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The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers

. 2021 Jul 01 ; 28 (4) : 196-208.

Language English Country United States Media print

Document type Journal Article, Practice Guideline, Review

Links

PubMed 34128484
DOI 10.1097/pap.0000000000000309
PII: 00125480-202107000-00002
Knihovny.cz E-resources

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.

Department of Histopathology and Molecular Diagnostics University Hospital Careggi Florence Italy

Department of Pathology All India Institute of Medical Sciences New Delhi Delhi India

Department of Pathology and Laboratory Medicine Cumming School of Medicine University of Calgary Calgary AB Canada

Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN

Department of Pathology and Laboratory Medicine Oregon Health Science University OR

Department of Pathology and Laboratory Medicine University of South Florida Gainesville FL

Department of Pathology and Laboratory Medicine University of Tennessee Health Science Memphis

Department of Pathology Charles University Prague Faculty of Medicine and University Hospital in Plzen Plzen Czech Republic

Department of Pathology Hôpital Tenon Sorbonne University

Department of Pathology Koc Univiversity School of Medicine Istanbul Turkey

Department of Pathology Mayo Clinic Rochester MN

Department of Pathology MD Anderson Cancer Center Houston

Department of Pathology Medical University Vienna Vienna General Hospital

Department of Pathology Montreal QC

Department of Pathology Taipei Veterans General Hospital Tapeh Taiwan

Department of Pathology The University of Alabama at Birmingham Birmingham AL

Department of Pathology Tufts Medical Center Boston MA

Department of Pathology University of Chicago Chicago IL

Department of Pathology University of Erlangen Nuremberg Erlangen Germany

Department of Pathology University of Michigan Medical School Ann Arbor MI

Department of Pathology University of Washington School of Medicine Seattle Washington DC

Department of Pathology West German Cancer Center University Hospital Essen University of Duisburg Essen Duisburg

Department of Urology APHP Sorbonne University Paris France

Department of Urology Comprehensive Cancer Center Medical University Vienna Vienna Austria

Department of Urology University of Southern California Keck School of Medicine Los Angeles CA

Departments of Pathology

Departments of Pathology Microbiology and Immunology

Medical Oncology

Oncology Memorial Sloan Kettering Cancer Center New York NY

Oncology The Johns Hopkins Medical Institutions Baltimore MD

Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic Cleveland OH

Urology

Urology Emory University School of Medicine Atlanta GA

Urology Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX

Urology Vanderbilt University Medical Center Nashville TN

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