Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
29027583
DOI
10.1007/s00403-017-1785-5
PII: 10.1007/s00403-017-1785-5
Knihovny.cz E-resources
- Keywords
- Apoptosis, Cell-free DNA, Inflammation, Nucleosomes, Psoriasis,
- MeSH
- Apoptosis MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis MeSH
- Adult MeSH
- Interleukin-6 blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Nucleosomes genetics metabolism MeSH
- Disease Progression MeSH
- Psoriasis blood pathology MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Tumor Necrosis Factor-alpha blood MeSH
- Cell-Free Nucleic Acids blood MeSH
- Inflammation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
- IL6 protein, human MeSH Browser
- Interleukin-6 MeSH
- Nucleosomes MeSH
- Tumor Necrosis Factor-alpha MeSH
- Cell-Free Nucleic Acids MeSH
Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-α, CRP, and IL-6. The range of PASI score in psoriatic patients was 10-34 (median 19). In the patients, we found significantly elevated levels (p < 0.001) of cfDNA, nucleosomes, TNF-α, CRP, and IL-6. We did not find any significant relationship between the analyzed parameters in either group (i.e., experimental or control). Elevated levels of the biomarkers of inflammation (TNF-α, CRP, and IL-6) and the indicators of apoptosis (cfDNA, circulating nucleosomes) proved that exacerbated psoriasis vulgaris is associated with a high degree of systemic inflammatory responses and dysregulated apoptotic pathways.
References provided by Crossref.org
Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls
Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
