Cardiorespiratory fitness (CRF) is a strong independent predictor of morbidity and mortality. However, there is no recent information about the impact of CRF on cardiometabolic risk specifically in Central and Eastern Europe, which are characterized by different biological and social determinants of health. In this cross-sectional study normative CRF values were proposed and the association between CRF and cardiometabolic outcomes was evaluated in an adult Czechian population. In 2054 participants (54.6% females), median age 48 (IQR 19 years), the CRF was predicted from a non-exercise equation. Multivariable-adjusted logistic regressions were carried out to determine the associations. Higher CRF quartiles were associated with lower prevalence of hypertension, type 2 diabetes (T2D) and dyslipidemia. Comparing subjects within the lowest CRF, we see that those within the highest CRF had decreased chances of hypertension (odds ratio (OR) = 0.36; 95% CI: 0.22-0.60); T2D (OR = 0.16; 0.05-0.47), low HDL-c (OR = 0.32; 0.17-0.60), high low-density lipoprotein (OR = 0.33; 0.21-0.53), high triglycerides (OR = 0.13; 0.07-0.81), and high cholesterol (OR = 0.44; 0.29-0.69). There was an inverse association between CRF and cardiometabolic outcomes, supporting the adoption of a non-exercise method to estimate CRF of the Czech population. Therefore, more accurate cardiometabolic studies can be performed incorporating the valuable CRF metric.

Department of Global Health and Population Harvard TH Chan School of Public Health Harvard University Boston MA 02115 USA

Department of Physical Education School of Education University of Los Andes Mérida 5101 Venezuela

Department of Public Health Faculty of Medicine Masaryk University 656 91 Brno Czech Republic

Division of Endocrinology Diabetes and Bone Disease Icahn School of Medicine at Mount Sinai New York NY 10029 USA

EDU Medicine and Health Digital Education Holdings Ltd KKR 1320 Kalkara Malta

Foundation for Clinic Public Health and Epidemiology Research of Venezuela Caracas 1060 Venezuela

International Clinical Research Center 656 92 Brno Czech Republic

LifeDoc Health Memphis TN 38119 USA

Research Centre for Toxic Compounds in the Environment Masaryk University 656 91 Brno Czech Republic

The Marie Josée and Henry R Kravis Center for Cardiovascular Health at Mount Sinai Heart Icahn School of Medicine at Mount Sinai New York NY 10029 USA

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