Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
34437383
PubMed Central
PMC8402572
DOI
10.3390/toxins13080512
PII: toxins13080512
Knihovny.cz E-zdroje
- Klíčová slova
- anorexia, deoxynivalenol, intestinal hormones, mycotoxin, trichothecene,
- MeSH
- benzamidy terapeutické užití MeSH
- gastrointestinální hormony krev MeSH
- myši MeSH
- nechutenství chemicky indukované farmakoterapie metabolismus MeSH
- peptidové fragmenty terapeutické užití MeSH
- piperaziny terapeutické užití MeSH
- přijímání potravy účinky léků MeSH
- proglumid terapeutické užití MeSH
- receptory gastrointestinálních hormonů antagonisté a inhibitory MeSH
- stravovací zvyklosti účinky léků MeSH
- trichotheceny toxicita MeSH
- žaludeční inhibiční polypeptid terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- benzamidy MeSH
- deoxynivalenol MeSH Prohlížeč
- exendin (9-39) MeSH Prohlížeč
- gastric inhibitory polypeptide (3-30)-amide MeSH Prohlížeč
- gastrointestinální hormony MeSH
- JNJ-31020028 MeSH Prohlížeč
- peptidové fragmenty MeSH
- piperaziny MeSH
- proglumid MeSH
- receptory gastrointestinálních hormonů MeSH
- trichotheceny MeSH
- žaludeční inhibiční polypeptid MeSH
Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the "modeling of acute antifeeding in mice" as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH2 attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON.
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