Polymeric nanocomposites have been outstanding functional materials and have garnered immense attention as sustainable materials to address multi-disciplinary problems. MXenes have emerged as a newer class of 2D materials that produce metallic conductivity upon interaction with hydrophilic species, and their delamination affords monolayer nanoplatelets of a thickness of about one nm and a side size in the micrometer range. Delaminated MXene has a high aspect ratio, making it an alluring nanofiller for multifunctional polymer nanocomposites. Herein, we have classified and discussed the structure, properties and application of major polysaccharide-based electroactive hydrogels (hyaluronic acid (HA), alginate sodium (SA), chitosan (CS) and cellulose) in biomedical applications, starting with the brief historical account of MXene's development followed by successive discussions on the synthesis methods, structures and properties of nanocomposites encompassing polysaccharides and MXenes, including their biomedical applications, cytotoxicity and biocompatibility aspects. Finally, the MXenes and their utility in the biomedical arena is deliberated with an eye on potential opportunities and challenges anticipated for them in the future, thus promoting their multifaceted applications.

Biology Department College of Science Jouf University Sakaka 72388 Saudi Arabia

Department of Biology Faculty of Science University College of Taymaa University of Tabuk Tabuk 71491 Saudi Arabia

Department of Chemistry College of Science King Khalid University Abha 61413 Saudi Arabia

Department of Clinical Pharmacy Girls Section Prince Sattam Bin Abdul Aziz University Alkharj Alkharj 11942 Saudi Arabia

Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju 26426 Gangwon Korea

Department of Pharmaceutical Sciences and Technology Institute of Chemical Technology Mumbai 400019 India

Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College Jeddah 21442 Saudi Arabia

Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Ain Shams University Cairo 11566 Egypt

Department of Pharmacology and Toxicology Faculty of Pharmacy King Abdulaziz University Jeddah 21589 Saudi Arabia

Labortory of Biomolecules and Organic Synthesis Department of Chemistry Faculty of Sciences Ben M'Sick University Hassan 2 of Casablanca Casablanca 20000 Morocco

Pharmacology Department Faculty of Veterinary Medicine Suez Canal University Ismailia 41522 Egypt

Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palacky University Šlechtitelů 27 783 71 Olomouc Czech Republic

Regional Drug Information Center Ministry of Health Jeddah 21589 Saudi Arabia

Zoology Department Faculty of Science Cairo University Giza 12613 Egypt

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