Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem
PubMed
19228824
DOI
10.1530/eje-08-0890
PII: EJE-08-0890
Knihovny.cz E-zdroje
- MeSH
- autoprotilátky krev MeSH
- choriogonadotropin krev fyziologie MeSH
- hormony štítné žlázy krev MeSH
- jodidperoxidasa imunologie MeSH
- komplikace těhotenství krev diagnóza MeSH
- lidé MeSH
- nemoci štítné žlázy krev diagnóza MeSH
- prediktivní hodnota testů MeSH
- první trimestr těhotenství krev fyziologie MeSH
- referenční hodnoty MeSH
- reprodukovatelnost výsledků MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- testy funkce štítné žlázy normy MeSH
- thyreotropin krev MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- autoprotilátky MeSH
- choriogonadotropin MeSH
- hormony štítné žlázy MeSH
- jodidperoxidasa MeSH
- thyreotropin MeSH
BACKGROUND: Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies' positivity. METHODS: We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH during the first trimester of pregnancy was determined using the log transformation, and then summarized as the geometrical mean (95% CI); following which, a suitable decision point for anti-TPO positivity was set. RESULTS: The reference interval for TSH was determined to be 0.06-3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. CONCLUSION: Determination of the reference interval for TSH during early pregnancy is one of the basic requirements when implementing a general examination of the thyroid gland at the beginning of pregnancy. The decision level for positivity of anti-TPO is more than double the manufacturer's reference interval.
Citace poskytuje Crossref.org
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