A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in CSF2 (rs25881), FLT1 (rs722503), TFPI (C-399T) and TLR9 (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for CSF2 and FLT1 polymorphisms, CC variants for TLR9 and TFPI SNPs, TTC for CSF2, FLT1 and TLR9 polymorphisms, TTT for FLT1, TLR9 and TFPI SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the CSF2, FLT1 and TLR9 SNPs and the CCTC for the CSF2, FLT1, TLR9 and TFPI polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.

Biomedical Research Center University Hospital Hradec Kralove 500 03 Hradec Kralove Czech Republic

Department of Gynecology and Obstetrics Medical University of Lodz 281 289 Rzgowska St 93 338 Lodz Poland

Department of Obstetrics and Gynecology Polish Mother's Memorial Hospital Research Institute 93 338 Lodz Poland

Department of Obstetrics and Gynecology University Hospital Hradec Kralove Faculty of Medicine in Hradec Kralove Charles University Simkova 870 500 03 Hradec Kralove Czech Republic

Department of Perinatology Obstetrics and Gynecology Polish Mother's Memorial Hospital Research Institute 93 338 Lodz Poland

Laboratory of Prenatal Fetal and Maternal Diagnostics Polish Mother's Memorial Hospital Research Institute 93 338 Lodz Poland

Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening Polish Mother's Memorial Hospital Research Institute 281 289 Rzgowska St 93 338 Lodz Poland

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