Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
NV18-03-00277
Ministerstvo Zdravotnictví Ceské Republiky
PubMed
34682758
PubMed Central
PMC8537017
DOI
10.3390/jcm10204636
PII: jcm10204636
Knihovny.cz E-zdroje
- Klíčová slova
- MICA, MICB, NK cells, NKG2D, allogeneic hematopoietic cell transplantation, graft-versus-host disease, graft-versus-tumor effect,
- Publikační typ
- časopisecké články MeSH
NKG2D and its ligands, MICA and MICB, are known as the key regulators of NK cells. NK cells are the first reconstituted cells after the allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT outcome. In the presented study, we investigated the single amino acid changes across the exons 2-4 of MICA and MICB genes, and point mutations within the NKG2D gene, which defines the type of NKG2D haploblock (HNK/LNK) in the donors (n = 124), as well as in patients with acute myeloid leukemia (n = 78). In our cohort, we found that graft from a donor with at least one MICA allele containing glycine at position 14 (MICA-14Gly) is significantly associated with deterioration of a patient's overall survival (OS) (p < 0.05). We also observed a negative effect of MICB-58 (Lys → Glu) polymorphism on relapse-free survival (RFS), although it was not statistically significant in multivariate analysis (p = 0.069). To our knowledge, this is the first work describing the role of MICA-14 and MICB-58 polymorphisms on HSCT outcome.
Department of Haematology and Oncology University Hospital Pilsen 304 60 Pilsen Czech Republic
NTIS Faculty of Applied Sciences University of West Bohemia 301 00 Pilsen Czech Republic
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