The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers
Language English Country United States Media print
Document type Journal Article, Practice Guideline, Review
PubMed
34128484
DOI
10.1097/pap.0000000000000309
PII: 00125480-202107000-00002
Knihovny.cz E-resources
- MeSH
- Immunotherapy * MeSH
- Carcinoma, Transitional Cell drug therapy metabolism pathology MeSH
- Humans MeSH
- Biomarkers, Tumor metabolism MeSH
- Neoplasm Staging MeSH
- Urologic Neoplasms drug therapy metabolism pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Practice Guideline MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.
Department of Histopathology and Molecular Diagnostics University Hospital Careggi Florence Italy
Department of Pathology All India Institute of Medical Sciences New Delhi Delhi India
Department of Pathology and Laboratory Medicine Oregon Health Science University OR
Department of Pathology and Laboratory Medicine University of South Florida Gainesville FL
Department of Pathology and Laboratory Medicine University of Tennessee Health Science Memphis
Department of Pathology Hôpital Tenon Sorbonne University
Department of Pathology Koc Univiversity School of Medicine Istanbul Turkey
Department of Pathology Mayo Clinic Rochester MN
Department of Pathology MD Anderson Cancer Center Houston
Department of Pathology Medical University Vienna Vienna General Hospital
Department of Pathology Montreal QC
Department of Pathology Taipei Veterans General Hospital Tapeh Taiwan
Department of Pathology The University of Alabama at Birmingham Birmingham AL
Department of Pathology Tufts Medical Center Boston MA
Department of Pathology University of Chicago Chicago IL
Department of Pathology University of Erlangen Nuremberg Erlangen Germany
Department of Pathology University of Michigan Medical School Ann Arbor MI
Department of Pathology University of Washington School of Medicine Seattle Washington DC
Department of Urology APHP Sorbonne University Paris France
Department of Urology Comprehensive Cancer Center Medical University Vienna Vienna Austria
Department of Urology University of Southern California Keck School of Medicine Los Angeles CA
Departments of Pathology Microbiology and Immunology
Oncology Memorial Sloan Kettering Cancer Center New York NY
Oncology The Johns Hopkins Medical Institutions Baltimore MD
Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic Cleveland OH
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