Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy
Language English Country Great Britain, England Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
19228824
DOI
10.1530/eje-08-0890
PII: EJE-08-0890
Knihovny.cz E-resources
- MeSH
- Autoantibodies blood MeSH
- Chorionic Gonadotropin blood physiology MeSH
- Thyroid Hormones blood MeSH
- Iodide Peroxidase immunology MeSH
- Pregnancy Complications blood diagnosis MeSH
- Humans MeSH
- Thyroid Diseases blood diagnosis MeSH
- Predictive Value of Tests MeSH
- Pregnancy Trimester, First blood physiology MeSH
- Reference Values MeSH
- Reproducibility of Results MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Thyroid Function Tests standards MeSH
- Thyrotropin blood MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Chorionic Gonadotropin MeSH
- Thyroid Hormones MeSH
- Iodide Peroxidase MeSH
- Thyrotropin MeSH
BACKGROUND: Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies' positivity. METHODS: We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH during the first trimester of pregnancy was determined using the log transformation, and then summarized as the geometrical mean (95% CI); following which, a suitable decision point for anti-TPO positivity was set. RESULTS: The reference interval for TSH was determined to be 0.06-3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. CONCLUSION: Determination of the reference interval for TSH during early pregnancy is one of the basic requirements when implementing a general examination of the thyroid gland at the beginning of pregnancy. The decision level for positivity of anti-TPO is more than double the manufacturer's reference interval.
References provided by Crossref.org
Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy
