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Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Ashrafizadeh, Milad
Author Ashrafizadeh, Milad Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956, Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey
Mirzaei, Sepideh
Author Mirzaei, Sepideh Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
Gholami, Mohammad Hossein
Author Gholami, Mohammad Hossein Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Hashemi, Farid
Author Hashemi, Farid Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Zabolian, Amirhossein
Author Zabolian, Amirhossein Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Raei, Mehdi
Author Raei, Mehdi Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hushmandi, Kiavash
Author Hushmandi, Kiavash Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Zarrabi, Ali
Author Zarrabi, Ali Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey
Voelcker, Nicolas H
Author Voelcker, Nicolas H Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, Victoria, 3168, Australia; Melbourne Centre for Nanofabrication, Victorian Node of the Australian National Fabrication Facility, 151 Wellington Road, Clayton, Victoria 3168, Australia
Aref, Amir Reza
Author Aref, Amir Reza Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Translational Sciences, Xsphera Biosciences Inc., Boston, MA, USA
Hamblin, Michael R
Author Hamblin, Michael R Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa; Radiobiology Research Center, Iran University of Medical Science, Tehran, Iran
Varma, Rajender S
Author Varma, Rajender S Regional Center of Advanced Technologies and Materials, Palacky University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic
Samarghandian, Saeed
Author Samarghandian, Saeed Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
Arostegi, I J
Author Arostegi, I J NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain
Alzola, M
Author Alzola, M NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain
Kumar, Alan Prem
Author Kumar, Alan Prem NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Cancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore
Thakur, Vijay Kumar
Author Thakur, Vijay Kumar Biorefining and Advanced Materials Research Center, Scotland's Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UK; Department of Mechanical Engineering, School of Engineering, Shiv Nadar University, Uttar Pradesh 201314, India
Nabavi, Noushin
Author Nabavi, Noushin Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H3Z6, Canada
Makvandi, Pooyan
Author Makvandi, Pooyan Istituto Italiano di Tecnologia, Center for Materials Interfaces, viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy. Electronic address: Pooyan.makvandi@iit.it
Tay, Franklin R
Author Tay, Franklin R The Graduate School, Augusta University, Augusta, GA, USA. Electronic address: ftay@augusta.edu
Orive, Gorka
Author Orive, Gorka NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain; University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria-Gasteiz, Spain; Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain; Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore. Electronic address: gorka.orive@ehu.eus

Carbohydrate polymers. 2021 Nov 15 ; 272 () : 118491. [epub] 20210727

Carbohydr Polym
ISSN 1879-1344 | 0144-8617
Source

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Review

Persistent link https://www.medvik.cz/link/pmid34420747

PubMed 34420747
DOI 10.1016/j.carbpol.2021.118491
PII: S0144-8617(21)00878-X
Knihovny.cz E-resources

Keywords
CD44, Doxorubicin, Drug resistance, Endocytosis, Hyaluronic acid, Nanodelivery system, Theranostic,
MeSH
Drug Resistance, Neoplasm * drug effects MeSH
Doxorubicin * pharmacology chemistry administration & dosage MeSH
Hyaluronic Acid * chemistry MeSH
Drug Delivery Systems methods MeSH
Humans MeSH
Neoplasms * drug therapy MeSH
Nanoparticles chemistry MeSH
Drug Carriers * chemistry MeSH
Animals MeSH
Check Tag
Humans MeSH
Animals MeSH
Publication type
Journal Article MeSH
Review MeSH
Names of Substances
Doxorubicin * MeSH
Hyaluronic Acid * MeSH
Drug Carriers * MeSH

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

Belfer Center for Applied Cancer Science Dana Farber Cancer Institute Harvard Medical School Boston MA USA; Department of Translational Sciences Xsphera Biosciences Inc Boston MA USA

Biorefining and Advanced Materials Research Center Scotland's Rural College Kings Buildings Edinburgh EH9 3JG UK; Department of Mechanical Engineering School of Engineering Shiv Nadar University Uttar Pradesh 201314 India

Department of Biology Faculty of Science Islamic Azad University Science and Research Branch Tehran Iran

Department of Comparative Biosciences Faculty of Veterinary Medicine University of Tehran Tehran Iran

Department of Food Hygiene and Quality Control Division of Epidemiology Faculty of Veterinary Medicine University of Tehran Tehran Iran

Department of Urological Sciences and Vancouver Prostate Centre University of British Columbia Vancouver BC V6H3Z6 Canada

Faculty of Engineering and Natural Sciences Sabanci University Orta Mahalle Üniversite Caddesi No 27 Orhanlı Tuzla 34956 Istanbul Turkey; Sabanci University Nanotechnology Research and Application Center Tuzla 34956 Istanbul Turkey

Faculty of Veterinary Medicine Kazerun Branch Islamic Azad University Kazerun Iran

Health Research Center Life Style Institute Baqiyatallah University of Medical Sciences Tehran Iran

Istituto Italiano di Tecnologia Center for Materials Interfaces viale Rinaldo Piaggio 34 56025 Pontedera Pisa Italy

Laser Research Centre Faculty of Health Science University of Johannesburg Doornfontein 2028 South Africa; Radiobiology Research Center Iran University of Medical Science Tehran Iran

Monash Institute of Pharmaceutical Sciences Parkville Victoria 3052 Australia; Commonwealth Scientific and Industrial Research Organisation Clayton Victoria 3168 Australia; Melbourne Centre for Nanofabrication Victorian Node of the Australian National Fabrication Facility 151 Wellington Road Clayton Victoria 3168 Australia