Vasc Biol. 2015;35:2667–2676. doi: 10.1161/ATVBAHA.115.306460. PubMed DOI PMC

NAKAO M, NAKAMURA K, FUKASAWA T, SHIDA R, ITO A, ICHIMURA Y, TAKAHASHI T, MITSUI A, YOSHIZAKI A, SHIBATA S, KAMATA M, ARAKI M, WATANABE R, SATO S, ASANO Y. Assessment of endothelial function during the loading phase of infliximab in psoriasis: A potential predictor of its drug survival. Int J Dermatol. 2019;58:54–59. doi: 10.1111/ijd.14200. PubMed DOI

PAMPANINI V, INZAGHI E, GERMANI D, ALTERIO A, PUGLIANIELLO A, ALISI A, NOBILI V, CIANFARANI S. Serum fetuin-a levels in obese children with biopsy proven nonalcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2018;28:71–76. doi: 10.1016/j.numecd.2017.09.008. PubMed DOI

SCHREIER M, SCHWARTZE JT, LANDGRAF K, SCHEUERMANN K, ERBS S, HERBERTH G, POSPISILIK JA, KRATZSCH J, KIESS W, KORNER A. Osteopontin is bmi-independently related to early endothelial dysfunction in children. J Clin Endocrinol Metab. 2016;101:4161–4169. doi: 10.1210/jc.2016-2238. PubMed DOI

SIMJAK P, CINKAJZLOVA A, ANDERLOVA K, KLOUCKOVA J, KRATOCHVILOVA H, LACINOVA Z, KAVALKOVA P, KREJCI H, MRAZ M, PARIZEK A, KRSEK M, HALUZIK M. Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes mellitus. Physiol Res. 2018;67(Suppl 3):S531–S542. doi: 10.33549/physiolres.934017. PubMed DOI

SNEKVIK I, NILSEN TIL, ROMUNDSTAD PR, SAUNES M. Psoriasis and cardiovascular disease risk factors: The HUNT study, Norway. J Eur Acad Dermatol Venereol. 2018;32:776–782. doi: 10.1111/jdv.14835. PubMed DOI

STEITZ SA, SPEER MY, McKEE MD, LIAW L, ALMEIDA M, YANG H, GIACHELLI CM. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol. 2002;161:2035–2046. doi: 10.1016/S0002-9440(10)64482-3. PubMed DOI PMC

STROBER B, KARKI C, MASON M, GUO N, HOLMGREN SH, GREENBERG JD. Characterization of disease burden, comorbidities, and treatment use in a large, us-based cohort: Results from the corrona psoriasis registry. J Am Acad Dermatol. 2018;78:323–332. doi: 10.1016/j.jaad.2017.10.012. PubMed DOI

SUDHESAN A, RAJAPPA M, CHANDRASHEKAR L, ANANTHANARAYANAN PH, THAPPA DM, SATHEESH S, CHANDASEKARAN A, DEVARAJU P. Association of c-reactive protein (rs1205) gene polymorphism with susceptibility to psoriasis in south Indian Tamils. J Clin Diagn Res. 2016;10:GC01–GC04. doi: 10.7860/JCDR/2016/23391.8624. PubMed DOI PMC

UZ O, KARDESOGLU E, YIGINER O, BAS S, IPCIOGLU OM, OZMEN N, APARCI M, CINGOZBAY BY, ISILAK Z, CEBECI BS. The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-a, and visfatin. Turk Kardiyol Dern Ars. 2009;37:397–402. PubMed

VADAKAYIL AR, DANDEKERI S, KAMBIL SM, ALI NM. Role of c-reactive protein as a marker of disease severity and cardiovascular risk in patients with psoriasis. Indian Dermatol Online J. 2015;6:322–325. doi: 10.4103/2229-5178.164483. PubMed DOI PMC

VASSALLE C, MAZZONE A. Bone loss and vascular calcification: A bi-directional interplay? Vascul Pharmacol. 2016;86:77–86. doi: 10.1016/j.vph.2016.07.003. PubMed DOI

VENA GA, VESTITA M, CASSANO N. Psoriasis and cardiovascular disease. Dermatol Ther. 2010;23:144–151. doi: 10.1111/j.1529-8019.2010.01308.x. PubMed DOI

WOO YR, CHO DH, PARK HJ. Molecular mechanisms and management of a cutaneous inflammatory disorder: Psoriasis. Int J Mol Sci. 2017;18:2684. doi: 10.3390/ijms18122684. PubMed DOI PMC

YEH ET, WILLERSON JT. Coming of age of c-reactive protein: Using inflammation markers in cardiology. Circulation. 2003;107:370–371. doi: 10.1161/01.CIR.0000053731.05365.5A. PubMed DOI

ZABEL BA, ALLEN SJ, KULIG P, ALLEN JA, CICHY J, HANDEL TM, BUTCER EC. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem. 2005;280:34661–34666. doi: 10.1074/jbc.M504868200. PubMed DOI

ZHOU ZW, JU HX, SUN MZ, CHEN HM, FU QP, JIANG DM. Serum fetuin-a levels in obese and non-obese subjects with and without type 2 diabetes mellitus. Clin Chim Acta. 2018;476:98–102. doi: 10.1016/j.cca.2017.11.023. PubMed DOI

ZIYREK M, TAYYARECI Y, YURDAKUL S, SAHIN ST, YILDIRIMTURK O, AYTEKIN S. Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness and serum fetuin-A: An observational study. Anadolu Kardiyol Derg. 2013;13:752–758. doi: 10.5152/akd.2013.235. PubMed DOI