Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29027583
DOI
10.1007/s00403-017-1785-5
PII: 10.1007/s00403-017-1785-5
Knihovny.cz E-zdroje
- Klíčová slova
- Apoptosis, Cell-free DNA, Inflammation, Nucleosomes, Psoriasis,
- MeSH
- apoptóza MeSH
- biologické markery krev MeSH
- C-reaktivní protein analýza MeSH
- dospělí MeSH
- interleukin-6 krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nukleozomy genetika metabolismus MeSH
- progrese nemoci MeSH
- psoriáza krev patologie MeSH
- senioři MeSH
- stupeň závažnosti nemoci MeSH
- TNF-alfa krev MeSH
- volné cirkulující nukleové kyseliny krev MeSH
- zánět MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- IL6 protein, human MeSH Prohlížeč
- interleukin-6 MeSH
- nukleozomy MeSH
- TNF-alfa MeSH
- volné cirkulující nukleové kyseliny MeSH
Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-α, CRP, and IL-6. The range of PASI score in psoriatic patients was 10-34 (median 19). In the patients, we found significantly elevated levels (p < 0.001) of cfDNA, nucleosomes, TNF-α, CRP, and IL-6. We did not find any significant relationship between the analyzed parameters in either group (i.e., experimental or control). Elevated levels of the biomarkers of inflammation (TNF-α, CRP, and IL-6) and the indicators of apoptosis (cfDNA, circulating nucleosomes) proved that exacerbated psoriasis vulgaris is associated with a high degree of systemic inflammatory responses and dysregulated apoptotic pathways.
Citace poskytuje Crossref.org
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Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
